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    Tshb thyroid stimulating hormone, beta subunit [ Mus musculus (house mouse) ]

    Gene ID: 22094, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tshbprovided by MGI
    Official Full Name
    thyroid stimulating hormone, beta subunitprovided by MGI
    Primary source
    MGI:MGI:98848
    See related
    Ensembl:ENSMUSG00000027857 AllianceGenome:MGI:98848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable hormone activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cytoplasm. Is expressed in brain. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 4 and hypothyroidism. Orthologous to human TSHB (thyroid stimulating hormone subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Tshb in Genome Data Viewer
    Location:
    3 F2.2; 3 45.25 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (102684621..102718175, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (102777398..102789082, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3456 Neighboring gene predicted gene, 40112 Neighboring gene STARR-seq mESC enhancer starr_08578 Neighboring gene tetraspanin 2, opposite strand Neighboring gene tetraspanin 2 Neighboring gene STARR-seq mESC enhancer starr_08579 Neighboring gene STARR-positive B cell enhancer mm9_chr3:102608013-102608314 Neighboring gene synaptonemal complex protein 1 Neighboring gene STARR-seq mESC enhancer starr_08580 Neighboring gene predicted gene, 33866 Neighboring gene STARR-positive B cell enhancer ABC_E11206 Neighboring gene nuclear receptor subfamily 1, group H, member 5 Neighboring gene predicted gene, 22826

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting oncogenesis by introduction of a 5.2-kbp segment of the 5' regulatory region of the human thyrotropin beta-subunit gene. Miyoshi I, et al. Endocr Res, 2001 Nov. PMID 11794463
    2. Organization and nucleotide sequence of the gene encoding the beta-subunit of murine thyrotropin. Gordon DF, et al. DNA, 1988 Jan-Feb. PMID 3349902
    3. Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection. Weber A, et al. Gen Comp Endocrinol, 2020 Aug 1. PMID 32360559, Free PMC Article
    4. Regulation of the alpha and thyrotropin beta-subunit messenger ribonucleic acids by thyroid hormones. Chin WW, et al. Endocrinology, 1985 Mar. PMID 2578951
    5. Bone marrow cells produce a novel TSHbeta splice variant that is upregulated in the thyroid following systemic virus infection. Vincent BH, et al. Genes Immun, 2009 Jan. PMID 18754015, Free PMC Article

    See all (200) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thyroid stimulating hormone beta-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection.
      Title: Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection.
    2. TSH, as an independent risk factor of atherosclerosis, aggravates vascular inflammation and contributes to atherogenesis.
      Title: Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.
    3. subcutaneous adipose tissue Tshb expression levels correlated directly with circulating cholesterol levels
      Title: TSHB mRNA is linked to cholesterol metabolism in adipose tissue.
    4. Oncogene-induced senescence is initiated in Braf(V600E)-induced papillary thyroid cancers when TSH is normal. TSH reduces p53 expression by upregulating the PI3K/AKT pathway and inhibiting OIS, resulting in tumor progression.
      Title: TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer.
    5. The observations indicate that the experimental system possesses responsiveness of the TSHbeta expression to melatonin.
      Title: Establishment of TSH β real-time monitoring system in mammalian photoperiodism.
    6. PPARalpha modulates the TSH beta-subunit mRNA expression in thyrotrope cells.
      Title: PPARα modulates the TSH β-subunit mRNA expression in thyrotrope TαT1 cells and in a mouse model.
    7. Tshb gene transcription was attenuated in MED1 mutant mice in which the nuclear receptor-binding ability of MED1 was specifically disrupted.
      Title: Mediator subunit MED1 is a T3-dependent and T3-independent coactivator on the thyrotropin β gene promoter.
    8. Disruption of type II deiodinase in thyrotrophs decreases their sensitivity to T4 thyroid hormone and thus elevates serum TSH.
      Title: Coordination of hypothalamic and pituitary T3 production regulates TSH expression.
    9. Thyrotropin-releasing hormone altered the basal expression of the TSHbeta gene and the responsiveness of the gene to thyroid hormone.
      Title: NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin β gene: analysis of TRH knockout mice.
    10. PBF is the first protein to interact with the critical TH transporter MCT8 and modulate its function in vivo
      Title: PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC151206, MGC151208

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    thyrotropin subunit beta
    Names
    TSH-B
    TSH-beta
    thyroid-stimulating hormone subunit beta
    thyrotropin beta chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165939.1 → NP_001159411.1  thyrotropin subunit beta precursor

      See identical proteins and their annotated locations for NP_001159411.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC134871
      Consensus CDS
      CCDS17689.1
      UniProtKB/Swiss-Prot
      P12656
      UniProtKB/TrEMBL
      E9Q4F3, Q14AI3
      Related
      ENSMUSP00000128440.2, ENSMUST00000172026.8
      Conserved Domains (1) summary
      smart00068
      Location:20 → 126
      GHB; Glycoprotein hormone beta chain homologues

    2. NM_001165940.1 → NP_001159412.1  thyrotropin subunit beta precursor

      See identical proteins and their annotated locations for NP_001159412.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. An in-frame AUG is located 17 codons upstream of the annotated translation start site but is not being annotated as a start site since it would disrupt the signal peptide on NP_001159412.1.
      Source sequence(s)
      AC134871
      Consensus CDS
      CCDS17689.1
      UniProtKB/Swiss-Prot
      P12656
      UniProtKB/TrEMBL
      E9Q4F3, Q14AI3
      Related
      ENSMUSP00000127165.2, ENSMUST00000170856.6
      Conserved Domains (1) summary
      smart00068
      Location:20 → 126
      GHB; Glycoprotein hormone beta chain homologues

    3. NM_009432.2 → NP_033458.2  thyrotropin subunit beta precursor

      See identical proteins and their annotated locations for NP_033458.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC134871
      Consensus CDS
      CCDS17689.1
      UniProtKB/Swiss-Prot
      P12656
      UniProtKB/TrEMBL
      E9Q4F3, Q14AI3
      Related
      ENSMUSP00000029450.4, ENSMUST00000029450.10
      Conserved Domains (1) summary
      smart00068
      Location:20 → 126
      GHB; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      102684621..102718175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501305.5 → XP_006501368.1  thyrotropin subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006501368.1

      UniProtKB/Swiss-Prot
      P12656
      UniProtKB/TrEMBL
      E9Q4F3, Q14AI3
      Conserved Domains (1) summary
      smart00068
      Location:20 → 126
      GHB; Glycoprotein hormone beta chain homologues

    2. XM_006501304.5 → XP_006501367.1  thyrotropin subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006501367.1

      UniProtKB/Swiss-Prot
      P12656
      UniProtKB/TrEMBL
      E9Q4F3, Q14AI3
      Conserved Domains (1) summary
      smart00068
      Location:20 → 126
      GHB; Glycoprotein hormone beta chain homologues

    3. XM_036163022.1 → XP_036018915.1  thyrotropin subunit beta isoform X1

      UniProtKB/Swiss-Prot
      P12656
      UniProtKB/TrEMBL
      E9Q4F3, Q14AI3
      Conserved Domains (1) summary
      smart00068
      Location:20 → 126
      GHB; Glycoprotein hormone beta chain homologues

    4. XM_017319535.3 → XP_017175024.1  thyrotropin subunit beta isoform X1

      UniProtKB/Swiss-Prot
      P12656
      UniProtKB/TrEMBL
      E9Q4F3, Q14AI3
      Conserved Domains (1) summary
      smart00068
      Location:20 → 126
      GHB; Glycoprotein hormone beta chain homologues
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12656.1 GenPept UniProtKB/Swiss-Prot:P12656

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