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    CADPS2 calcium dependent secretion activator 2 [ Homo sapiens (human) ]

    Gene ID: 93664, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CADPS2provided by HGNC
    Official Full Name
    calcium dependent secretion activator 2provided by HGNC
    Primary source
    HGNC:HGNC:16018
    See related
    Ensembl:ENSG00000081803 MIM:609978; AllianceGenome:HGNC:16018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAPS2
    Summary
    This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
    Expression
    Ubiquitous expression in kidney (RPKM 9.9), brain (RPKM 7.6) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CADPS2 in Genome Data Viewer
    Location:
    7q31.32
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (122318411..122886460, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (123634402..124203026, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (121958465..122526514, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 37 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:121924115-121924720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:121951480-121951992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:121951993-121952505 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:121955253-121955783 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:121956930-121957784 Neighboring gene VISTA enhancer hs1809 Neighboring gene FEZF1 antisense RNA 1 Neighboring gene FEZ family zinc finger 1 Neighboring gene NANOG hESC enhancer GRCh37_chr7:122088873-122089630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:122167222-122167722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:122167723-122168223 Neighboring gene uncharacterized LOC105375481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26564 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:122319235-122319791 Neighboring gene uncharacterized LOC124901739 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:122332441-122332940 Neighboring gene uncharacterized LOC124901738 Neighboring gene ribosomal protein S26 pseudogene 31 Neighboring gene ring finger protein 133 Neighboring gene ring finger protein 148 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:122458991-122459843 Neighboring gene RELA proto-oncogene, NF-kB subunit pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18581 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:122553388-122553898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:122553899-122554408 Neighboring gene uncharacterized LOC105375482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:122572022-122572522 Neighboring gene NANOG hESC enhancer GRCh37_chr7:122627466-122627971 Neighboring gene taste 2 receptor member 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Blood CADPS2ΔExon3 expression is associated with intelligence and memory in healthy adults. Hattori K, et al. Biol Psychol, 2012 Jan. PMID 22001167
    2. Maternally inherited genetic variants of CADPS2 are present in autism spectrum disorders and intellectual disability patients. Bonora E, et al. EMBO Mol Med, 2014 Jun. PMID 24737869, Free PMC Article
    3. Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. Sadakata T, et al. J Clin Invest, 2007 Apr. PMID 17380209, Free PMC Article
    4. Submicroscopic deletion in 7q31 encompassing CADPS2 and TSPAN12 in a child with autism spectrum disorder and PHPV. Okamoto N, et al. Am J Med Genet A, 2011 Jul. PMID 21626674
    5. Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level. Zhang K, et al. World J Biol Psychiatry, 2019 Jul. PMID 28971736, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior.
      Title: Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior.
    2. The top SNP rs2049161 involved gene DLGAP1 and the top gene CADPS2 in the gene-based analysis resulted in much literature evidence of associations with psychiatric disorders. Gene expression and network analysis showed their contribution to cognition function.
      Title: Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level.
    3. These results indicate that LRRK2 and alpha-synuclein participate in the dysregulation of CADPS2 by altering transcription and support the hypothesis that synaptic dysfunctions, through different mechanisms, might contribute to the neuronal defects of diseases such as Parkinson's disease.
      Title: CADPS2 gene expression is oppositely regulated by LRRK2 and alpha-synuclein.
    4. Mutation screening of 187 patients with autism spectrum disorders and 36 with intellectual disability identified a missense change of maternal origin disrupting CADPS2/D2DR interaction.
      Title: Maternally inherited genetic variants of CADPS2 are present in autism spectrum disorders and intellectual disability patients.
    5. This study suggested that CADPS2DeltaExon3 affects intelligence and memory in the non-clinical population.
      Title: Blood CADPS2ΔExon3 expression is associated with intelligence and memory in healthy adults.
    6. We speculate that haploinsufficiency of CADPS2 contributes to ASDs.
      Title: Submicroscopic deletion in 7q31 encompassing CADPS2 and TSPAN12 in a child with autism spectrum disorder and PHPV.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Voxelwise genome-wide association study (vGWAS).
    9. Genetic disturbance in CADPS2-mediated neurotrophin release contributes to autism susceptibility.
      Title: Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients.
    10. CAPS proteins are involved in optimizing vesicular monoamine uptake and storage mediated by VMAT1 and VMAT2
      Title: Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-07-10)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-07-10)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    Voxelwise genome-wide association study (vGWAS).
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40851, KIAA1591

