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    C2orf92 chromosome 2 open reading frame 92 [ Homo sapiens (human) ]

    Gene ID: 728537, updated on 2-Nov-2024

    Summary

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    Official Symbol
    C2orf92provided by HGNC
    Official Full Name
    chromosome 2 open reading frame 92provided by HGNC
    Primary source
    HGNC:HGNC:49272
    See related
    Ensembl:ENSG00000228486 AllianceGenome:HGNC:49272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINC01125
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 7.5), skin (RPKM 1.9) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C2orf92 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (97663941..97703066)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (98122162..98161282)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (98286176..98319529)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98261483-98262417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16239 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:98278969-98279610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11793 Neighboring gene U4 spliceosomal RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16241 Neighboring gene UBTF like 6 (pseudogene) Neighboring gene cytochrome c oxidase subunit 5B Neighboring gene actin related protein 1B Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:98304422-98305621 Neighboring gene RNA, U4 small nuclear 8, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98307157-98307956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98323640-98324200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98324201-98324759 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:98327684-98327873 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98329847-98330820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98332052-98332567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98332568-98333082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98340736-98341326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98356023-98356522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11794 Neighboring gene zeta chain of T cell receptor associated protein kinase 70 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98379903-98380684 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:98386577-98387090 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:98387091-98387603 Neighboring gene uncharacterized LOC124907861 Neighboring gene transmembrane protein 131

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Discovery of a novel linc01125 isoform in serum exosomes as a promising biomarker for NSCLC diagnosis and survival assessment. Xian J, et al. Carcinogenesis, 2021 Jun 21. PMID 33928340
    2. m6A Writer METTL3-Mediated lncRNA LINC01125 Prevents the Malignancy of Papillary Thyroid Cancer. He T, et al. Crit Rev Immunol, 2023. PMID 37824376
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. m6A Writer METTL3-Mediated lncRNA LINC01125 Prevents the Malignancy of Papillary Thyroid Cancer.
      Title: m6A Writer METTL3-Mediated lncRNA LINC01125 Prevents the Malignancy of Papillary Thyroid Cancer.
    2. Discovery of a novel linc01125 isoform in serum exosomes as a promising biomarker for NSCLC diagnosis and survival assessment.
      Title: Discovery of a novel linc01125 isoform in serum exosomes as a promising biomarker for NSCLC diagnosis and survival assessment.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Clone Names

    • AC017099.3

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein C2orf92
    Names
    long intergenic non-protein coding RNA 1125

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351368.2 → NP_001338297.1  uncharacterized protein C2orf92 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC017099
      Consensus CDS
      CCDS86862.1
      UniProtKB/Swiss-Prot
      A0A1B0GVN3
      Related
      ENSP00000490587.1, ENST00000627399.4

    2. NM_001410919.1 → NP_001397848.1  uncharacterized protein C2orf92 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC017099
      Consensus CDS
      CCDS92816.1
      UniProtKB/TrEMBL
      A0A1B0GW88
      Related
      ENSP00000490827.1, ENST00000599501.6

    RNA

    1. NR_038386.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA448462, AC017099, AI637498, BC039374, DB066031
      Related
      ENST00000451384.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      97663941..97703066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453105.2 → XP_024308873.1  uncharacterized protein C2orf92 isoform X1

    2. XM_024453109.2 → XP_024308877.1  uncharacterized protein C2orf92 isoform X3

    3. XM_024453106.2 → XP_024308874.1  uncharacterized protein C2orf92 isoform X2

    4. XM_024453113.2 → XP_024308881.1  uncharacterized protein C2orf92 isoform X7

    5. XM_024453110.2 → XP_024308878.1  uncharacterized protein C2orf92 isoform X4

    6. XM_024453111.2 → XP_024308879.1  uncharacterized protein C2orf92 isoform X5

    7. XM_047445723.1 → XP_047301679.1  uncharacterized protein C2orf92 isoform X6

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791765.1 Reference GRCh38.p14 PATCHES

      Range
      589972..629097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332989.1 → XP_054188964.1  uncharacterized protein C2orf92 isoform X1

    2. XM_054332991.1 → XP_054188966.1  uncharacterized protein C2orf92 isoform X3

    3. XM_054332990.1 → XP_054188965.1  uncharacterized protein C2orf92 isoform X2

    4. XM_054332995.1 → XP_054188970.1  uncharacterized protein C2orf92 isoform X7

    5. XM_054332992.1 → XP_054188967.1  uncharacterized protein C2orf92 isoform X4

    6. XM_054332993.1 → XP_054188968.1  uncharacterized protein C2orf92 isoform X5

    7. XM_054332994.1 → XP_054188969.1  uncharacterized protein C2orf92 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      98122162..98161282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343707.1 → XP_054199682.1  uncharacterized protein C2orf92 isoform X1

    2. XM_054343709.1 → XP_054199684.1  uncharacterized protein C2orf92 isoform X3

    3. XM_054343708.1 → XP_054199683.1  uncharacterized protein C2orf92 isoform X2

    4. XM_054343713.1 → XP_054199688.1  uncharacterized protein C2orf92 isoform X7

    5. XM_054343710.1 → XP_054199685.1  uncharacterized protein C2orf92 isoform X4

    6. XM_054343711.1 → XP_054199686.1  uncharacterized protein C2orf92 isoform X5

    7. XM_054343712.1 → XP_054199687.1  uncharacterized protein C2orf92 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1B0GVN3.1 GenPept UniProtKB/Swiss-Prot:A0A1B0GVN3

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