Mast4 microtubule associated serine/threonine kinase family member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mast4provided by MGI
Official Full Name: microtubule associated serine/threonine kinase family member 4provided by MGI
Primary source: MGI:MGI:1918885
See related: Ensembl:ENSMUSG00000034751 AllianceGenome:MGI:1918885
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0303; 4930420O11Rik
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization and intracellular signal transduction. Predicted to be located in cytoplasm. Is expressed in brain; thymus primordium; and ventral grey horn. Orthologous to human MAST4 (microtubule associated serine/threonine kinase family member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 6.5), bladder adult (RPKM 6.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 54.94 cM

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (102868996..103471607, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (102732486..103335099, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis.
Title: MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis.
MAST4 controls cell cycle in spermatogonial stem cells.
Title: MAST4 controls cell cycle in spermatogonial stem cells.
Mast4 determines the cell fate of MSCs for bone and cartilage development.
Title: Mast4 determines the cell fate of MSCs for bone and cartilage development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI462951 (e-PCR)
- UniSTS:165890

NoName (e-PCR)
- UniSTS:237098

D13Mit226 (e-PCR), detects polymorphism
- UniSTS:127040

D13Mit234 (e-PCR), detects polymorphism
- UniSTS:127049

BE692023 (e-PCR)
- UniSTS:208978

BB462437 (e-PCR)
- UniSTS:208979

09.MMHAP36FRC9.seq (e-PCR)
- UniSTS:122975

AI642422 (e-PCR)
- UniSTS:180593

D13Mit290 (e-PCR), detects polymorphism
- UniSTS:127110

45.MMHAP5FRG12.seq (e-PCR)
- UniSTS:124584

RH136381 (e-PCR)
- UniSTS:210371

D13Ertd776e (e-PCR), detects polymorphism
- UniSTS:167124

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microtubule-associated serine/threonine-protein kinase 4

NP_780380.2

EC 2.7.11.1

XP_006517764.1

EC 2.7.11.1

XP_006517765.1

EC 2.7.11.1

XP_006517766.1

EC 2.7.11.1

XP_006517767.1

EC 2.7.11.1

XP_006517768.1

EC 2.7.11.1

XP_006517769.1

EC 2.7.11.1

XP_006517770.1

EC 2.7.11.1

XP_011242974.1

EC 2.7.11.1

XP_011242975.1

EC 2.7.11.1

XP_011242976.1

EC 2.7.11.1

XP_017171016.1

EC 2.7.11.1

XP_017171017.1

EC 2.7.11.1

XP_017171018.1

EC 2.7.11.1

XP_017171019.1

EC 2.7.11.1

XP_017171020.1

EC 2.7.11.1

XP_017171021.1

EC 2.7.11.1

XP_030103167.1

EC 2.7.11.1

XP_030103168.1

EC 2.7.11.1

XP_030103169.1

EC 2.7.11.1

XP_030103170.1

EC 2.7.11.1

XP_036013969.1

EC 2.7.11.1

XP_036013970.1

EC 2.7.11.1

XP_036013971.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175171.3 → NP_780380.2 microtubule-associated serine/threonine-protein kinase 4

See identical proteins and their annotated locations for NP_780380.2

Status: VALIDATED

Source sequence(s)

AC112791, AC114827, AC124387, AC165290, AC167975, AC239606

Consensus CDS

CCDS49349.1

UniProtKB/Swiss-Prot

E9QAH7, Q3UVE7, Q62489, Q6ZQE0, Q811L6, Q8BME3

Related

ENSMUSP00000128464.2, ENSMUST00000167058.8

Conserved Domains (4) summary

smart00220
Location:568 → 841

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1144 → 1222

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:567 → 846

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:256 → 529

DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

102868996..103471607 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315531.2 → XP_017171020.1 microtubule-associated serine/threonine-protein kinase 4 isoform X5

Conserved Domains (3) summary

cd00992
Location:1147 → 1225

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:570 → 849

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:256 → 532

DUF1908; Domain of unknown function (DUF1908)
XM_017315530.2 → XP_017171019.1 microtubule-associated serine/threonine-protein kinase 4 isoform X4

Conserved Domains (3) summary

cd00992
Location:1159 → 1237

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:582 → 861

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:268 → 544

DUF1908; Domain of unknown function (DUF1908)
XM_017315529.2 → XP_017171018.1 microtubule-associated serine/threonine-protein kinase 4 isoform X3

Conserved Domains (3) summary

cd00992
Location:1172 → 1250

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:595 → 874

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:281 → 557

DUF1908; Domain of unknown function (DUF1908)
XM_017315528.2 → XP_017171017.1 microtubule-associated serine/threonine-protein kinase 4 isoform X2

Conserved Domains (3) summary

cd00992
Location:1181 → 1259

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:604 → 883

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:293 → 566

DUF1908; Domain of unknown function (DUF1908)
XM_017315532.2 → XP_017171021.1 microtubule-associated serine/threonine-protein kinase 4 isoform X6

Conserved Domains (3) summary

cd00992
Location:1117 → 1195

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:607 → 886

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:293 → 569

DUF1908; Domain of unknown function (DUF1908)
XM_017315527.2 → XP_017171016.1 microtubule-associated serine/threonine-protein kinase 4 isoform X1

