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    ELOA2 elongin A2 [ Homo sapiens (human) ]

    Gene ID: 51224, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ELOA2provided by HGNC
    Official Full Name
    elongin A2provided by HGNC
    Primary source
    HGNC:HGNC:30771
    See related
    Ensembl:ENSG00000206181 MIM:609522; AllianceGenome:HGNC:30771
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HsT832; TCEB3B; TCEB3L
    Summary
    This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]
    Orthologs
    all
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    Genomic context

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    Location:
    18q21.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (47032527..47035621, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (47222798..47225892, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (44558898..44561992, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44546997-44547496 Neighboring gene elongin A3 family member D, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44552405-44553168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44553169-44553932 Neighboring gene MPRA-validated peak3137 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:44554945-44555448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:44555449-44555951 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:44555952-44556454 Neighboring gene elongin A3 family member B, pseudogene Neighboring gene uncharacterized LOC105372098 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:44626710-44626922 Neighboring gene haloacid dehalogenase like hydrolase domain containing 2 Neighboring gene small ubiquitin-related modifier 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis. Aso T, et al. J Biol Chem, 2000 Mar 3. PMID 10692460
    2. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. Aso T, et al. Science, 1995 Sep 8. PMID 7660129
    3. RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. Bradsher JN, et al. J Biol Chem, 1993 Dec 5. PMID 8244996
    4. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Anders L, et al. Cancer Cell, 2011 Nov 15. PMID 22094256, Free PMC Article
    5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. Lu L, et al. J Biol Chem, 2013 Dec 13. PMID 24163370, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC119351

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription elongation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of elongin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    elongin-A2
    Names
    RNA polymerase II transcription factor SIII subunit A2
    transcription elongation factor (SIII) elongin A2 elongin A2
    transcription elongation factor B polypeptide 3B
    transcription elongation factor B subunit 3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050760.1 RefSeqGene

      Range
      4997..8091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_016427.3 → NP_057511.2  elongin-A2

      See identical proteins and their annotated locations for NP_057511.2

      Status: REVIEWED

      Source sequence(s)
      AB030834, AC012254, BC036022
      Consensus CDS
      CCDS11932.1
      UniProtKB/Swiss-Prot
      Q8IYF1, Q9P2V9
      UniProtKB/TrEMBL
      B2RC86
      Related
      ENSP00000331302.4, ENST00000332567.6
      Conserved Domains (2) summary
      smart00509
      Location:8 → 77
      TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
      pfam06881
      Location:544 → 642
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      47032527..47035621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      47222798..47225892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IYF1.2 GenPept UniProtKB/Swiss-Prot:Q8IYF1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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