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    BOLA-DYA major histocompatibility complex, class II, DY alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 282497, updated on 4-Oct-2024

    Summary

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    Gene symbol
    BOLA-DYA
    Gene description
    major histocompatibility complex, class II, DY alpha
    See related
    BGD:BT11780; Ensembl:ENSBTAG00000002581
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    DYA; BoLA-DQA
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    Genomic context

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    See BOLA-DYA in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (7072088..7077975)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene glutamate-cysteine ligase catalytic subunit Neighboring gene MHC class II antigen DS beta Neighboring gene major histocompatibility complex, class II, DY beta Neighboring gene major histocompatibility complex, class II, DO beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DY genes of the cattle MHC: expression and comparative analysis of an unusual class II MHC gene pair. Ballingall KT, et al. Immunogenetics, 2004 Feb. PMID 14745522
    2. The nucleotide sequence of the bovine MHC class II alpha genes: DRA, DOA, and DYA. van der Poel JJ, et al. Immunogenetics, 1990. PMID 2298463
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    major histocompatibility complex, class II, DY alpha
    Names
    MHC class II antigen
    putative MHC class II antigen, alpha chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012678.1 → NP_001012696.1  major histocompatibility complex, class II, DY alpha precursor

      See identical proteins and their annotated locations for NP_001012696.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ580583
      UniProtKB/TrEMBL
      Q32S36, Q70IB6
      Related
      ENSBTAP00000003342.3, ENSBTAT00000003342.5
      Conserved Domains (3) summary
      cd05767
      Location:110 → 203
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      smart00920
      Location:29 → 108
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      pfam16196
      Location:201 → 252
      C1-set_C; C1-set C-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      7072088..7077975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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