YAP1 Yes1 associated transcriptional regulator [Homo sapiens (human)] - Gene

Summary

Official Symbol: YAP1provided by HGNC
Official Full Name: Yes1 associated transcriptional regulatorprovided by HGNC
Primary source: HGNC:HGNC:16262
See related: Ensembl:ENSG00000137693 MIM:606608; AllianceGenome:HGNC:16262
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: YAP; YKI; COB1; YAP2; YAP-1; YAP65
Summary: This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
Expression: Ubiquitous expression in thyroid (RPKM 45.0), endometrium (RPKM 38.7) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q22.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (102110447..102233424)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (102112538..102235509)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (101981178..102104155)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of YAP1 and other transcription factors contributes to lineage plasticity in combined small cell lung carcinoma.
Title: The expression of YAP1 and other transcription factors contributes to lineage plasticity in combined small cell lung carcinoma.
The RNA helicase DDX21 activates YAP to promote tumorigenesis and is transcriptionally upregulated by beta-catenin in colorectal cancer.
Title: The RNA helicase DDX21 activates YAP to promote tumorigenesis and is transcriptionally upregulated by β-catenin in colorectal cancer.
SENP3 mediates the deSUMOylation and degradation of YAP1 to regulate the progression of triple-negative breast cancer.
Title: SENP3 mediates the deSUMOylation and degradation of YAP1 to regulate the progression of triple-negative breast cancer.
Circ_0002722-induced regulation of YAP promotes platinum resistance in oral squamous cell carcinoma: Implications for verteporfin therapy.
Title: Circ_0002722-induced regulation of YAP promotes platinum resistance in oral squamous cell carcinoma: Implications for verteporfin therapy.
Arp2/3 complex activity enables nuclear YAP for naive pluripotency of human embryonic stem cells.
Title: Arp2/3 complex activity enables nuclear YAP for naïve pluripotency of human embryonic stem cells.
HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14.
Title: HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14.
Ku70 Binding to YAP Alters PARP1 Ubiquitination to Regulate Genome Stability and Tumorigenesis.
Title: Ku70 Binding to YAP Alters PARP1 Ubiquitination to Regulate Genome Stability and Tumorigenesis.
EIF4A3-Induced Upregulation of hsa_circ_0049396 Attenuates the Tumorigenesis of Nasopharyngeal Carcinoma by Regulating the Hippo-YAP Pathway.
Title: EIF4A3-Induced Upregulation of hsa_circ_0049396 Attenuates the Tumorigenesis of Nasopharyngeal Carcinoma by Regulating the Hippo-YAP Pathway.
LncRNA HOTAIR promotes the migration and invasion of cervical cancer through DNMT3B/LATS1/ YAP1 pS127 axis.
Title: LncRNA HOTAIR promotes the migration and invasion of cervical cancer through DNMT3B/LATS1/ YAP1 pS127 axis.
HPV-YAP1 oncogenic alliance drives malignant transformation of fallopian tube epithelial cells.
Title: HPV-YAP1 oncogenic alliance drives malignant transformation of fallopian tube epithelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (1296)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Uveal coloboma-cleft lip and palate-intellectual disability MedGen: C3805432 OMIM: 120433 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2014-11-13) ClinGen Genome Curation Page Haploinsufficency Little evidence for dosage pathogenicity (Last evaluated 2014-11-13) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2249E (e-PCR)
- UniSTS:31753

