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    pst-1 Adenosine 3'-phospho 5'-phosphosulfate transporter 1 [ Caenorhabditis elegans ]

    Gene ID: 178980, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pst-1
    Official Full Name
    Adenosine 3'-phospho 5'-phosphosulfate transporter 1
    Primary source
    WormBase:WBGene00004206
    Locus tag
    CELE_M03F8.2
    See related
    AllianceGenome:WB:WBGene00004206
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate transport. Located in Golgi cisterna membrane. Is expressed in AMshL; AMshR; pharyngeal gland cell; and seam cell. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 26. Orthologous to human SLC35B2 (solute carrier family 35 member B2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pst-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (5943467..5951417)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene TPR_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Neur_chan_LBD domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two Golgi-resident 3'-Phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans. Dejima K, et al. J Biol Chem, 2010 Aug 6. PMID 20529843, Free PMC Article
    2. The PAPS transporter PST-1 is required for heparan sulfation and is essential for viability and neural development in C. elegans. Bhattacharya R, et al. J Cell Sci, 2009 Dec 15. PMID 19920077, Free PMC Article
    3. Most ultraviolet irradiation induced mutations in the nematode Caenorhabditis elegans are chromosomal rearrangements. Stewart HI, et al. Mutat Res, 1991 Jul. PMID 2067542
    4. Genetic analysis of a major segment [LGV(left)] of the genome of Caenorhabditis elegans. Johnsen RC, et al. Genetics, 1991 Nov. PMID 1752418, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. pst-1 and pst-2 play different physiological roles in heparan sulfate modification and development
      Title: Two Golgi-resident 3'-Phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans.
    2. pst-1 is required for cell viability and nervous system development.
      Title: The PAPS transporter PST-1 is required for heparan sulfation and is essential for viability and neural development in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-phospho-5'-adenylyl sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Adenosine 3'-phospho 5'-phosphosulfate transporter 1
    NP_001024060.1
    • Confirmed by transcript evidence
    NP_001360551.1
    • Confirmed by transcript evidence
    NP_001380252.1
    • Confirmed by transcript evidence
    NP_741545.2
    • Confirmed by transcript evidence
    NP_741546.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5943467..5951417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373028.2 → NP_001360551.1  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WUZ8
      Conserved Domains (1) summary
      pfam08449
      Location:106 → 376
      UAA; UAA transporter family

    2. NM_171463.5 → NP_741545.2  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741545.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16377, Q59DN2, Q59DN3, Q59DN4, Q8MXJ9
      Conserved Domains (2) summary
      pfam08449
      Location:106 → 408
      UAA; UAA transporter family
      cl23754
      Location:297 → 408
      EamA; EamA-like transporter family

    3. NM_171464.6 → NP_741546.3  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741546.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MXJ9
      Conserved Domains (2) summary
      pfam08449
      Location:121 → 423
      UAA; UAA transporter family
      cl23754
      Location:312 → 423
      EamA; EamA-like transporter family

    4. NM_001028889.4 → NP_001024060.1  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024060.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MXJ9
      Conserved Domains (1) summary
      pfam08449
      Location:121 → 391
      UAA; UAA transporter family

    5. NM_001392522.1 → NP_001380252.1  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WVL2
      Conserved Domains (1) summary
      pfam08449
      Location:1 → 106
      UAA; UAA transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MXJ9.4

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