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    IL18BP interleukin 18 binding protein [ Homo sapiens (human) ]

    Gene ID: 10068, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IL18BPprovided by HGNC
    Official Full Name
    interleukin 18 binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:5987
    See related
    Ensembl:ENSG00000137496 MIM:604113; AllianceGenome:HGNC:5987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FVH; IL18BPa
    Summary
    The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
    Expression
    Broad expression in spleen (RPKM 11.4), appendix (RPKM 6.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IL18BP in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (71998909..72008200)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (71925824..71929835)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71709955..71713965)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene XNDC1N-ZNF705EP-ALG1L9P readthrough Neighboring gene XRCC1 N-terminal domain containing 1, N-terminal like Neighboring gene olfactory receptor family 7 subfamily E member 126 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71660091-71661028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71661029-71661964 Neighboring gene ring finger protein 121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5175 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5174 Neighboring gene uncharacterized LOC100128494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71725991-71726738 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:71728895-71730094 Neighboring gene Sharpr-MPRA regulatory region 3523 Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71751839-71752624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71752625-71753408 Neighboring gene uncharacterized LOC124902815

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Interleukin-18 binding protein regulates the apoptosis and necroptosis of fibroblast-like synoviocytes and chondrocytes in rheumatoid arthritis. Min HK, et al. Clin Exp Rheumatol, 2023 Nov. PMID 37083154
    2. Serum levels of interleukin-18-binding protein isoform a: Clinical association with inflammation and pulmonary hypertension in systemic sclerosis. Nakamura K, et al. J Dermatol, 2016 Aug. PMID 26777734
    3. Failure of interferon gamma to induce the anti-inflammatory interleukin 18 binding protein in familial hemophagocytosis. Nold-Petry CA, et al. PLoS One, 2010 Jan 13. PMID 20072626, Free PMC Article
    4. IL-18BP is decreased in osteoporotic women: Prevents Inflammasome mediated IL-18 activation and reduces Th17 differentiation. Mansoori MN, et al. Sci Rep, 2016 Sep 21. PMID 27649785, Free PMC Article
    5. A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors. Iannello A, et al. Cytokine, 2017 Feb. PMID 27863336

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interleukin-18 binding protein regulates the apoptosis and necroptosis of fibroblast-like synoviocytes and chondrocytes in rheumatoid arthritis.
      Title: Interleukin-18 binding protein regulates the apoptosis and necroptosis of fibroblast-like synoviocytes and chondrocytes in rheumatoid arthritis.
    2. Level of interleukin-18 binding protein is significantly different in patients with anaphylaxis than urticaria.
      Title: Level of interleukin-18 binding protein is significantly different in patients with anaphylaxis than urticaria.
    3. Interleukin-18 and IL-18BP in inflammatory dermatological diseases.
      Title: Interleukin-18 and IL-18BP in inflammatory dermatological diseases.
    4. Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case-control study.
      Title: Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case-control study.
    5. Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity.
      Title: Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity.
    6. Balance between Interleukin-18 and Interleukin-18 binding protein in auto-inflammatory diseases.
      Title: Balance between Interleukin-18 and Interleukin-18 binding protein in auto-inflammatory diseases.
    7. Interleukin-18 binding protein in infants and children hospitalized with pneumonia in low-resource settings.
      Title: Interleukin-18 binding protein in infants and children hospitalized with pneumonia in low-resource settings.
    8. IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis.
      Title: IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis.
    9. IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria.
      Title: IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria.
    10. IL-18 and IL-18 binding protein concentration in ovarian follicular fluid of women with unexplained infertility to PCOS during in vitro fertilization.
      Title: IL-18 and IL-18 binding protein concentration in ovarian follicular fluid of women with unexplained infertility to PCOS during in vitro fertilization.
    Submit: New GeneRIF Correction See all GeneRIFs (50)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Hepatitis, fulminant viral, susceptibility to
    MedGen: C5231406 OMIM: 618549 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables interleukin-18 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-18 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables receptor antagonist activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T-helper 1 type immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T-helper 1 type immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-18-binding protein
    Names
    MC51L-53L-54L homolog gene product
    tadekinig-alfa

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029021.2 RefSeqGene

      Range
      5002..8897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001039659.2 → NP_001034748.1  interleukin-18-binding protein isoform a precursor

      See identical proteins and their annotated locations for NP_001034748.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (E) differs in the 5' UTR compared to variant A. Variants A, E, F and G encode the same isoform (a, also known as IL-18BPa).
      Source sequence(s)
      AF110799, AP002490, AW295729, BX357194
      Consensus CDS
      CCDS8206.2
      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
      UniProtKB/TrEMBL
      Q9UNH2
      Related
      ENSP00000377308.4, ENST00000393705.8
      Conserved Domains (1) summary
      cl23951
      Location:79 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    2. NM_001039660.2 → NP_001034749.1  interleukin-18-binding protein isoform a precursor

      See identical proteins and their annotated locations for NP_001034749.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (F) differs in the 5' UTR compared to variant A. Variants A, E, F and G encode the same isoform (a, also known as IL-18BPa).
      Source sequence(s)
      AF110799, AP002490, AW295729, BX357194, CB154498
      Consensus CDS
      CCDS8206.2
      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
      UniProtKB/TrEMBL
      Q9UNH2
      Related
      ENSP00000377306.4, ENST00000393703.9
      Conserved Domains (1) summary
      cl23951
      Location:79 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    3. NM_001145055.1 → NP_001138527.1  interleukin-18-binding protein isoform b precursor

