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    fut-3 Alpha-(1,3)-fucosyltransferase fut-3 [ Caenorhabditis elegans ]

    Gene ID: 173958, updated on 2-Nov-2024

    Summary

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    Official Symbol
    fut-3
    Official Full Name
    Alpha-(1,3)-fucosyltransferase fut-3
    Primary source
    WormBase:WBGene00006402
    Locus tag
    CELE_F59E12.13
    See related
    AllianceGenome:WB:WBGene00006402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. Involved in fucosylation. Predicted to be located in Golgi cisterna membrane. Orthologous to human FUT5 (fucosyltransferase 5) and FUT6 (fucosyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See fut-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (5657709..5659775, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative serine/threonine-protein kinase zyg-1 Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Bromo domain-containing protein Neighboring gene Intraflagellar transport protein 43 homolog Neighboring gene TFIIS N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family. Nguyen K, et al. Glycobiology, 2007 Jun. PMID 17369288
    2. Molecular basis of anti-horseradish peroxidase staining in Caenorhabditis elegans. Paschinger K, et al. J Biol Chem, 2004 Nov 26. PMID 15364955
    3. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT enables alpha-(1->3)-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fucosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fucosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Alpha-(1,3)-fucosyltransferase fut-3
    NP_495106.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5657709..5659775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062705.11 → NP_495106.1  Alpha-(1,3)-fucosyltransferase fut-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495106.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFP5
      Conserved Domains (2) summary
      pfam00852
      Location:204 → 378
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:64 → 168
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EFP5.1

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