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    FCGR1A Fc gamma receptor Ia [ Homo sapiens (human) ]

    Gene ID: 2209, updated on 28-Oct-2024

    Summary

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    Official Symbol
    FCGR1Aprovided by HGNC
    Official Full Name
    Fc gamma receptor Iaprovided by HGNC
    Primary source
    HGNC:HGNC:3613
    See related
    Ensembl:ENSG00000150337 MIM:146760; AllianceGenome:HGNC:3613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD64; FCG1; FCRI; CD64A; FCGR1; IGFR1; FcgammaRI
    Summary
    This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in appendix (RPKM 19.0), placenta (RPKM 13.4) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FCGR1A in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149782694..149800609)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (148906840..148924747)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149754250..149772165)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371406 Neighboring gene ubiquitin conjugating enzyme E2 D4 (putative) pseudogene Neighboring gene tRNA-Arg (anticodon CCT) 8-1 Neighboring gene MPRA-validated peak406 silencer Neighboring gene uncharacterized LOC124904411 Neighboring gene H2B clustered histone 18 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149764669-149765433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1654 Neighboring gene H3 clustered histone 13 Neighboring gene H4 clustered histone 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy. Valerius T, et al. Blood, 1993 Aug 1. PMID 7687898
    2. Engineering of recombinant human Fcγ receptor I by directed evolution. Asaoka Y, et al. Protein Eng Des Sel, 2012 Dec. PMID 22967788
    3. Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization. Takai S, et al. Hum Genet, 1994 Jan. PMID 8270248
    4. The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy. Mancardi DA, et al. Blood, 2013 Feb 28. PMID 23293080
    5. Neutrophil CD64 for daily surveillance of systemic infection and necrotizing enterocolitis in preterm infants. Lam HS, et al. Clin Chem, 2013 Dec. PMID 24046202

    See all (180) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis.
      Title: Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis.
    2. A Non-Coding Fc Gamma Receptor Cis-Regulatory Variant within the 1q23 Gene Cluster Is Associated with Plasmodium falciparum Infection in Children Residing in Burkina Faso.
      Title: A Non-Coding Fc Gamma Receptor Cis-Regulatory Variant within the 1q23 Gene Cluster Is Associated with Plasmodium falciparum Infection in Children Residing in Burkina Faso.
    3. Prognostic performance of neutrophil CD64 expression in patients with complicated intra-abdominal infections - a prospective study.
      Title: Prognostic performance of neutrophil CD64 expression in patients with complicated intra-abdominal infections - a prospective study.
    4. CD64 expression on neutrophils as a potential biomarker for bacterial infection in ascitic fluid of cirrhotic patients.
      Title: CD64 expression on neutrophils as a potential biomarker for bacterial infection in ascitic fluid of cirrhotic patients.
    5. Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study.
      Title: Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study.
    6. Novel Human FCGR1A Variants Affect CD64 Functions and Are Risk Factors for Sarcoidosis.
      Title: Novel Human FCGR1A Variants Affect CD64 Functions and Are Risk Factors for Sarcoidosis.
    7. Soluble FcgammaRIA expressed on monocytes (sCD64): A new serum biomarker of acute kidney injury in patients with suspected infection at emergency department admission.
      Title: Soluble FcγRIA expressed on monocytes (sCD64): A new serum biomarker of acute kidney injury in patients with suspected infection at emergency department admission.
    8. Fcgamma receptor activation mediates vascular inflammation and abdominal aortic aneurysm development.
      Title: Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development.
    9. Utility of neutrophil CD64 in distinguishing bacterial infection from inflammation in severe alcoholic hepatitis fulfilling SIRS criteria.
      Title: Utility of neutrophil CD64 in distinguishing bacterial infection from inflammation in severe alcoholic hepatitis fulfilling SIRS criteria.
    10. CD169 and CD64 could help differentiate bacterial from CoVID-19 or other viral infections in the Emergency Department.
      Title: CD169 and CD64 could help differentiate bacterial from CoVID-19 or other viral infections in the Emergency Department.
    Submit: New GeneRIF Correction See all GeneRIFs (133)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
    Nef nef HIV-1 Nef downregulates Fc-gamma Receptor I in human monocytes/macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ18345

