STAT5A signal transducer and activator of transcription 5A [Homo sapiens (human)] - Gene

Summary

Official Symbol: STAT5Aprovided by HGNC
Official Full Name: signal transducer and activator of transcription 5Aprovided by HGNC
Primary source: HGNC:HGNC:11366
See related: Ensembl:ENSG00000126561 MIM:601511; AllianceGenome:HGNC:11366
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MGF; STAT5
Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Expression: Broad expression in fat (RPKM 52.7), bone marrow (RPKM 20.9) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.2

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (42287439..42311943)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (43143926..43168430)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (40439457..40463961)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility.
Title: PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility.
IDH2/R140Q mutation confers cytokine-independent proliferation of TF-1 cells by activating constitutive STAT3/5 phosphorylation.
Title: IDH2/R140Q mutation confers cytokine-independent proliferation of TF-1 cells by activating constitutive STAT3/5 phosphorylation.
Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
Title: Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
STAT5 is essential for inducing the suppressive subset and attenuate cytotoxicity of Vdelta2[+] T cells in acute myeloid leukemia.
Title: STAT5 is essential for inducing the suppressive subset and attenuate cytotoxicity of Vδ2(+) T cells in acute myeloid leukemia.
Abnormal M1 polarization of placental macrophage induced by IL-15/STAT5 activation in VVC may lead to adverse pregnancy outcomes.
Title: Abnormal M1 polarization of placental macrophage induced by IL-15/STAT5 activation in VVC may lead to adverse pregnancy outcomes.
A novel EGFR variant EGFRx maintains glioblastoma stem cells through STAT5.
Title: A novel EGFR variant EGFRx maintains glioblastoma stem cells through STAT5.
Dual inhibition of STAT3 and STAT5 may overcome imatinib resistance in chronic myeloid leukemia.
Title: Dual inhibition of STAT3 and STAT5 may overcome imatinib resistance in chronic myeloid leukemia.
Stat5 inhibits NLRP3-mediated pyroptosis to enhance chemoresistance of breast cancer cells via promoting miR-182 transcription.
Title: Stat5 inhibits NLRP3-mediated pyroptosis to enhance chemoresistance of breast cancer cells via promoting miR-182 transcription.
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation.
Title: Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of T(H)9 cells to promote allergic inflammation.
STAT5A modulates gastric cancer progression via upregulation of CD44.
Title: STAT5A modulates gastric cancer progression via upregulation of CD44.

Submit: New GeneRIF Correction See all GeneRIFs (304)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	CD4 ligation with HIV gp120 inhibits T cell receptor-induced tyrosine phosphorylation and expression of STAT5 by blocking activation and expression of JAK3	PubMed
capsid	gag	Silencing C-terminally truncated STAT5 expression by siRNA enhances HIV-1 RNA and p24 Gag expression in chronically HIV-infected U1 cell line	PubMed
	gag	STAT5 binds to the HIV-1 LTR during HIV infection, activating LTR transcription and leading to the upregulation of HIV-1 p24 Capsid production and an increase in the number of p24+ cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STAT5A_260 (e-PCR)
- UniSTS:277774

RH12579 (e-PCR)
- UniSTS:68921

RH122165 (e-PCR)
- UniSTS:134725

PMC262552P1 (e-PCR)
- UniSTS:272316

RH71461 (e-PCR)
- UniSTS:68570

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	NAS Non-traceable Author Statement more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in eosinophil differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-15-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-2-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-3-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-4-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-5-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-7-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-9-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T-helper 17 cell lineage commitment	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within reelin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of multicellular organism growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_positive_effect taurine metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	NAS Non-traceable Author Statement more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IC Inferred by Curator more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: signal transducer and activator of transcription 5A

Names: epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001288718.2 → NP_001275647.1 signal transducer and activator of transcription 5A isoform 1

See identical proteins and their annotated locations for NP_001275647.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 2 encode the same isoform.

