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    TLR8 toll like receptor 8 [ Bos taurus (cattle) ]

    Gene ID: 532262, updated on 6-Jun-2024

    Summary

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    Gene symbol
    TLR8
    Gene description
    toll like receptor 8
    See related
    Ensembl:ENSBTAG00000031020
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TLR8 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (130727684..130745770, complement)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104970637 Neighboring gene thymosin beta 4 X-linked Neighboring gene toll like receptor 7 Neighboring gene phosphoribosyl pyrophosphate synthetase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of TLR8 mediated signaling promotes BCG induced apoptosis in THP-1 cells. Tang J, et al. Microb Pathog, 2016 Apr. PMID 26657720
    2. Multiple molecular regions confer intracellular localization of bovine Toll-like receptor 8. Zhu J, et al. Mol Immunol, 2009 Feb. PMID 19019441
    3. Characterization of bovine Toll-like receptor 8: ligand specificity, signaling essential sites and dimerization. Zhu J, et al. Mol Immunol, 2009 Feb. PMID 18995910
    4. TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1. Kornuta CA, et al. Virology, 2022 Jan. PMID 34896902
    5. Toll-like receptors 3, 7 and 8 are upregulated in the placental caruncle and fetal spleen of Neospora caninum experimentally infected cattle. Marin MS, et al. Vet Parasitol, 2017 Mar 15. PMID 28288766

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1.
      Title: TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1.
    2. On day 104 of pregnancy, mRNA expression of TLRs 3 and 8, as well as that of TLRs 7 and 9, was high in the spleen of fetuses from Neospora caninum-infected heifers. Gene expression levels of endosomal TLRs were also detectable in the placenta and the maternal caruncle from infected heifers, being TLRs 3, 7 and 8 particularly upregulated, mostly in the caruncle.
      Title: Toll-like receptors 3, 7 and 8 are upregulated in the placental caruncle and fetal spleen of Neospora caninum experimentally infected cattle.
    3. The results from this study demonstrate that expression of at least TLR3, TLR7 and TLR8 is stimulated upon bovine alpha-herpesvirus infection of the brain.
      Title: Involvement of toll-like receptors 3 and 7/8 in the neuropathogenesis of bovine herpesvirus types 1 and 5.
    4. Knockdown TLR8 increased the apoptosis induced by Bacillus Calmette Guerin infection, and this enhanced apoptosis was caspase-dependent.
      Title: Inhibition of TLR8 mediated signaling promotes BCG induced apoptosis in THP-1 cells.
    5. A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition.
      Title: A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition.
    6. a ligand-induced dimer conformational switch is mainly responsible for TLR8 activation.
      Title: Characterization of bovine Toll-like receptor 8: ligand specificity, signaling essential sites and dimerization.
    7. multiple regions, including ECD, TM, linker and TIR-tail regions of bTLR8, are involved in determining the localization of cellular ER compartment.
      Title: Multiple molecular regions confer intracellular localization of bovine Toll-like receptor 8.
    8. Comparative sequence analysis revealed a total of 139 polymorphisms, which include single-nucleotide polymorphisms and insertion-deletion polymorphisms.
      Title: Detection of polymorphisms in bovine toll-like receptors 3, 7, 8, and 9.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables pattern recognition receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    toll-like receptor 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033937.1 → NP_001029109.1  toll-like receptor 8 precursor

      See identical proteins and their annotated locations for NP_001029109.1

      Status: PROVISIONAL

      Source sequence(s)
      AY642125
      UniProtKB/TrEMBL
      F1APS9, Q3MND9
      Conserved Domains (5) summary
      smart00082
      Location:755 → 803
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:863 → 999
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:57 → 332
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:62 → 85
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:624 → 683
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      130727684..130745770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005228490.5 → XP_005228547.1  toll-like receptor 8 isoform X1

      See identical proteins and their annotated locations for XP_005228547.1

      UniProtKB/TrEMBL
      F1APS9, F1APT0
      Related
      ENSBTAP00000082601.1, ENSBTAT00000109053.1
      Conserved Domains (5) summary
      TIGR00864
      Location:734 → 817
      PCC; polycystin cation channel protein
      smart00255
      Location:872 → 1008
      TIR; Toll - interleukin 1 - resistance
      PLN00113
      Location:62 → 587
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:62 → 85
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:627 → 766
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. XM_059883464.1 → XP_059739447.1  toll-like receptor 8 isoform X2

      UniProtKB/TrEMBL
      F1APS9

    3. XM_005228488.5 → XP_005228545.1  toll-like receptor 8 isoform X1

      See identical proteins and their annotated locations for XP_005228545.1

      UniProtKB/TrEMBL
      F1APS9, F1APT0
      Related
      ENSBTAP00000079093.1, ENSBTAT00000133809.1
      Conserved Domains (5) summary
      TIGR00864
      Location:734 → 817
      PCC; polycystin cation channel protein
      smart00255
      Location:872 → 1008
      TIR; Toll - interleukin 1 - resistance
      PLN00113
      Location:62 → 587
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:62 → 85
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:627 → 766
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    4. XM_005228489.5 → XP_005228546.1  toll-like receptor 8 isoform X1

      See identical proteins and their annotated locations for XP_005228546.1

      UniProtKB/TrEMBL
      F1APS9, F1APT0
      Related
      ENSBTAP00000097153.1, ENSBTAT00000090087.1
      Conserved Domains (5) summary
      TIGR00864
      Location:734 → 817
      PCC; polycystin cation channel protein
      smart00255
      Location:872 → 1008
      TIR; Toll - interleukin 1 - resistance
      PLN00113
      Location:62 → 587
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:62 → 85
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:627 → 766
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    5. XM_059883462.1 → XP_059739445.1  toll-like receptor 8 isoform X1

      UniProtKB/TrEMBL
      F1APS9, F1APT0
      Related
      ENSBTAP00000094178.1, ENSBTAT00000113155.1

    6. XM_059883463.1 → XP_059739446.1  toll-like receptor 8 isoform X1

      UniProtKB/TrEMBL
      F1APS9, F1APT0
      Related
      ENSBTAP00000075850.1, ENSBTAT00000101319.1

    7. XM_024988093.2 → XP_024843861.1  toll-like receptor 8 isoform X1

      UniProtKB/TrEMBL
      F1APS9, F1APT0
      Conserved Domains (5) summary
      TIGR00864
      Location:734 → 817
      PCC; polycystin cation channel protein
      smart00255
      Location:872 → 1008
      TIR; Toll - interleukin 1 - resistance
      PLN00113
      Location:62 → 587
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:62 → 85
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:627 → 766
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein Strain
    Heading Accession and Version

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