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    Elf5 E74-like factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 13711, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Elf5provided by MGI
    Official Full Name
    E74-like factor 5provided by MGI
    Primary source
    MGI:MGI:1335079
    See related
    Ensembl:ENSMUSG00000027186 AllianceGenome:MGI:1335079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESE-2; ESE-5; ESE-5.
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including ectodermal cell fate commitment; mammary gland epithelial cell differentiation; and negative regulation of cell differentiation involved in embryonic placenta development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; integumental system; and respiratory system epithelium. Orthologous to human ELF5 (E74 like ETS transcription factor 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 8.8), mammary gland adult (RPKM 6.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Elf5 in Genome Data Viewer
    Location:
    2 E2; 2 54.43 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103242443..103281334)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103412098..103450989)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930006I01 gene Neighboring gene STARR-seq mESC enhancer starr_05269 Neighboring gene cDNA sequence BC016548 Neighboring gene STARR-seq mESC enhancer starr_05270 Neighboring gene STARR-positive B cell enhancer ABC_E811 Neighboring gene catalase Neighboring gene RIKEN cDNA 8030431J09 gene Neighboring gene STARR-positive B cell enhancer ABC_E7843 Neighboring gene STARR-positive B cell enhancer ABC_E812 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103408122-103408323 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene VISTA enhancer mm1312

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ELF5-Mediated AR Activation Regulates Prostate Cancer Progression. Li K, et al. Sci Rep, 2017 Mar 13. PMID 28287091, Free PMC Article
    2. Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling. Chakrabarti R, et al. Stem Cells, 2012 Jul. PMID 22523003, Free PMC Article
    3. The transcription factor ELF5 is essential for early preimplantation development. Alotaibi H. Mol Biol Rep, 2023 Mar. PMID 36542237
    4. Lineage specific methylation of the Elf5 promoter in mammary epithelial cells. Lee HJ, et al. Stem Cells, 2011 Oct. PMID 21823211
    5. Generation and analysis of Elf5-LacZ mouse: unique and dynamic expression of Elf5 (ESE-2) in the inner root sheath of cycling hair follicles. Choi YS, et al. Histochem Cell Biol, 2008 Jan. PMID 17938949

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma.
      Title: ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma.
    2. The transcription factor ELF5 is essential for early preimplantation development.
      Title: The transcription factor ELF5 is essential for early preimplantation development.
    3. MicroRNA-148a Controls Epidermal and Hair Follicle Stem/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5.
      Title: MicroRNA-148a Controls Epidermal and Hair Follicle Stem/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5.
    4. Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland.
      Title: Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland.
    5. Downregulation of ELF5 increases the expression of AR-response genes and the progression of prostate cancer. ELF5 interaction with AR is androgen dependent.
      Title: ELF5-Mediated AR Activation Regulates Prostate Cancer Progression.
    6. Conditional inactivation of Elf5 in the developing collecting ducts results in a small but significant reduction in the expression levels of Aqp2 and Avpr2 genes.
      Title: Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression.
    7. Mechanistically, RL negatively regulates Stat5 phosphorylation and Elf5 expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin/p-Stat5 pathway.
      Title: Rankl Impairs Lactogenic Differentiation Through Inhibition of the Prolactin/Stat5 Pathway at Midgestation.
    8. Elf5 at the center of a stoichiometry-sensitive transcriptional network, where it acts as a molecular switch governing the balance between TSC proliferation and differentiation
      Title: Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks.
    9. Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner
      Title: Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner.
    10. Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression.
      Title: Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ectoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ectodermal cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within mammary gland epithelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell differentiation involved in embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of trophoblast giant cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ETS-related transcription factor Elf-5
    Names
    Epithelium specific Ets-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145813.1 → NP_001139285.1  ETS-related transcription factor Elf-5

      See identical proteins and their annotated locations for NP_001139285.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AK132484, AL773505
      Consensus CDS
      CCDS16477.1
      UniProtKB/Swiss-Prot
      Q8VDK3, Q921H5, Q9Z2K6
      UniProtKB/TrEMBL
      Q3ULZ4, Q3V1F7
      Related
      ENSMUSP00000126941.2, ENSMUST00000164172.8
      Conserved Domains (2) summary
      cd08538
      Location:39 → 122
      SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
      smart00413
      Location:162 → 246
      ETS; erythroblast transformation specific domain

    2. NM_010125.3 → NP_034255.2  ETS-related transcription factor Elf-5

      See identical proteins and their annotated locations for NP_034255.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AF049702, AK132484, AK145214, AL773505
      Consensus CDS
      CCDS16477.1
      UniProtKB/Swiss-Prot
      Q8VDK3, Q921H5, Q9Z2K6
      UniProtKB/TrEMBL
      Q3ULZ4, Q3V1F7
      Related
      ENSMUSP00000028609.8, ENSMUST00000028609.14
      Conserved Domains (2) summary
      cd08538
      Location:39 → 122
      SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
      smart00413
      Location:162 → 246
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      103242443..103281334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498705.3 → XP_006498768.1  ETS-related transcription factor Elf-5 isoform X1

      See identical proteins and their annotated locations for XP_006498768.1

      UniProtKB/Swiss-Prot
      Q8VDK3, Q921H5, Q9Z2K6
      UniProtKB/TrEMBL
      Q3ULZ4, Q3V1F7
      Conserved Domains (2) summary
      cd08538
      Location:39 → 122
      SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
      smart00413
      Location:162 → 246
      ETS; erythroblast transformation specific domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDK3.2 GenPept UniProtKB/Swiss-Prot:Q8VDK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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