U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Pigk phosphatidylinositol glycan anchor biosynthesis, class K [ Mus musculus (house mouse) ]

    Gene ID: 329777, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pigkprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Kprovided by MGI
    Primary source
    MGI:MGI:1913863
    See related
    Ensembl:ENSMUSG00000039047 AllianceGenome:MGI:1913863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIG-K; Gm38470; 3000001O05Rik
    Summary
    Predicted to enable GPI-anchor transamidase activity. Predicted to be involved in attachment of GPI anchor to protein. Predicted to be part of GPI-anchor transamidase complex. Is expressed in several structures, including alimentary system; eye; heart; integumental system; and nervous system. Orthologous to human PIGK (phosphatidylinositol glycan anchor biosynthesis class K). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.3), frontal lobe adult (RPKM 3.5) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pigk in Genome Data Viewer
    Location:
    3; 3 H3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (152419718..152548705)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152714085..152842926)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene adenylate kinase 5 Neighboring gene expressed sequence AI115009 Neighboring gene STARR-seq mESC enhancer starr_09298 Neighboring gene STARR-positive B cell enhancer ABC_E9232 Neighboring gene predicted gene, 32085 Neighboring gene STARR-positive B cell enhancer ABC_E6147 Neighboring gene predicted gene, 40181 Neighboring gene ribosomal protein L29, pseudogene 1 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Neighboring gene STARR-positive B cell enhancer ABC_E3479 Neighboring gene predicted gene, 46830 Neighboring gene STARR-seq mESC enhancer starr_09299 Neighboring gene predicted gene, 40182

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Glycosylphosphatidylinositols in malaria pathogenesis and immunity: potential for therapeutic inhibition and vaccination. Boutlis CS, et al. Curr Top Microbiol Immunol, 2005. PMID 16265905
    2. Loss of PIGK function causes severe infantile encephalopathy and extensive neuronal apoptosis. Chen X, et al. Hum Genet, 2021 May. PMID 33392778
    3. The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase. Yu J, et al. Proc Natl Acad Sci U S A, 1997 Nov 11. PMID 9356492, Free PMC Article
    4. Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins. Eisenhaber B, et al. Bioessays, 2003 Apr. PMID 12655644
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The protein encoded by the human ortholog catalyzes the final step in glycosylphosphatidylinositol (GPI) anchoring of cell surface proteins, the transamidation reaction.
      Title: The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GPI-anchor transamidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GPI-anchor transamidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GPI-anchor transamidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of GPI anchor to protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of GPI-anchor transamidase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    GPI-anchor transamidase
    Names
    GPI transamidase
    phosphatidylinositol-glycan biosynthesis class K protein
    NP_079938.1
    NP_821135.1
    XP_006501675.1
    XP_036019035.1
    XP_036019036.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025662.5 → NP_079938.1  GPI-anchor transamidase isoform 1 precursor

      See identical proteins and their annotated locations for NP_079938.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 1) is shorter but has the same N- and C-termini compared to isoform 2.
      Source sequence(s)
      AK077893, BC060175
      Consensus CDS
      CCDS17919.1
      UniProtKB/Swiss-Prot
      Q8BH63, Q9CXY9
      UniProtKB/TrEMBL
      E9Q421
      Related
      ENSMUSP00000123772.2, ENSMUST00000159899.8
      Conserved Domains (1) summary
      cl00042
      Location:42 → 332
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    2. NM_178016.3 → NP_821135.1  GPI-anchor transamidase isoform 2 precursor

      See identical proteins and their annotated locations for NP_821135.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AK046246, AK077893, BC060175
      Consensus CDS
      CCDS17920.1
      UniProtKB/TrEMBL
      E9Q421, Q8BL63
      Related
      ENSMUSP00000045351.9, ENSMUST00000045029.15
      Conserved Domains (1) summary
      cl00042
      Location:42 → 379
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      152419718..152548705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163142.1 → XP_036019035.1  GPI-anchor transamidase isoform X1

      UniProtKB/TrEMBL
      E9Q421, Q8BXX3
      Related
      ENSMUSP00000123899.2, ENSMUST00000162642.8
      Conserved Domains (1) summary
      cl00042
      Location:42 → 332
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    2. XM_036163143.1 → XP_036019036.1  GPI-anchor transamidase isoform X2

      UniProtKB/TrEMBL
      E9Q421
      Related
      ENSMUSP00000123753.2, ENSMUST00000161596.6
      Conserved Domains (1) summary
      cl00042
      Location:42 → 332
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    3. XM_006501612.5 → XP_006501675.1  GPI-anchor transamidase isoform X3

      Conserved Domains (1) summary
      cl00042
      Location:1 → 248
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    RNA

    1. XR_004941347.1 RNA Sequence

    2. XR_004941339.1 RNA Sequence

    3. XR_004941341.1 RNA Sequence

    4. XR_003954342.2 RNA Sequence

    5. XR_004941344.1 RNA Sequence

    6. XR_004941343.1 RNA Sequence

    7. XR_004941346.1 RNA Sequence

    8. XR_004941338.1 RNA Sequence

    9. XR_004941345.1 RNA Sequence

    10. XR_004941342.1 RNA Sequence

    11. XR_004941340.1 RNA Sequence

    12. XR_003954341.2 RNA Sequence

    13. XR_004941348.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXY9.2 GenPept UniProtKB/Swiss-Prot:Q9CXY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous