Naa60 N(alpha)-acetyltransferase 60, NatF catalytic subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Naa60provided by MGI
Official Full Name: N(alpha)-acetyltransferase 60, NatF catalytic subunitprovided by MGI
Primary source: MGI:MGI:1922013
See related: Ensembl:ENSMUSG00000005982 AllianceGenome:MGI:1922013
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HAT4; NatF; Nat15; 1200013P24Rik
Summary: Predicted to enable histone H4 acetyltransferase activity; peptide alpha-N-acetyltransferase activity; and protein homodimerization activity. Predicted to be involved in several processes, including N-terminal peptidyl-methionine acetylation; chromosome segregation; and nucleosome assembly. Predicted to be active in Golgi membrane. Orthologous to human NAA60 (N-alpha-acetyltransferase 60, NatF catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 39.1), mammary gland adult (RPKM 28.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.28 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (3690365..3722645)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (3872496..3904781)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

General gene information

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Markers

AI315146 (e-PCR)
- UniSTS:160517

NoName (e-PCR)
- UniSTS:237413

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K122 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K18 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide alpha-N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide alpha-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide alpha-N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide-methionine-alpha-N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-methionine acetylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-methionine acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal protein amino acid acetylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal protein amino acid acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: N-alpha-acetyltransferase 60

Names: N-acetyltransferase 15 (GCN5-related, putative); N-alpha-acetyltransferase F; histone acetyltransferase type B protein 4; natF catalytic subunit

NP_001277618.1

EC 2.3.1.259

EC 2.3.1.48

NP_083366.1

EC 2.3.1.259

EC 2.3.1.48

XP_006522742.1

EC 2.3.1.259

EC 2.3.1.48

XP_006522743.1

EC 2.3.1.259

EC 2.3.1.48

XP_017172644.1

EC 2.3.1.259

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290689.1 → NP_001277618.1 N-alpha-acetyltransferase 60 isoform 2

See identical proteins and their annotated locations for NP_001277618.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC129021, AI035720, AI448494, AK004750

Consensus CDS

CCDS70676.1

UniProtKB/TrEMBL

H3BIY0

Related

ENSMUSP00000134768.2, ENSMUST00000176625.8

Conserved Domains (2) summary

pfam00583
Location:12 → 90

Acetyltransf_1; Acetyltransferase (GNAT) family

cl21457
Location:74 → 138

TIM; TIM-like beta/alpha barrel domains
NM_029090.3 → NP_083366.1 N-alpha-acetyltransferase 60 isoform 1

See identical proteins and their annotated locations for NP_083366.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC129021, BG147816, BI739241, BY255312, CF540715

Consensus CDS

CCDS37239.1

UniProtKB/Swiss-Prot

Q9DBU2

Related

ENSMUSP00000140031.2, ENSMUST00000186375.8

Conserved Domains (2) summary

pfam00583
Location:23 → 155

Acetyltransf_1; Acetyltransferase (GNAT) family

cl21457
Location:139 → 203

TIM; TIM-like beta/alpha barrel domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

3690365..3722645

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522680.4 → XP_006522743.1 N-alpha-acetyltransferase 60 isoform X1

See identical proteins and their annotated locations for XP_006522743.1

UniProtKB/Swiss-Prot

Q9DBU2

Related

ENSMUSP00000135206.2, ENSMUST00000150655.3

Conserved Domains (2) summary

pfam00583
Location:23 → 155

Acetyltransf_1; Acetyltransferase (GNAT) family

cl21457
Location:139 → 203

TIM; TIM-like beta/alpha barrel domains
XM_017317155.2 → XP_017172644.1 N-alpha-acetyltransferase 60 isoform X2

UniProtKB/TrEMBL

H3BJZ6

Related

ENSMUSP00000135188.2, ENSMUST00000143537.9

Conserved Domains (1) summary

cl17182
Location:23 → 113

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
XM_006522679.3 → XP_006522742.1 N-alpha-acetyltransferase 60 isoform X1

See identical proteins and their annotated locations for XP_006522742.1

UniProtKB/Swiss-Prot

Q9DBU2

Conserved Domains (2) summary

pfam00583
Location:23 → 155

Acetyltransf_1; Acetyltransferase (GNAT) family

cl21457
Location:139 → 203

TIM; TIM-like beta/alpha barrel domains