RH41050 (e-PCR)
- UniSTS:91659

RH91842 (e-PCR)
- UniSTS:84305

RH123128 (e-PCR)
- UniSTS:135509

D11S1339 (e-PCR), detects polymorphism
- UniSTS:19847

RH47129 (e-PCR)
- UniSTS:83859

HUM000S656 (e-PCR)
- UniSTS:28321

SHGC-110032 (e-PCR)
- UniSTS:170169

D11S1339 (e-PCR), detects polymorphism
- UniSTS:73445

D11S1762 (e-PCR)
- UniSTS:6386

SHGC-32695 (e-PCR)
- UniSTS:167674

SHGC-77975 (e-PCR)
- UniSTS:101373

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables proline-rich region binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in bud elongation involved in lung branching	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle tissue regeneration	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to gamma radiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in embryonic heart tube morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in enterocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glandular epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in heart process	IEA Inferred from Electronic Annotation more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in hippo signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in hippo signaling	TAS Traceable Author Statement more info	PubMed
involved_in interleukin-6-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intestinal epithelial cell development	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in lateral mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in lung epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in notochord development	IEA Inferred from Electronic Annotation more info
involved_in organ growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in paraxial mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in polarized epithelial cell differentiation	IC Inferred by Curator more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of metanephric nephron tubule epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neurogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to progesterone	IDA Inferred from Direct Assay more info	PubMed
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in tissue homeostasis	IEA Inferred from Electronic Annotation more info
involved_in trophectodermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in vasculogenesis	IEA Inferred from Electronic Annotation more info
involved_in wound healing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of TEAD-YAP complex	IDA Inferred from Direct Assay more info	PubMed
part_of TEAD-YAP complex	IPI Inferred from Physical Interaction more info	PubMed
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	IDA Inferred from Direct Assay more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in female germ cell nucleus	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcriptional coactivator YAP1

Names: 65 kDa Yes-associated protein; Yes associated protein 1; protein yorkie homolog; yes-associated protein 2; yes-associated protein YAP65 homolog; yorkie homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029530.2 RefSeqGene

Range

4987..127964

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001130145.3 → NP_001123617.1 transcriptional coactivator YAP1 isoform 1

See identical proteins and their annotated locations for NP_001123617.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 9. The encoded protein (isoform 1) represents the YAP1-2gamma isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.

Source sequence(s)

AI128142, AL832620, AP000942, AP001527, BC038235

Consensus CDS

CCDS44716.1

UniProtKB/Swiss-Prot

B4DTY1, B7ZA01, E3WEB5, E3WEB6, E9PRV2, F5H202, K0KQ18, K0KYZ8, K0L195, K0L1G3, P46937, Q7Z574, Q8IUY9

Related

ENSP00000282441.5, ENST00000282441.10

Conserved Domains (2) summary

cd00201
Location:174 → 203

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:232 → 261

WW; WW domain
NM_001195044.2 → NP_001181973.1 transcriptional coactivator YAP1 isoform 3

See identical proteins and their annotated locations for NP_001181973.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate exon in the 3' coding region, compared to variant 9. The encoded protein (isoform 3) represents the YAP1-2alpha isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.

Source sequence(s)

AI128142, AL832620, AP000942, AP001527, AY316529

Consensus CDS

CCDS53699.1

UniProtKB/Swiss-Prot

P46937

UniProtKB/TrEMBL

Q86T74

Related

ENSP00000431574.1, ENST00000531439.5

Conserved Domains (2) summary

cd00201
Location:174 → 203

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:232 → 261

WW; WW domain
NM_001195045.2 → NP_001181974.1 transcriptional coactivator YAP1 isoform 4

See identical proteins and their annotated locations for NP_001181974.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region, compared to variant 9. These differences cause translation initiation at a downstream AUG and result in a shorter isoform (4), compared to isoform 9.

Source sequence(s)

AA854862, AI128142, AK316116, AL832620, AP000942, BC038235

Consensus CDS

CCDS53700.1

UniProtKB/TrEMBL

Q86T74

Related

ENSP00000435602.1, ENST00000524575.5

Conserved Domains (2) summary

cd00201
Location:1 → 25

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:54 → 83

WW; WW domain
NM_001282097.2 → NP_001269026.1 transcriptional coactivator YAP1 isoform 6

See identical proteins and their annotated locations for NP_001269026.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 9. The encoded protein (isoform 6) represents the YAP1-1gamma isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.

Source sequence(s)

AB567720, AI128142, AL832620, AP000942, AP001527, BC026212

UniProtKB/Swiss-Prot

P46937

UniProtKB/TrEMBL

Q86T74

Conserved Domains (1) summary

cd00201
Location:174 → 203

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
NM_001282098.2 → NP_001269027.1 transcriptional coactivator YAP1 isoform 5

See identical proteins and their annotated locations for NP_001269027.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region, compared to variant 9. The encoded protein (isoform 5) represents the YAP1-1beta isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.

