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    ACOT7 acyl-CoA thioesterase 7 [ Homo sapiens (human) ]

    Gene ID: 11332, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ACOT7provided by HGNC
    Official Full Name
    acyl-CoA thioesterase 7provided by HGNC
    Primary source
    HGNC:HGNC:24157
    See related
    Ensembl:ENSG00000097021 MIM:602587; AllianceGenome:HGNC:24157
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACT; ACH1; BACH; LACH; LACH1; hBACH; CTE-II
    Summary
    This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 26.5), kidney (RPKM 21.3) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ACOT7 in Genome Data Viewer
    Location:
    1p36.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (6264272..6393767, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (5789916..5919409, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6324332..6453827, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6304377-6304934 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6305171-6305522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6309743-6310284 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 150 Neighboring gene G protein-coupled receptor 153 Neighboring gene hes family bHLH transcription factor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6329739-6330330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6330331-6330921 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6333683-6333849 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6335064-6335654 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6339577-6340442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6340686-6341235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 76 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:6361272-6362471 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6396158-6396892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6397980-6398642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6398643-6399303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6399966-6400626 Neighboring gene Sharpr-MPRA regulatory region 5603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6417160-6418127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 78 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 79 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 80 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6424607-6425106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6427779-6428559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6434479-6434978 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6445825-6446810 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:6453176-6453687 and GRCh37_chr1:6453688-6454200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:6454201-6454711 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6455464-6455988 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:6474153-6474654 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:6474655-6475154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6483551-6484165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6484166-6484779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 82 Neighboring gene hes family bHLH transcription factor 2 Neighboring gene microRNA 4252 Neighboring gene espin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy. Yang JW, et al. Amino Acids, 2004 Dec. PMID 15592755
    2. Long-chain acyl-CoA hydrolase in the brain. Yamada J. Amino Acids, 2005 May. PMID 15731883
    3. Expression level of ACOT7 influences the prognosis in acute myeloid leukemia patients. Zhang X, et al. Cancer Biomark, 2019. PMID 31640082
    4. USP3 promotes cisplatin resistance in non-small cell lung cancer cells by suppressing ACOT7-regulated ferroptosis. Tao R, et al. Anticancer Drugs, 2024 Jul 1. PMID 38502867
    5. Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. Yamada J, et al. J Biochem, 1999 Dec. PMID 10578051

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USP3 promotes cisplatin resistance in non-small cell lung cancer cells by suppressing ACOT7-regulated ferroptosis.
      Title: USP3 promotes cisplatin resistance in non-small cell lung cancer cells by suppressing ACOT7-regulated ferroptosis.
    2. Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.
      Title: Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.
    3. NMRAL2P activation suppresses ACOT7 expression in gastric cancer.
      Title: Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression.
    4. Patients in high ACOT7 group had a significant lower EFS and OS, while patients in high versus low expression levels of other types of ACOT showed no significant difference on the outcome
      Title: Expression level of ACOT7 influences the prognosis in acute myeloid leukemia patients.
    5. PKCzeta was specifically involved in ACOT7 depletion-mediated cell cycle arrest as an upstream molecule of the p53-p21 signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells.
      Title: Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ-p53-p21 signaling pathway.
    6. WIG1 governs the miRNA-dependent and the miRNA-independent recruitment of AGO2 to lower the stability of and suppress the translation of ACOT7 mRNA.
      Title: WIG1 is crucial for AGO2-mediated ACOT7 mRNA silencing via miRNA-dependent and -independent mechanisms.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
    8. the human BACH gene can express long-chain acyl-CoA hydrolase activity in multiple intracellular compartments by generating BACH isoforms with differential localization signals to affect various cellular functions that involve acyl-CoAs
      Title: Human brain acyl-CoA hydrolase isoforms encoded by a single gene.
    9. BACH was deranged in hippocampus of mesial temporal lobe epilepsy patients.
      Title: Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variants at ten loci influence QT interval duration in the QTGEN Study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC1126

