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    MRGPRX3 MAS related GPR family member X3 [ Homo sapiens (human) ]

    Gene ID: 117195, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MRGPRX3provided by HGNC
    Official Full Name
    MAS related GPR family member X3provided by HGNC
    Primary source
    HGNC:HGNC:17980
    See related
    Ensembl:ENSG00000179826 MIM:607229; AllianceGenome:HGNC:17980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPCR; MRGX3; SNSR1; SNSR2
    Summary
    This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See MRGPRX3 in Genome Data Viewer
    Location:
    11p15.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18120955..18138488)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18216477..18233987)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18142502..18160035)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 5 Neighboring gene serum amyloid A3, pseudogene Neighboring gene MAS related GPR family member X12, pseudogene Neighboring gene MAS related GPR family member X4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease. Franco R, et al. Prog Neurobiol, 2017 Feb-Mar. PMID 28189739
    2. GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib. Chen LY, et al. Acta Pharmacol Sin, 2022 Jun. PMID 34552215, Free PMC Article
    3. GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro. Schmid CD, et al. Biochem Biophys Res Commun, 2018 Feb 26. PMID 29408502
    4. Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype. Kaisho Y, et al. Biochem Biophys Res Commun, 2005 May 13. PMID 15809047
    5. Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs. Lembo PM, et al. Nat Neurosci, 2002 Mar. PMID 11850634

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib.
      Title: GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib.
    2. Our data demonstrate that GPR182 is an endothelial subtype-specific marker for human sinusoidal EC of the liver, spleen, lymph node and bone marrow. In addition, we provide evidence for GPR182-dependent downstream signaling via ERK and SRF pathways that may be involved in regulating endothelial subtype-specific sinusoidal differentiation and sinusoidal functions such as permeability.
      Title: GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro.
    3. Potential of GPCRs to modulate MAPK and mTOR pathways in different stages of the neurodegenerative disease.
      Title: Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease.
    4. overexpression of the human MrgX3 gene causes a disturbance of the normal cell-differentiation process
      Title: Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mas-related G-protein coupled receptor member X3
    Names
    G protein-coupled receptor MRGX3
    G protein-coupled receptor SNSR1
    G protein-coupled receptor SNSR2
    MAS-related GPR, member X3
    mas-related GPCR member X3
    sensory neuron-specific G-protein coupled receptor 1/2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370464.1 → NP_001357393.1  mas-related G-protein coupled receptor member X3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC090099
      Consensus CDS
      CCDS7830.1
      UniProtKB/Swiss-Prot
      B0M0L1, Q8TDE0, Q8TDE1, Q96LB0
      UniProtKB/TrEMBL
      W8W3E1
      Related
      ENSP00000481943.1, ENST00000621697.2
      Conserved Domains (1) summary
      cd15106
      Location:28 → 299
      7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_054031.4 → NP_473372.3  mas-related G-protein coupled receptor member X3

      See identical proteins and their annotated locations for NP_473372.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC090099, BC067292
      Consensus CDS
      CCDS7830.1
      UniProtKB/Swiss-Prot
      B0M0L1, Q8TDE0, Q8TDE1, Q96LB0
      UniProtKB/TrEMBL
      W8W3E1
      Related
      ENSP00000379571.2, ENST00000396275.2
      Conserved Domains (1) summary
      cd15106
      Location:28 → 299
      7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      18120955..18138488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      18216477..18233987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96LB0.2 GenPept UniProtKB/Swiss-Prot:Q96LB0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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