Source sequence(s)

AI128142, AL832620, AP000942, AP001527, BC026212, BC038235, HE864159

Consensus CDS

CCDS60945.1

Related

ENSP00000487519.1, ENST00000629586.2

Conserved Domains (1) summary

cd00201
Location:174 → 203

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
NM_001282099.2 → NP_001269028.1 transcriptional coactivator YAP1 isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an alternate in-frame exon in the coding region, compared to variant 9. The encoded protein (isoform 7) represents the YAP1-1delta isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.

Source sequence(s)

AI128142, AL832620, AP000942, AP001527, BC026212, BC038235, HE864161

Consensus CDS

CCDS73374.1

UniProtKB/Swiss-Prot

P46937

UniProtKB/TrEMBL

Q86T74

Related

ENSP00000331023.4, ENST00000345877.6

Conserved Domains (1) summary

cd00201
Location:174 → 203

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
NM_001282100.2 → NP_001269029.1 transcriptional coactivator YAP1 isoform 8

See identical proteins and their annotated locations for NP_001269029.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks an alternate in-frame exon in the 3' coding region, compared to variant 9. The encoded protein (isoform 8) represents the YAP1-2beta isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.

Source sequence(s)

AB567720, AI128142, AL832620, AP000942, AP001527, BC026212, BC038235, HE864162

Consensus CDS

CCDS60944.1

UniProtKB/Swiss-Prot

P46937

UniProtKB/TrEMBL

Q86T74

Related

ENSP00000445635.1, ENST00000537274.5

Conserved Domains (2) summary

cd00201
Location:174 → 203

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:232 → 261

WW; WW domain
NM_001282101.2 → NP_001269030.1 transcriptional coactivator YAP1 isoform 9

See identical proteins and their annotated locations for NP_001269030.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) represents the longest transcript and encodes the longest isoform (9). The encoded protein represents the YAP1-2delta isoform described in Figure 3 of PMID: 22939869.

Source sequence(s)

AI128142, AL832620, AP000942, AP001527, BC026212, BC038235, HE864163

Consensus CDS

CCDS73373.1

UniProtKB/Swiss-Prot

P46937

UniProtKB/TrEMBL

K0KVU2, Q86T74

Related

ENSP00000478927.1, ENST00000615667.4

Conserved Domains (2) summary

cd00201
Location:174 → 203

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:232 → 261

WW; WW domain
NM_006106.5 → NP_006097.2 transcriptional coactivator YAP1 isoform 2

See identical proteins and their annotated locations for NP_006097.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks two alternate exons in the coding region, compared to variant 9. The encoded protein (isoform 2) represents the YAP1-1alpha isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.

Source sequence(s)

AI128142, AL832620, AP000942, AP001527, AP002777

Consensus CDS

CCDS8314.2

UniProtKB/TrEMBL

Q86T74

Related

ENSP00000434134.1, ENST00000526343.5

Conserved Domains (1) summary

cd00201
Location:174 → 203

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

102110447..102233424

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005271378.4 → XP_005271435.1 transcriptional coactivator YAP1 isoform X1

Conserved Domains (2) summary

cd00201
Location:174 → 203

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:232 → 261

WW; WW domain
XM_005271381.4 → XP_005271438.1 transcriptional coactivator YAP1 isoform X3

Conserved Domains (2) summary

cd00201
Location:174 → 203

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:232 → 261

WW; WW domain
XM_005271380.4 → XP_005271437.1 transcriptional coactivator YAP1 isoform X2

See identical proteins and their annotated locations for XP_005271437.1

Conserved Domains (2) summary

cd00201
Location:174 → 203

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:232 → 261

WW; WW domain
XM_005271383.4 → XP_005271440.1 transcriptional coactivator YAP1 isoform X4

See identical proteins and their annotated locations for XP_005271440.1

Conserved Domains (2) summary

cd00201
Location:174 → 203

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:232 → 261

WW; WW domain
XM_011542555.3 → XP_011540857.1 transcriptional coactivator YAP1 isoform X5

See identical proteins and their annotated locations for XP_011540857.1

UniProtKB/TrEMBL

Q86T74

Conserved Domains (2) summary

smart00456
Location:53 → 85

WW; Domain with 2 conserved Trp (W) residues

cd00201
Location:1 → 25

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...