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty-acyl-CoA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acyl-CoA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty-acyl-CoA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in medium-chain fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in medium-chain fatty-acyl-CoA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in palmitic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic acyl coenzyme A thioester hydrolase
    Names
    CTE-IIa
    acyl-CoA thioesterase 2
    acyl-CoA thioesterase, long chain
    brain acyl-CoA hydrolase
    long chain acyl-CoA thioester hydrolase
    NP_009205.3
    NP_863654.1
    NP_863655.1
    NP_863656.1
    XP_047299355.1
    XP_054190023.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007274.4 → NP_009205.3  cytosolic acyl coenzyme A thioester hydrolase isoform hBACHa

      See identical proteins and their annotated locations for NP_009205.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (hBACHa) differs in the 5' UTR and 5' coding region, compared to variant hBACHb. It encodes isoform hBACHa that has a shorter and distinct N-terminus lacking a mitochondrial targetting sequence, compared to isoform hBACHb.
      Source sequence(s)
      AL031847, AL031848
      Consensus CDS
      CCDS30573.1
      UniProtKB/Swiss-Prot
      O00154
      Related
      ENSP00000354615.4, ENST00000361521.9
      Conserved Domains (1) summary
      cd03442
      Location:212 → 335
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

    2. NM_181864.3 → NP_863654.1  cytosolic acyl coenzyme A thioester hydrolase isoform hBACHb

      See identical proteins and their annotated locations for NP_863654.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (hBACHb) encodes the longest isoform (hBACHb), which may be targetted to the mitochondria.
      Source sequence(s)
      AL031847, AL031848, BC017365, BM807217
      Consensus CDS
      CCDS65.1
      UniProtKB/Swiss-Prot
      A8K0K7, A8K232, A8K6B8, A8K837, B3KQ12, O00154, O43703, Q53Y78, Q5JYL2, Q5JYL3, Q5JYL4, Q5JYL5, Q5JYL6, Q5TGR4, Q9UJM9, Q9Y539, Q9Y540
      Related
      ENSP00000367086.2, ENST00000377855.6
      Conserved Domains (1) summary
      cd03442
      Location:222 → 345
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

    3. NM_181865.3 → NP_863655.1  cytosolic acyl coenzyme A thioester hydrolase isoform hBACHc

      See identical proteins and their annotated locations for NP_863655.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (hBACHc) differs in the 5' UTR and 5' coding region, compared to variant hBACHb. It encodes isoform hBACHc that has a shorter and distinct N-terminus, compared to isoform hBACHb, and may also be targetted to the mitochondria.
      Source sequence(s)
      AB074418, AL031848, BC017365, BU594651
      Consensus CDS
      CCDS66.1
      UniProtKB/Swiss-Prot
      O00154
      Related
      ENSP00000367076.3, ENST00000377845.7
      Conserved Domains (1) summary
      cd03442
      Location:192 → 315
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

    4. NM_181866.3 → NP_863656.1  cytosolic acyl coenzyme A thioester hydrolase isoform hBACHd

      See identical proteins and their annotated locations for NP_863656.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (hBACHd) differs in the 5' UTR and 5' coding region, compared to variant hBACHb. It encodes isoform hBACHd that has a shorter and distinct N-terminus lacking a mitochondrial targetting sequence, compared to isoform hBACHb.
      Source sequence(s)
      AB074419, BC017365, BQ067921
      Consensus CDS
      CCDS67.1
      UniProtKB/TrEMBL
      K7EKP8
      Related
      ENSP00000367073.3, ENST00000377842.7
      Conserved Domains (2) summary
      cd03442
      Location:171 → 294
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
      pfam16136
      Location:134 → 156
      NINJA_B; Putative nuclear localization signal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      6264272..6393767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443399.1 → XP_047299355.1  cytosolic acyl coenzyme A thioester hydrolase isoform X1

      Related
      ENSP00000465719.1, ENST00000473466.2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      5789916..5919409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334048.1 → XP_054190023.1  cytosolic acyl coenzyme A thioester hydrolase isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181862.2: Suppressed sequence

      Description
      NM_181862.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_181863.2: Suppressed sequence

      Description
      NM_181863.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00154.3 GenPept UniProtKB/Swiss-Prot:O00154

    Gene LinkOut

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