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dense core granule exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcium-dependent secretion activator 2
    Names
    CAPS-2
    Ca++-dependent secretion activator 2
    Ca2+ dependent secretion activator 2
    Ca2+-dependent activator protein for secretion 2
    calcium-dependent activator protein for secretion 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016215.2 RefSeqGene

      Range
      5300..573349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001009571.4 → NP_001009571.2  calcium-dependent secretion activator 2 isoform b

      See identical proteins and their annotated locations for NP_001009571.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three alternate in-frame exons and includes an alternate in-frame exon, compared to variant 3. The resulting isoform (b) differs in four regions and is shorter compared to isoform c.
      Source sequence(s)
      AB046811, AC015983, AF401638, BX110721, DA248542
      Consensus CDS
      CCDS47691.1
      UniProtKB/TrEMBL
      X5DNG0, X5DQT2
      Related
      ENSP00000400401.2, ENST00000412584.6
      Conserved Domains (4) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:489 → 588
      PH; PH domain
      pfam06292
      Location:798 → 888
      DUF1041; Domain of Unknown Function (DUF1041)

    2. NM_001167940.2 → NP_001161412.1  calcium-dependent secretion activator 2 isoform c

      See identical proteins and their annotated locations for NP_001161412.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AC015983, AF401638, BC144279, BX110721, DA248542
      UniProtKB/TrEMBL
      B7ZM57, X5DQT2
      Related
      ENSP00000325581.8, ENST00000313070.11
      Conserved Domains (4) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:489 → 588
      PH; PH domain
      pfam06292
      Location:801 → 898
      DUF1041; Domain of Unknown Function (DUF1041)

    3. NM_001363389.2 → NP_001350318.1  calcium-dependent secretion activator 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AB046811, AC006463, AC015983, BP376175, BX110721, DA060101, DA210803, DA248542, KJ534803
      UniProtKB/TrEMBL
      X5D8W6
      Conserved Domains (3) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:801 → 901
      DUF1041; Domain of Unknown Function (DUF1041)

    4. NM_001363390.2 → NP_001350319.1  calcium-dependent secretion activator 2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC006463, AC015983, AK054853, BX110721, DA210803, DA248542, KJ534803
      UniProtKB/TrEMBL
      X5D8W6
      Conserved Domains (3) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:801 → 901
      DUF1041; Domain of Unknown Function (DUF1041)

    5. NM_001363391.2 → NP_001350320.1  calcium-dependent secretion activator 2 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC006463, AC015983, AK054853, BP378689, BX110721, DA041479, DA210803, DA248542, KJ534803
      UniProtKB/TrEMBL
      X5D8W6
      Conserved Domains (3) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:798 → 898
      DUF1041; Domain of Unknown Function (DUF1041)

    6. NM_001363392.2 → NP_001350321.1  calcium-dependent secretion activator 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AB046811, AC006463, AC015983, BP376175, BX110721, DA210803, DA248542, DT220064, KJ534803
      UniProtKB/TrEMBL
      X5D8W6
      Conserved Domains (3) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:801 → 901
      DUF1041; Domain of Unknown Function (DUF1041)

    7. NM_001363393.2 → NP_001350322.1  calcium-dependent secretion activator 2 isoform h

      Status: REVIEWED

      Source sequence(s)
      AB046811, AC006463, AC015983, BX110721, DA248542, KJ534803, KJ534804
      UniProtKB/TrEMBL
      X5D2D9, X5D8W6
      Conserved Domains (3) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:801 → 901
      DUF1041; Domain of Unknown Function (DUF1041)

    8. NM_001363394.2 → NP_001350323.1  calcium-dependent secretion activator 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AB046811, AC004594, AC006463, AC015983, BX110721, DA248542, KJ534803
      UniProtKB/TrEMBL
      X5D8X0, X5DQT2
      Conserved Domains (3) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:801 → 898
      DUF1041; Domain of Unknown Function (DUF1041)