Conserved Domains (3) summary

cd00992
Location:1184 → 1262

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:607 → 886

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:293 → 569

DUF1908; Domain of unknown function (DUF1908)
XM_036158077.1 → XP_036013970.1 microtubule-associated serine/threonine-protein kinase 4 isoform X22

Conserved Domains (3) summary

cd00992
Location:878 → 956

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:368 → 647

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:57 → 330

DUF1908; Domain of unknown function (DUF1908)
XM_006517705.5 → XP_006517768.1 microtubule-associated serine/threonine-protein kinase 4 isoform X17

Conserved Domains (3) summary

cd00992
Location:945 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:368 → 647

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:57 → 330

DUF1908; Domain of unknown function (DUF1908)
XM_006517704.5 → XP_006517767.1 microtubule-associated serine/threonine-protein kinase 4 isoform X16

Conserved Domains (3) summary

cd00992
Location:948 → 1026

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:371 → 650

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:57 → 333

DUF1908; Domain of unknown function (DUF1908)
XM_030247309.2 → XP_030103169.1 microtubule-associated serine/threonine-protein kinase 4 isoform X13

UniProtKB/TrEMBL

A0A0A6YXG1

Related

ENSMUSP00000141977.3, ENSMUST00000194446.7

Conserved Domains (3) summary

cd00992
Location:957 → 1035

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:380 → 659

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:69 → 342

DUF1908; Domain of unknown function (DUF1908)
XM_006517702.5 → XP_006517765.1 microtubule-associated serine/threonine-protein kinase 4 isoform X12

Conserved Domains (3) summary

cd00992
Location:960 → 1038

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:383 → 662

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:69 → 345

DUF1908; Domain of unknown function (DUF1908)
XM_030247307.2 → XP_030103167.1 microtubule-associated serine/threonine-protein kinase 4 isoform X9

UniProtKB/TrEMBL

A0A668KMA1

Related

ENSMUSP00000159269.2, ENSMUST00000239261.2

Conserved Domains (3) summary

cd00992
Location:970 → 1048

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:393 → 672

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:82 → 355

DUF1908; Domain of unknown function (DUF1908)
XM_036158076.1 → XP_036013969.1 microtubule-associated serine/threonine-protein kinase 4 isoform X8

Conserved Domains (3) summary

cd00992
Location:973 → 1051

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:396 → 675

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:82 → 358

DUF1908; Domain of unknown function (DUF1908)
XM_006517701.5 → XP_006517764.1 microtubule-associated serine/threonine-protein kinase 4 isoform X7

Conserved Domains (3) summary

cd00992
Location:985 → 1063

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:408 → 687

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:94 → 370

DUF1908; Domain of unknown function (DUF1908)
XM_006517706.4 → XP_006517769.1 microtubule-associated serine/threonine-protein kinase 4 isoform X18

Conserved Domains (3) summary

cd00992
Location:940 → 1018

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:363 → 642

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:49 → 325

DUF1908; Domain of unknown function (DUF1908)
XM_030247308.2 → XP_030103168.1 microtubule-associated serine/threonine-protein kinase 4 isoform X11

Conserved Domains (3) summary

cd00992
Location:964 → 1042

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:387 → 666

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:76 → 349

DUF1908; Domain of unknown function (DUF1908)
XM_011244672.3 → XP_011242974.1 microtubule-associated serine/threonine-protein kinase 4 isoform X10

UniProtKB/TrEMBL

E9QPR4

Related

ENSMUSP00000096808.4, ENSMUST00000099202.10

Conserved Domains (3) summary

cd00992
Location:967 → 1045

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:390 → 669

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:76 → 352

DUF1908; Domain of unknown function (DUF1908)
XM_030247310.2 → XP_030103170.1 microtubule-associated serine/threonine-protein kinase 4 isoform X19

Conserved Domains (3) summary

cd00992
Location:937 → 1015

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:360 → 639

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:49 → 322

DUF1908; Domain of unknown function (DUF1908)
XM_011244673.4 → XP_011242975.1 microtubule-associated serine/threonine-protein kinase 4 isoform X15

UniProtKB/TrEMBL

E9PWX8

Related

ENSMUSP00000131651.2, ENSMUST00000171791.8

Conserved Domains (3) summary

cd00992
Location:952 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:375 → 654

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:64 → 337

DUF1908; Domain of unknown function (DUF1908)
XM_006517703.5 → XP_006517766.1 microtubule-associated serine/threonine-protein kinase 4 isoform X14

Conserved Domains (3) summary

cd00992
Location:955 → 1033

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:378 → 657

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:64 → 340

DUF1908; Domain of unknown function (DUF1908)
XM_011244674.4 → XP_011242976.1 microtubule-associated serine/threonine-protein kinase 4 isoform X21

Conserved Domains (3) summary

cd00992
Location:885 → 963

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:375 → 654

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:64 → 337

DUF1908; Domain of unknown function (DUF1908)
XM_036158078.1 → XP_036013971.1 microtubule-associated serine/threonine-protein kinase 4 isoform X23

Conserved Domains (3) summary

cd00992
Location:798 → 876

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:221 → 500

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:1 → 183

DUF1908; Domain of unknown function (DUF1908)
XM_006517707.4 → XP_006517770.1 microtubule-associated serine/threonine-protein kinase 4 isoform X20

Conserved Domains (3) summary

cd00992
Location:937 → 1015

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:360 → 639

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:46 → 322

DUF1908; Domain of unknown function (DUF1908)