      See identical proteins and their annotated locations for NP_001138527.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (H) lacks two internal exons in the 3' coding region compared to variant A, which results in a frame-shift and a shorter isoform (b, also known as IL-18BPb) with a distinct C-terminus compared to isoform a. This isoform lacks the ability to bind IL-18 (PMID:10655506).
      Source sequence(s)
      AF110800, AW295729
      Consensus CDS
      CCDS44666.1
      Related
      ENSP00000377310.4, ENST00000393707.4

    4. NM_001145057.1 → NP_001138529.1  interleukin-18-binding protein isoform a precursor

      See identical proteins and their annotated locations for NP_001138529.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (G) differs in the 5' UTR compared to variant A. Variants A, E, F and G encode the same isoform (a, also known as IL-18BPa).
      Source sequence(s)
      AF122906, AW295729, BM819966
      Consensus CDS
      CCDS8206.2
      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
      UniProtKB/TrEMBL
      Q9UNH2
      Conserved Domains (1) summary
      cl23951
      Location:79 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    5. NM_005699.3 → NP_005690.2  interleukin-18-binding protein isoform c precursor

      See identical proteins and their annotated locations for NP_005690.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (C) is alternatively spliced in the 3' coding region compared to variant A. This results in a frame-shift, and a longer isoform (c, also known as IL-18BPc) with a distinct C-terminus compared to isoform a. This isoform retains the ability to bind IL-18 (PMID:10655506).
      Source sequence(s)
      AF110799, AF110801, AL698586
      Consensus CDS
      CCDS8207.2
      UniProtKB/TrEMBL
      A0A024R5M6, G3V1C5
      Related
      ENSP00000434717.1, ENST00000497194.6
      Conserved Domains (1) summary
      cl23951
      Location:79 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    6. NM_173042.2 → NP_766630.2  interleukin-18-binding protein isoform a precursor

      See identical proteins and their annotated locations for NP_766630.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) encodes the predominant isoform (a, also known as IL-18BPa), which shows the highest affinity for binding IL-18 (PMID:10655506). Variants A, E, F and G encode the same isoform.
      Source sequence(s)
      AF110799, AF110801, AW295729
      Consensus CDS
      CCDS8206.2
      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
      UniProtKB/TrEMBL
      Q9UNH2
      Related
      ENSP00000384212.1, ENST00000404792.5
      Conserved Domains (1) summary
      cl23951
      Location:79 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    7. NM_173044.3 → NP_766632.2  interleukin-18-binding protein isoform d precursor

      See identical proteins and their annotated locations for NP_766632.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (D) differs in the 5' UTR and uses an alternate donor splice site at the penultimate coding exon compared to variant A. This results in a frame-shift and a shorter isoform (d, also known as IL-18BPd) with a distinct C-terminus compared to isoform a. This isoform lacks the ability to bind IL-18 (PMID:10655506).
      Source sequence(s)
      AF215907, AP002490, CB154498
      Consensus CDS
      CCDS8205.1
      Related
      ENSP00000480621.1, ENST00000620017.4
      Conserved Domains (1) summary
      cl23951
      Location:79 → 122
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      71998909..72008200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426203.1 → XP_047282159.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
      Related
      ENSP00000513973.1, ENST00000698837.1

    2. XM_047426206.1 → XP_047282162.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
      Related
      ENSP00000513975.1, ENST00000698839.1

    3. XM_047426207.1 → XP_047282163.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

    4. XM_017017059.2 → XP_016872548.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
      UniProtKB/TrEMBL
      Q9UNH2
      Conserved Domains (1) summary
      cl23951
      Location:79 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    5. XM_017017061.3 → XP_016872550.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
      UniProtKB/TrEMBL
      Q9UNH2
      Conserved Domains (1) summary
      cl23951
      Location:79 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    6. XM_047426205.1 → XP_047282161.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
      Related
      ENSP00000338723.5, ENST00000337131.9

    7. XM_047426204.1 → XP_047282160.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

    8. XM_024448304.2 → XP_024304072.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
      UniProtKB/TrEMBL
      Q9UNH2
      Conserved Domains (1) summary
      cl23951
      Location:79 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    9. XM_047426208.1 → XP_047282164.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

    10. XM_017017063.2 → XP_016872552.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
      UniProtKB/TrEMBL
      Q9UNH2
      Conserved Domains (1) summary
      cl23951
      Location:79 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    11. XM_024448303.2 → XP_024304071.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
      UniProtKB/TrEMBL
      Q9UNH2
      Conserved Domains (1) summary
      cl23951
      Location:79 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      71925824..71929835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367385.1 → XP_054223360.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

    2. XM_054367386.1 → XP_054223361.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

    3. XM_054367387.1 → XP_054223362.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

    4. XM_054367390.1 → XP_054223365.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

    5. XM_054367392.1 → XP_054223367.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

    6. XM_054367388.1 → XP_054223363.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

    7. XM_054367394.1 → XP_054223369.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

    8. XM_054367391.1 → XP_054223366.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

    9. XM_054367393.1 → XP_054223368.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

    10. XM_054367389.1 → XP_054223364.1  interleukin-18-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173043.1: Suppressed sequence

      Description
      NM_173043.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95998.2 GenPept UniProtKB/Swiss-Prot:O95998

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