    9. NM_001363395.2 → NP_001350324.1  calcium-dependent secretion activator 2 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC004594, AC004838, AC006009, AC006463, AC015983, AC091438
      UniProtKB/TrEMBL
      X5DQT2
      Conserved Domains (3) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:798 → 895
      DUF1041; Domain of Unknown Function (DUF1041)

    10. NM_001363396.2 → NP_001350325.1  calcium-dependent secretion activator 2 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC006463, AC015983, AK054853, BX110721, DA248542, KJ534798, KJ534803
      UniProtKB/TrEMBL
      X5D8W6
      Conserved Domains (3) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:801 → 894
      DUF1041; Domain of Unknown Function (DUF1041)

    11. NM_001363397.2 → NP_001350326.1  calcium-dependent secretion activator 2 isoform l

      Status: REVIEWED

      Source sequence(s)
      AB046811, AC004594, AC006463, AC015983, BX110721, DA248542, KJ534802, KJ534803
      UniProtKB/TrEMBL
      X5DQT2
      Conserved Domains (3) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:801 → 891
      DUF1041; Domain of Unknown Function (DUF1041)

    12. NM_001363398.2 → NP_001350327.1  calcium-dependent secretion activator 2 isoform m

      Status: REVIEWED

      Source sequence(s)
      AC015983, AK054853, BX110721, DA248542, KJ534805
      UniProtKB/TrEMBL
      X5D7B2, X5DQT2
      Conserved Domains (3) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:798 → 888
      DUF1041; Domain of Unknown Function (DUF1041)

    13. NM_001363399.2 → NP_001350328.1  calcium-dependent secretion activator 2 isoform n

      Status: REVIEWED

      Source sequence(s)
      AC004594, AC004838, AC006009, AC006463, AC015983, AC091438
      UniProtKB/TrEMBL
      F8W8P5
      Conserved Domains (3) summary
      smart00239
      Location:205 → 287
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:320 → 439
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:640 → 740
      DUF1041; Domain of Unknown Function (DUF1041)

    14. NM_001363400.2 → NP_001350329.1  calcium-dependent secretion activator 2 isoform o

      Status: REVIEWED

      Source sequence(s)
      AC004594, AC004838, AC006009, AC006463, AC015983, AC091438
      UniProtKB/TrEMBL
      F8W8P5
      Conserved Domains (3) summary
      smart00239
      Location:205 → 287
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:320 → 439
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:640 → 740
      DUF1041; Domain of Unknown Function (DUF1041)

    15. NM_017954.11 → NP_060424.9  calcium-dependent secretion activator 2 isoform a

      See identical proteins and their annotated locations for NP_060424.9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon and includes an alternate in-frame exon, compared to variant 3. The resulting isoform (a) differs in two regions and is shorter compared to isoform c.
      Source sequence(s)
      AB046811, AC015983, AY264289, BC144278, BX110721, DA248542
      Consensus CDS
      CCDS55158.1
      UniProtKB/Swiss-Prot
      A4D0X3, B7ZM56, Q658Q2, Q7Z5T7, Q86UW7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8
      UniProtKB/TrEMBL
      X5D8W6
      Related
      ENSP00000398481.2, ENST00000449022.7
      Conserved Domains (4) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:489 → 588
      PH; PH domain
      pfam06292
      Location:801 → 894
      DUF1041; Domain of Unknown Function (DUF1041)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      122318411..122886460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421032.1 → XP_047276988.1  calcium-dependent secretion activator 2 isoform X8

    2. XM_017012794.3 → XP_016868283.1  calcium-dependent secretion activator 2 isoform X6

      UniProtKB/TrEMBL
      X5DQT2

    3. XM_005250702.6 → XP_005250759.1  calcium-dependent secretion activator 2 isoform X7

      UniProtKB/TrEMBL
      X5D8W6
      Conserved Domains (4) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:489 → 588
      PH; PH domain
      pfam06292
      Location:798 → 891
      DUF1041; Domain of Unknown Function (DUF1041)

    4. XM_047421031.1 → XP_047276987.1  calcium-dependent secretion activator 2 isoform X4

    5. XM_047421033.1 → XP_047276989.1  calcium-dependent secretion activator 2 isoform X10

    6. XM_005250706.6 → XP_005250763.1  calcium-dependent secretion activator 2 isoform X11

      UniProtKB/TrEMBL
      X5D8W6
      Conserved Domains (4) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:489 → 588
      PH; PH domain
      pfam06292
      Location:798 → 898
      DUF1041; Domain of Unknown Function (DUF1041)

