BAG5 BAG cochaperone 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BAG5provided by HGNC
Official Full Name: BAG cochaperone 5provided by HGNC
Primary source: HGNC:HGNC:941
See related: Ensembl:ENSG00000166170 MIM:603885; AllianceGenome:HGNC:941
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BAG-5; CMD2F
Summary: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 41.2), thyroid (RPKM 15.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q32.33

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (103556551..103562657, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (97792597..97798702, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (104022888..104028994, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch.
Title: Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch.
Implication of BAG5 downregulation in metabolic reprogramming of cisplatin-resistant ovarian cancer cells via mTORC2 signaling pathway.
Title: Implication of BAG5 downregulation in metabolic reprogramming of cisplatin-resistant ovarian cancer cells via mTORC2 signaling pathway.
Bcl-2-associated athanogene 5 overexpression attenuates catecholamine-induced vascular endothelial cell apoptosis.
Title: Bcl-2-associated athanogene 5 overexpression attenuates catecholamine-induced vascular endothelial cell apoptosis.
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability.
Title: PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability.
Circ_0008305-mediated miR-660/BAG5 axis contributes to hepatocellular carcinoma tumorigenesis.
Title: Circ_0008305-mediated miR-660/BAG5 axis contributes to hepatocellular carcinoma tumorigenesis.
Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation.
Title: Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation.
Stress-induced p53 drives BAG5 cochaperone expression to control alpha-synuclein aggregation in Parkinson's disease.
Title: Stress-induced p53 drives BAG5 cochaperone expression to control α-synuclein aggregation in Parkinson's disease.
miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1.
Title: miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1.
Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death.
Title: Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death.
BAG5 was found as a expression variability marker in an 8-cell human embryo.
Title: Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Cardiomyopathy, dilated, 2F MedGen: C5676917 OMIM: 619747 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14S1221 (e-PCR)
- UniSTS:2901

D15S1477 (e-PCR)
- UniSTS:474482

RH48083 (e-PCR)
- UniSTS:22146

RH69364 (e-PCR)
- UniSTS:21179

BAG5_3934 (e-PCR)
- UniSTS:462050

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein refolding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein folding	TAS Traceable Author Statement more info	PubMed
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of inclusion body assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inclusion body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ubiquitin-protein transferase activity	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in inclusion body	IDA Inferred from Direct Assay more info	PubMed
part_of junctional membrane complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BAG family molecular chaperone regulator 5

Names: BCL2 associated athanogene 5; bcl-2-associated athanogene 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015048.3 → NP_001015048.1 BAG family molecular chaperone regulator 5

See identical proteins and their annotated locations for NP_001015048.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AL139300, BF941752, CA424706

Consensus CDS

CCDS9982.1

UniProtKB/Swiss-Prot

O94950, Q86W59, Q9UL15

UniProtKB/TrEMBL

A0A024R6M6, A8K5J7

Related

ENSP00000299204.4, ENST00000299204.6

Conserved Domains (1) summary

smart00264
Location:365 → 442

BAG; BAG domains, present in regulator of Hsp70 proteins
NM_001015049.5 → NP_001015049.2 BAG family molecular chaperone regulator 5

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AL139300

Consensus CDS

CCDS9982.1

UniProtKB/Swiss-Prot

O94950, Q86W59, Q9UL15

UniProtKB/TrEMBL

A0A024R6M6, A8K5J7

Related

ENSP00000338814.5, ENST00000337322.5

Conserved Domains (1) summary

smart00264
Location:365 → 442

BAG; BAG domains, present in regulator of Hsp70 proteins
NM_004873.4 → NP_004864.1 BAG family molecular chaperone regulator 5

See identical proteins and their annotated locations for NP_004864.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AF095195, AL139300, CA424706, DB022769

Consensus CDS

CCDS9982.1

UniProtKB/Swiss-Prot

O94950, Q86W59, Q9UL15

UniProtKB/TrEMBL

A0A024R6M6, A8K5J7

Related

ENSP00000391713.2, ENST00000445922.2

Conserved Domains (1) summary

smart00264
Location:365 → 442

BAG; BAG domains, present in regulator of Hsp70 proteins