Source sequence(s)

AB208972, AK291650, BC027036, L41142

Consensus CDS

CCDS11424.1

UniProtKB/Swiss-Prot

P42229, Q1KLZ6

UniProtKB/TrEMBL

A0A384N5W4, A0A7I2YQY3

Related

ENSP00000468749.1, ENST00000590949.6

Conserved Domains (4) summary

cd10421
Location:573 → 712

SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins

pfam01017
Location:141 → 330

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:332 → 582

STAT_bind; STAT protein, DNA binding domain

pfam02865
Location:2 → 124

STAT_int; STAT protein, protein interaction domain
NM_001288719.2 → NP_001275648.1 signal transducer and activator of transcription 5A isoform 2

See identical proteins and their annotated locations for NP_001275648.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame coding exon in the 5' region compared to variant 1. The resulting shorter isoform (2) lacks an internal protein segment compared to isoform 1.

Source sequence(s)

AB208972, BC027036, DQ471288

Consensus CDS

CCDS74067.1

UniProtKB/TrEMBL

A0A7I2YQY3

Related

ENSP00000443107.1, ENST00000546010.6

Conserved Domains (4) summary

cd10421
Location:543 → 682

SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins

cd16855
Location:109 → 300

STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cd16849
Location:302 → 459

STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

pfam02865
Location:4 → 95

STAT_int; STAT protein, protein interaction domain
NM_001288720.2 → NP_001275649.1 signal transducer and activator of transcription 5A isoform 3

See identical proteins and their annotated locations for NP_001275649.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an in-frame coding exon in the 3' region compared to variant 1. The resulting shorter isoform (3) lacks an internal protein segment compared to isoform 1.

Source sequence(s)

AB208972, AK291650, BC027036

Consensus CDS

CCDS74066.1

UniProtKB/TrEMBL

K7EK35, Q59GY7

Related

ENSP00000465437.1, ENST00000588868.5

Conserved Domains (4) summary

cd10421
Location:542 → 681

SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins

cd16855
Location:139 → 330

STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cl28920
Location:332 → 460

STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)

pfam02865
Location:4 → 124

STAT_int; STAT protein, protein interaction domain
NM_001411103.1 → NP_001398032.1 signal transducer and activator of transcription 5A isoform 4

Status: REVIEWED

Source sequence(s)

AC087691, AC099811

Consensus CDS

CCDS92308.1

UniProtKB/TrEMBL

A0A7I2YQF1

Related

ENSP00000503484.1, ENST00000676631.1
NM_003152.4 → NP_003143.2 signal transducer and activator of transcription 5A isoform 1

See identical proteins and their annotated locations for NP_003143.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AB208972, AK291650, BC027036, L41142, U43185

Consensus CDS

CCDS11424.1

UniProtKB/Swiss-Prot

P42229, Q1KLZ6

UniProtKB/TrEMBL

A0A384N5W4, A0A7I2YQY3

Related

ENSP00000341208.4, ENST00000345506.8

Conserved Domains (4) summary

cd10421
Location:573 → 712

SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins

pfam01017
Location:141 → 330

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:332 → 582

STAT_bind; STAT protein, DNA binding domain

pfam02865
Location:2 → 124

STAT_int; STAT protein, protein interaction domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

42287439..42311943

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047436590.1 → XP_047292546.1 signal transducer and activator of transcription 5A isoform X2
XM_047436589.1 → XP_047292545.1 signal transducer and activator of transcription 5A isoform X1

UniProtKB/Swiss-Prot

P42229, Q1KLZ6

UniProtKB/TrEMBL

A0A384N5W4
XM_047436591.1 → XP_047292547.1 signal transducer and activator of transcription 5A isoform X3
XM_047436588.1 → XP_047292544.1 signal transducer and activator of transcription 5A isoform X1

UniProtKB/Swiss-Prot

P42229, Q1KLZ6

UniProtKB/TrEMBL

A0A384N5W4

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

43143926..43168430

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054316996.1 → XP_054172971.1 signal transducer and activator of transcription 5A isoform X2
XM_054316995.1 → XP_054172970.1 signal transducer and activator of transcription 5A isoform X1

UniProtKB/Swiss-Prot

P42229, Q1KLZ6

UniProtKB/TrEMBL

A0A384N5W4
XM_054316997.1 → XP_054172972.1 signal transducer and activator of transcription 5A isoform X3
XM_054316994.1 → XP_054172969.1 signal transducer and activator of transcription 5A isoform X1

UniProtKB/Swiss-Prot

P42229, Q1KLZ6

UniProtKB/TrEMBL

A0A384N5W4