    7. XM_005250697.6 → XP_005250754.1  calcium-dependent secretion activator 2 isoform X1

      UniProtKB/TrEMBL
      X5D8W6
      Conserved Domains (4) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:489 → 588
      PH; PH domain
      pfam06292
      Location:798 → 898
      DUF1041; Domain of Unknown Function (DUF1041)

    8. XM_005250707.6 → XP_005250764.1  calcium-dependent secretion activator 2 isoform X12

      UniProtKB/TrEMBL
      X5DQT2
      Conserved Domains (4) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:489 → 588
      PH; PH domain
      pfam06292
      Location:801 → 891
      DUF1041; Domain of Unknown Function (DUF1041)

    9. XM_005250701.6 → XP_005250758.1  calcium-dependent secretion activator 2 isoform X5

      UniProtKB/TrEMBL
      X5DQT2
      Conserved Domains (4) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:489 → 588
      PH; PH domain
      pfam06292
      Location:801 → 891
      DUF1041; Domain of Unknown Function (DUF1041)

    10. XM_005250699.6 → XP_005250756.1  calcium-dependent secretion activator 2 isoform X3

      UniProtKB/TrEMBL
      X5D8W6
      Conserved Domains (4) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:489 → 588
      PH; PH domain
      pfam06292
      Location:801 → 894
      DUF1041; Domain of Unknown Function (DUF1041)

    11. XM_005250704.6 → XP_005250761.1  calcium-dependent secretion activator 2 isoform X9

      UniProtKB/TrEMBL
      X5DQT2
      Conserved Domains (4) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:489 → 588
      PH; PH domain
      pfam06292
      Location:801 → 898
      DUF1041; Domain of Unknown Function (DUF1041)

    12. XM_005250696.6 → XP_005250753.1  calcium-dependent secretion activator 2 isoform X2

      UniProtKB/TrEMBL
      X5DQT2
      Conserved Domains (4) summary
      smart00239
      Location:366 → 448
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:481 → 600
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:489 → 588
      PH; PH domain
      pfam06292
      Location:801 → 898
      DUF1041; Domain of Unknown Function (DUF1041)

    13. XM_017012796.3 → XP_016868285.1  calcium-dependent secretion activator 2 isoform X13

      UniProtKB/TrEMBL
      F8W8P5

    14. XM_047421034.1 → XP_047276990.1  calcium-dependent secretion activator 2 isoform X14

      Related
      ENSP00000380833.4, ENST00000397721.4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      123634402..124203026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359340.1 → XP_054215315.1  calcium-dependent secretion activator 2 isoform X8

    2. XM_054359338.1 → XP_054215313.1  calcium-dependent secretion activator 2 isoform X6

    3. XM_054359339.1 → XP_054215314.1  calcium-dependent secretion activator 2 isoform X7

    4. XM_054359336.1 → XP_054215311.1  calcium-dependent secretion activator 2 isoform X4

    5. XM_054359342.1 → XP_054215317.1  calcium-dependent secretion activator 2 isoform X10

    6. XM_054359343.1 → XP_054215318.1  calcium-dependent secretion activator 2 isoform X11

    7. XM_054359333.1 → XP_054215308.1  calcium-dependent secretion activator 2 isoform X1

    8. XM_054359344.1 → XP_054215319.1  calcium-dependent secretion activator 2 isoform X12

    9. XM_054359337.1 → XP_054215312.1  calcium-dependent secretion activator 2 isoform X5

    10. XM_054359335.1 → XP_054215310.1  calcium-dependent secretion activator 2 isoform X3

    11. XM_054359341.1 → XP_054215316.1  calcium-dependent secretion activator 2 isoform X9

    12. XM_054359334.1 → XP_054215309.1  calcium-dependent secretion activator 2 isoform X2

    13. XM_054359345.1 → XP_054215320.1  calcium-dependent secretion activator 2 isoform X13

    14. XM_054359346.1 → XP_054215321.1  calcium-dependent secretion activator 2 isoform X14

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86UW7.2 GenPept UniProtKB/Swiss-Prot:Q86UW7

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