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    EIF4G2 eukaryotic translation initiation factor 4 gamma 2 [ Homo sapiens (human) ]

    Gene ID: 1982, updated on 28-Oct-2024

    Summary

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    Official Symbol
    EIF4G2provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4 gamma 2provided by HGNC
    Primary source
    HGNC:HGNC:3297
    See related
    Ensembl:ENSG00000110321 MIM:602325; AllianceGenome:HGNC:3297
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P97; AAG1; DAP5; NAT1
    Summary
    Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 207.4), placenta (RPKM 201.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EIF4G2 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (10797046..10808926, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (10881950..10893905, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (10818593..10830473, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene IRAG1 antisense RNA 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:10615146-10616345 Neighboring gene inositol 1,4,5-triphosphate receptor associated 1 Neighboring gene Sharpr-MPRA regulatory regions 8950 and 14430 Neighboring gene MPRA-validated peak1195 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4441 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:10678394-10679593 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:10680716-10681915 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:10696121-10696708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:10697483-10697984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4444 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:10772162-10772662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4447 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:10785333-10786532 Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:10813405-10813954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:10813955-10814504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4450 Neighboring gene uncharacterized LOC101928053 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:10830951-10831557 Neighboring gene small nucleolar RNA, C/D box 97 Neighboring gene Sharpr-MPRA regulatory region 5180 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:10870572-10870772 Neighboring gene MPRA-validated peak1197 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4451 Neighboring gene zinc finger BED-type containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray diffraction analysis of the MIF4G domain of DAP5. Frank F, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Jan 1. PMID 20057060, Free PMC Article
    2. DAP5 ameliorates cisplatin-induced apoptosis of renal tubular cells. Gao JJ, et al. Am J Nephrol, 2012. PMID 22555068
    3. DAP5 drives translation of specific mRNA targets with upstream ORFs in human embryonic stem cells. David M, et al. RNA, 2022 Oct. PMID 35961752, Free PMC Article
    4. Suppression of cap-dependent translation in mitosis. Pyronnet S, et al. Genes Dev, 2001 Aug 15. PMID 11511540, Free PMC Article
    5. Crystal structure of the C-terminal region of human p97/DAP5. Fan S, et al. Proteins, 2010 Aug 1. PMID 20544972

    See all (180) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-877-5p promotes osteoblast differentiation by targeting EIF4G2 expression.
      Title: MicroRNA-877-5p promotes osteoblast differentiation by targeting EIF4G2 expression.
    2. Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor.
      Title: Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor.
    3. miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2.
      Title: miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2.
    4. Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation.
      Title: Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation.
    5. Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity.
      Title: Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity.
    6. Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation.
      Title: Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation.
    7. DAP5 drives translation of specific mRNA targets with upstream ORFs in human embryonic stem cells.
      Title: DAP5 drives translation of specific mRNA targets with upstream ORFs in human embryonic stem cells.
    8. Circular RNA-UBE2D2 accelerates the proliferation and metastasis of non-small cell lung cancer cells via modulating microRNA-376a-3p/Eukaryotic Translation Initiation Factor 4gamma2 axis.
      Title: Circular RNA-UBE2D2 accelerates the proliferation and metastasis of non-small cell lung cancer cells via modulating microRNA-376a-3p/Eukaryotic Translation Initiation Factor 4γ2 axis.
    9. Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant.
      Title: Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant.
    10. A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells.
      Title: A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: ZBED5

    Homology

    Clone Names

    • FLJ41344

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables cadherin binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation factor activity, RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell death TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macromolecule biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction HDA PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4 gamma 2
    Names
    DAP-5
    aging-associated protein 1
    death-associated protein 5
    eIF-4-gamma 2
    eIF-4G 2
    eIF4G 2
    eukaryotic translation initiation factor 4G-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042559.3 → NP_001036024.3  eukaryotic translation initiation factor 4 gamma 2 isoform 2

      See identical proteins and their annotated locations for NP_001036024.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AI362365, BC111548, DB072494, DB272352
      Consensus CDS
      CCDS41618.1
      UniProtKB/TrEMBL
      H0Y3P2
      Related
      ENSP00000379778.3, ENST00000396525.7
      Conserved Domains (4) summary
      cd11559
      Location:702 → 838
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      smart00544
      Location:506 → 619
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:78 → 308
      MIF4G; MIF4G domain
      pfam11235
      Location:413 → 513
      Med25_SD1; Mediator complex subunit 25 synapsin 1

    2. NM_001172705.1 → NP_001166176.1  eukaryotic translation initiation factor 4 gamma 2 isoform 1

      See identical proteins and their annotated locations for NP_001166176.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AI362365, BC065276, DB231980, DB272352
      Consensus CDS
      CCDS31428.1
      UniProtKB/Swiss-Prot
      O60877, P78344, P78404, Q0VH00, Q0VH01, Q2NKW9, Q49A79, Q53EU1, Q58EZ2, Q8NI71, Q96C16
      UniProtKB/TrEMBL
      D3DQV9
      Related
      ENSP00000433664.2, ENST00000526148.6
      Conserved Domains (3) summary
      cd11559
      Location:740 → 876
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      smart00544
      Location:544 → 657
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:78 → 308
      MIF4G; MIF4G domain

    3. NM_001418.4 → NP_001409.3  eukaryotic translation initiation factor 4 gamma 2 isoform 1

      See identical proteins and their annotated locations for NP_001409.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AK223548, DB272352
      Consensus CDS
      CCDS31428.1
      UniProtKB/Swiss-Prot
      O60877, P78344, P78404, Q0VH00, Q0VH01, Q2NKW9, Q49A79, Q53EU1, Q58EZ2, Q8NI71, Q96C16
      UniProtKB/TrEMBL
      D3DQV9
      Related
      ENSP00000340281.6, ENST00000339995.11
      Conserved Domains (3) summary
      cd11559
      Location:740 → 876
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      smart00544
      Location:544 → 657
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:78 → 308
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      10797046..10808926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      10881950..10893905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78344.1 GenPept UniProtKB/Swiss-Prot:P78344

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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