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    ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) [ Homo sapiens (human) ]

    Gene ID: 957, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ENTPD5provided by HGNC
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 5 (inactive)provided by HGNC
    Primary source
    HGNC:HGNC:3367
    See related
    Ensembl:ENSG00000187097 MIM:603162; AllianceGenome:HGNC:3367
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCPH; CD39L4; NTPDase-5
    Summary
    The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]
    Expression
    Broad expression in liver (RPKM 43.1), colon (RPKM 29.4) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ENTPD5 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (73955329..74019288, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68162983..68226953, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74422032..74485991, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74318268-74318670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8721 Neighboring gene prostaglandin reductase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8722 Neighboring gene zinc finger protein 410 Neighboring gene FAM161 centrosomal protein B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:74416687-74417687 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74418757-74419055 Neighboring gene coenzyme Q6, monooxygenase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:74459045-74459546 Neighboring gene Sharpr-MPRA regulatory region 8014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5926 Neighboring gene Sharpr-MPRA regulatory regions 4216 and 10298 Neighboring gene ribosomal protein L41 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36659 Neighboring gene basal body orientation factor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74530601-74530820 Neighboring gene aldehyde dehydrogenase 6 family member A1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8725 Neighboring gene RNY4 pseudogene 21 Neighboring gene lin-52 DREAM MuvB core complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme. Zadran S, et al. Tumour Biol, 2012 Dec. PMID 22992974
    2. ENTPD5 splice variants: novel players in cancer? Arruga F. Purinergic Signal, 2021 Sep. PMID 34272651, Free PMC Article
    3. ENTPD5: identification of splicing variants and their impact on cancer survival. de Campos RP, et al. Purinergic Signal, 2021 Sep. PMID 34075526, Free PMC Article
    4. [ENTPD5 gene is highly expressed in epithelial ovarian cancer: analysis based on Oncomine database and bioinformatics]. Wang H, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2021 Apr 20. PMID 33963715, Free PMC Article
    5. The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells. Recio JA, et al. Mol Carcinog, 2000 Mar. PMID 10708485

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation.
      Title: The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation.
    2. ENTPD5 splice variants: novel players in cancer?
      Title: ENTPD5 splice variants: novel players in cancer?
    3. ENTPD5: identification of splicing variants and their impact on cancer survival.
      Title: ENTPD5: identification of splicing variants and their impact on cancer survival.
    4. [ENTPD5 gene is highly expressed in epithelial ovarian cancer: analysis based on Oncomine database and bioinformatics].
      Title: [ENTPD5 gene is highly expressed in epithelial ovarian cancer: analysis based on Oncomine database and bioinformatics].
    5. ENTPD5 is a mediator of mutant p53 gain of function activity in clonogenic growth, architectural tissue remodeling, migration, invasion, and lung colonization in lung cancer and its mouse models
      Title: Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.
    6. Results suggest that ENTPD5 affects lung cancer apoptosis via Caspase 3 pathway, and can be potentially used to monitor prognosis or to guide appropriate therapeutic regimens.
      Title: ENTPD5 induces apoptosis in lung cancer cells via regulating caspase 3 expression.
    7. The main point of this review is to integrate the findings and proposed theories about the role played by NTPDase5/mt-PCPH in cancer progression, considering that these proteins have been suggested as potential early diagnostic tools and therapy targets.
      Title: NTPDase5/PCPH as a new target in highly aggressive tumors: a systematic review.
    8. These results strongly suggest that the mt-PCPH ( ENTPD5)oncoprotein may regulate the cellular energy levels and subsequent chemoresistance by an NTPDase-independent mechanism
      Title: The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family.
    9. Upregulation of ENTPD5 is associated with altered metabolism in gliomablastoma multiforme.
      Title: ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme.
    10. The elevation of ENTPD5 activity therefore protects AKT-active cancer cells from protein-overloading-induced endoplasmic reticulum stress and the resulting growth arrest and apoptosis.
      Title: ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC163357, MGC163359

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables IDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect 'de novo' post-translational protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in UDP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_positive_effect UDP-glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleoside diphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_positive_effect protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nucleoside diphosphate phosphatase ENTPD5
    Names
    CD39 antigen-like 4
    CD39-like 4
    ER-UDPase
    GDPase ENTPD5
    NTPDase 5
    Pcph proto-oncogene protein
    UDPase ENTPD5
    guanosine-diphosphatase ENTPD5
    inosine diphosphate phosphatase ENTPD5
    nucleoside diphosphatase
    proto-oncogene CPH
    uridine-diphosphatase ENTPD5
    NP_001240.1
    NP_001308913.1
    NP_001308914.1
    NP_001308915.1
    NP_001308916.1
    NP_001308917.1
    NP_001317118.1
    NP_001369185.1
    NP_001369186.1
    NP_001369187.1
    NP_001369188.1
    NP_001369189.1
    NP_001369191.1
    NP_001369192.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001249.5 → NP_001240.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001240.1

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Related
      ENSP00000335246.6, ENST00000334696.11
      Conserved Domains (1) summary
      cl17037
      Location:39 → 424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. NM_001321984.2 → NP_001308913.1  nucleoside diphosphate phosphatase ENTPD5 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Conserved Domains (1) summary
      cl17037
      Location:39 → 400
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. NM_001321985.3 → NP_001308914.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Conserved Domains (1) summary
      cl17037
      Location:39 → 424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    4. NM_001321986.3 → NP_001308915.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Conserved Domains (1) summary
      cl17037
      Location:39 → 424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    5. NM_001321987.3 → NP_001308916.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Conserved Domains (1) summary
      cl17037
      Location:39 → 424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    6. NM_001321988.3 → NP_001308917.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Conserved Domains (1) summary
      cl17037
      Location:39 → 424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    7. NM_001330189.2 → NP_001317118.1  nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484, AW028387
      Consensus CDS
      CCDS81825.1
      UniProtKB/TrEMBL
      G3V4I0
      Conserved Domains (1) summary
      cl17037
      Location:39 → 404
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    8. NM_001382256.1 → NP_001369185.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Conserved Domains (1) summary
      cl17037
      Location:39 → 424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    9. NM_001382257.1 → NP_001369186.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS9825.1
      UniProtKB/Swiss-Prot
      A1L4C5, O75356, Q96RX0
      Conserved Domains (1) summary
      cl17037
      Location:39 → 424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    10. NM_001382258.1 → NP_001369187.1  nucleoside diphosphate phosphatase ENTPD5 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Conserved Domains (1) summary
      cl17037
      Location:39 → 410
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    11. NM_001382259.1 → NP_001369188.1  nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS81825.1
      UniProtKB/TrEMBL
      G3V4I0
      Related
      ENSP00000451810.1, ENST00000557325.5
      Conserved Domains (1) summary
      cl17037
      Location:39 → 404
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    12. NM_001382260.1 → NP_001369189.1  nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Consensus CDS
      CCDS81825.1
      UniProtKB/TrEMBL
      G3V4I0
      Conserved Domains (1) summary
      cl17037
      Location:39 → 404
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    13. NM_001382262.1 → NP_001369191.1  nucleoside diphosphate phosphatase ENTPD5 isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Conserved Domains (1) summary
      cl17037
      Location:39 → 396
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    14. NM_001382263.1 → NP_001369192.1  nucleoside diphosphate phosphatase ENTPD5 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005480, AC005484
      Conserved Domains (1) summary
      cl17037
      Location:39 → 377
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      73955329..74019288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      68162983..68226953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75356.1 GenPept UniProtKB/Swiss-Prot:O75356

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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