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    IGF1 insulin like growth factor 1 [ Sus scrofa (pig) ]

    Gene ID: 397491, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IGF1provided by VGNC
    Official Full Name
    insulin like growth factor 1provided by VGNC
    Primary source
    VGNC:VGNC:98044
    See related
    Ensembl:ENSSSCG00000000857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    IGF-1; IGF-I; Npt2B
    Expression
    Broad expression in subcutaneous adipose (RPKM 8.1), ovary (RPKM 2.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See IGF1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (81762027..81909253)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 5 NC_010447.4 (85700439..85773714)

    Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene phenylalanine hydroxylase Neighboring gene uncharacterized LOC106510404 Neighboring gene uncharacterized LOC110260785 Neighboring gene uncharacterized LOC110260784 Neighboring gene PARP1 binding protein Neighboring gene pro-melanin concentrating hormone Neighboring gene nucleoporin 37

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Sorbic acid improves growth performance and regulates insulin-like growth factor system gene expression in swine. Luo ZF, et al. J Anim Sci, 2011 Aug. PMID 21421836
    2. Nucleotide sequence of porcine insulin-like growth factor. 1:5' untranslated region, exons 1 and 2 and mRNA. Müller M, et al. Nucleic Acids Res, 1990 Jan 25. PMID 2326169, Free PMC Article
    3. Porcine insulin-like growth factor-I (pIGF-I): complementary deoxyribonucleic acid cloning and uterine expression of messenger ribonucleic acid encoding evolutionarily conserved IGF-I peptides. Tavakkol A, et al. Mol Endocrinol, 1988 Aug. PMID 3211153
    4. Assignment of the gene for porcine insulin-like growth factor 1 (IGF1) to chromosome 5 by linkage mapping. Winterø AK, et al. Anim Genet, 1994 Feb. PMID 8161019
    5. The porcine insulin-like growth factor-I gene: characterization and expression of alternate transcription sites. Weller PA, et al. J Mol Endocrinol, 1993 Oct. PMID 8297476

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRISPR/Cas9-Mediated Specific Integration of Fat-1 and IGF-1 at the pRosa26 Locus.
      Title: CRISPR/Cas9-Mediated Specific Integration of Fat-1 and IGF-1 at the pRosa26 Locus.
    2. A SNP in the 3'UTR of the porcine IGF-1 gene interacts with miR-new14 to affect IGF-1 expression, proliferation and apoptosis of PK-15 cells.
      Title: A SNP in the 3'UTR of the porcine IGF-1 gene interacts with miR-new14 to affect IGF-1 expression, proliferation and apoptosis of PK-15 cells.
    3. Role of Akt and mammalian target of rapamycin signalling in insulin-like growth factor 1-mediated cell proliferation in porcine Sertoli cells.
      Title: Role of Akt and mammalian target of rapamycin signalling in insulin-like growth factor 1-mediated cell proliferation in porcine Sertoli cells.
    4. This finding confirmed that miR-511 inhibits proliferation and promotes apoptosis by downregulating the IGF-1 in PK-15 cells.
      Title: A miR-511-binding site SNP in the 3'UTR of IGF-1 gene is associated with proliferation and apoptosis of PK-15 cells.
    5. High temperature, independent feed intake reduction, increases IGF-1:IGFBP-3 ratio.
      Title: Chronic heat stress increases insulin-like growth factor-1(IGF-1) but does not affect IGF-binding proteins in growing pigs.
    6. the dipeptide Pro-Asp promoted IGF-1 secretion and expression in hepatocytes.
      Title: The dipeptide Pro-Asp promotes IGF-1 secretion and expression in hepatocytes by enhancing JAK2/STAT5 signaling pathway.
    7. The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.
      Title: Dietary protein-induced hepatic IGF-1 secretion mediated by PPARγ activation.
    8. Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
      Title: Interrelationships between ovarian follicles grown in culture and possible mediators.
    9. This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.
      Title: Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.
    10. Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
      Title: Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-like growth factor I
    Names
    somatomedin C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214256.1 → NP_999421.1  insulin-like growth factor I precursor

      See identical proteins and their annotated locations for NP_999421.1

      Status: VALIDATED

      Source sequence(s)
      M31175
      UniProtKB/TrEMBL
      Q0PPT2
      Conserved Domains (1) summary
      cd04368
      Location:26 → 93
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

      Range
      81762027..81909253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021091138.1 → XP_020946797.1  insulin-like growth factor I isoform X3

      UniProtKB/TrEMBL
      A0A4X1T598
      Conserved Domains (1) summary
      cd04368
      Location:26 → 93
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

    2. XM_005664197.3 → XP_005664254.1  insulin-like growth factor I isoform X4

      See identical proteins and their annotated locations for XP_005664254.1

      UniProtKB/TrEMBL
      A0A2C9F3F9, A0A4X1T5R2, A0A8D0UYR0, G9BFS5
      Related
      ENSSSCP00000030873.3, ENSSSCT00000035604.4
      Conserved Domains (1) summary
      cd04368
      Location:49 → 116
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

    3. XM_005664195.3 → XP_005664252.1  insulin-like growth factor I isoform X1

      See identical proteins and their annotated locations for XP_005664252.1

      UniProtKB/TrEMBL
      A0A287AC25, A0A288CFX8, A0A4X1T3B8, A0A8D0NN75, A0A8D1ETG0
      Related
      ENSSSCP00000041355.3, ENSSSCT00000050807.3
      Conserved Domains (1) summary
      cd04368
      Location:49 → 116
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

    4. XM_005664198.3 → XP_005664255.1  insulin-like growth factor I isoform X5

      See identical proteins and their annotated locations for XP_005664255.1

      UniProtKB/Swiss-Prot
      P16545
      UniProtKB/TrEMBL
      Q0PPT3, Q45QB4
      Related
      ENSSSCP00000000916.4, ENSSSCT00000000936.5
      Conserved Domains (1) summary
      cd04368
      Location:49 → 116
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

    5. XM_021091140.1 → XP_020946799.1  insulin-like growth factor I isoform X6

      UniProtKB/TrEMBL
      A0A8D1C5Z8, A0A8D1TX06, G9BFS6
      Conserved Domains (1) summary
      cd04368
      Location:49 → 116
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

    6. XM_005664196.3 → XP_005664253.1  insulin-like growth factor I isoform X2

      UniProtKB/TrEMBL
      A0A4X1T4H1, A0A4X1T598, A0A8D0KJC7, I3LBI3
      Related
      ENSSSCP00000021404.1, ENSSSCT00000023468.3
      Conserved Domains (1) summary
      cd04368
      Location:33 → 100
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

    7. XM_005664199.3 → XP_005664256.1  insulin-like growth factor I isoform X7

      See identical proteins and their annotated locations for XP_005664256.1

      UniProtKB/TrEMBL
      G9BFS9, Q0PPT2
      Conserved Domains (1) summary
      cd04368
      Location:33 → 100
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16545.1 GenPept UniProtKB/Swiss-Prot:P16545

    Gene LinkOut

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