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    PPARD peroxisome proliferator activated receptor delta [ Canis lupus familiaris (dog) ]

    Gene ID: 481756, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PPARDprovided by VGNC
    Official Full Name
    peroxisome proliferator activated receptor deltaprovided by VGNC
    Primary source
    VGNC:VGNC:44835
    See related
    Ensembl:ENSCAFG00845028955
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    PPAR-beta; PPAR-delta
    Orthologs
    human mouse all
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    Genomic context

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    See PPARD in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (4830969..4918771)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (4582161..4595131)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (4744188..4757152)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (4565298..4578271)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (4643973..4656940)

    Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 76 Neighboring gene DEF6 guanine nucleotide exchange factor Neighboring gene FA complementation group E Neighboring gene ribosomal protein L10a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression and investigation for polymorphisms of canine peroxisome proliferator-activated receptors. Nishii N, et al. Comp Biochem Physiol B Biochem Mol Biol, 2007 Aug. PMID 17512769
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of PPARbeta showed only small variations during canine adipocyte differentiation.
      Title: Cloning, expression and investigation for polymorphisms of canine peroxisome proliferator-activated receptors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxisome proliferator-activated receptor delta
    Names
    nuclear receptor subfamily 1 group C member 2
    peroxisome proliferative activated receptor, delta
    peroxisome proliferator-activated receptor beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048102.1 → NP_001041567.1  peroxisome proliferator-activated receptor delta

      See identical proteins and their annotated locations for NP_001041567.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ648277
      UniProtKB/Swiss-Prot
      Q0ZAQ8
      UniProtKB/TrEMBL
      A0A8C0K2K4, A0A8C0NFH2, A0A8I3PZ92
      Conserved Domains (2) summary
      cd06932
      Location:173 → 440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73 → 156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051816.1 Reference ROS_Cfam_1.0

      Range
      4830969..4918771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038682756.1 → XP_038538684.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      Q0ZAQ8
      UniProtKB/TrEMBL
      A0A8C0K2K4, A0A8C0NFH2, A0A8I3PZ92
      Related
      ENSCAFP00845040209.1, ENSCAFT00845051265.1
      Conserved Domains (2) summary
      cd06932
      Location:173 → 440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73 → 156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    2. XM_038682760.1 → XP_038538688.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      Q0ZAQ8
      UniProtKB/TrEMBL
      A0A8C0K2K4, A0A8C0NFH2, A0A8I3PZ92
      Conserved Domains (2) summary
      cd06932
      Location:173 → 440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73 → 156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    3. XM_038682757.1 → XP_038538685.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      Q0ZAQ8
      UniProtKB/TrEMBL
      A0A8C0K2K4, A0A8C0NFH2, A0A8I3PZ92
      Conserved Domains (2) summary
      cd06932
      Location:173 → 440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73 → 156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    4. XM_038682759.1 → XP_038538687.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      Q0ZAQ8
      UniProtKB/TrEMBL
      A0A8C0K2K4, A0A8C0NFH2, A0A8I3PZ92
      Conserved Domains (2) summary
      cd06932
      Location:173 → 440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73 → 156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    5. XM_038682758.1 → XP_038538686.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      Q0ZAQ8
      UniProtKB/TrEMBL
      A0A8C0K2K4, A0A8C0NFH2, A0A8I3PZ92
      Conserved Domains (2) summary
      cd06932
      Location:173 → 440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73 → 156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049272.1 Alternate UMICH_Zoey_3.1

      Range
      4565298..4578271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

      Range
      4643973..4656940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

      Range
      4744188..4757152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      4582161..4595131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0ZAQ8.1 GenPept UniProtKB/Swiss-Prot:Q0ZAQ8

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