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgG binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables IgG receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables high-affinity IgG receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in antibody-dependent cellular cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antibody-dependent cellular cytotoxicity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phagocytosis, engulfment IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phagocytosis, recognition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of type III hypersensitivity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of type IIa hypersensitivity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in clathrin-coated endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in early endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    high affinity immunoglobulin gamma Fc receptor I
    Names
    Fc fragment of IgG receptor Ia
    Fc fragment of IgG, high affinity Ia, receptor (CD64)
    Fc fragment of IgG, high affinity Ia, receptor for (CD64)
    Fc-gamma RI
    Fc-gamma receptor I A1
    IgG Fc receptor I
    fc-gamma RIA
    fcgammaRIa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007578.1 RefSeqGene

      Range
      4963..14787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_59

    mRNA and Protein(s)

    1. NM_000566.4 → NP_000557.1  high affinity immunoglobulin gamma Fc receptor I isoform 2 precursor

      See identical proteins and their annotated locations for NP_000557.1

      Status: REVIEWED

      Source sequence(s)
      AC243772
      Consensus CDS
      CCDS933.1
      UniProtKB/Swiss-Prot
      P12314, P12315, Q5QNW7, Q92495, Q92663
      Related
      ENSP00000358165.4, ENST00000369168.5
      Conserved Domains (3) summary
      cd05752
      Location:22 → 100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:104 → 185
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      pfam00047
      Location:196 → 274
      ig; Immunoglobulin domain

    2. NM_001378804.1 → NP_001365733.1  high affinity immunoglobulin gamma Fc receptor I isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243772
      Conserved Domains (3) summary
      pfam00047
      Location:197 → 275
      ig; Immunoglobulin domain
      cd05752
      Location:23 → 101
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:105 → 186
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

    3. NM_001378805.1 → NP_001365734.1  high affinity immunoglobulin gamma Fc receptor I isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243772
      Conserved Domains (3) summary
      pfam00047
      Location:189 → 267
      ig; Immunoglobulin domain
      cd05752
      Location:15 → 93
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:97 → 178
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

    4. NM_001378806.1 → NP_001365735.1  high affinity immunoglobulin gamma Fc receptor I isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243772
      Conserved Domains (3) summary
      pfam00047
      Location:196 → 274
      ig; Immunoglobulin domain
      cd05752
      Location:22 → 100
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:104 → 185
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

    5. NM_001378807.1 → NP_001365736.1  high affinity immunoglobulin gamma Fc receptor I isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC243772
      Conserved Domains (3) summary
      pfam00047
      Location:173 → 251
      ig; Immunoglobulin domain
      cd05752
      Location:5 → 77
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:81 → 162
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

    6. NM_001378808.1 → NP_001365737.1  high affinity immunoglobulin gamma Fc receptor I isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243772
      Conserved Domains (2) summary
      pfam00047
      Location:112 → 190
      ig; Immunoglobulin domain
      cd05752
      Location:22 → 100
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

    7. NM_001378809.1 → NP_001365738.1  high affinity immunoglobulin gamma Fc receptor I isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243772
      UniProtKB/TrEMBL
      C9JSN8
      Conserved Domains (3) summary
      pfam00047
      Location:111 → 189
      ig; Immunoglobulin domain
      cd00096
      Location:122 → 128
      Ig; Ig strand B [structural motif]
      cd05753
      Location:19 → 100
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

    8. NM_001378810.1 → NP_001365739.1  high affinity immunoglobulin gamma Fc receptor I isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243772
      UniProtKB/TrEMBL
      C9JSN8
      Related
      ENSP00000394279.1, ENST00000444948.5
      Conserved Domains (3) summary
      pfam00047
      Location:104 → 182
      ig; Immunoglobulin domain
      cd00096
      Location:115 → 121
      Ig; Ig strand B [structural motif]
      cd05753
      Location:16 → 93
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

    9. NM_001378811.1 → NP_001365740.1  high affinity immunoglobulin gamma Fc receptor I isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243772
      UniProtKB/TrEMBL
      C9JSN8
      Conserved Domains (3) summary
      pfam00047
      Location:104 → 182
      ig; Immunoglobulin domain
      cd00096
      Location:115 → 121
      Ig; Ig strand B [structural motif]
      cd05753
      Location:16 → 93
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

    RNA

    1. NR_166121.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC243772

    2. NR_166122.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC243772

    3. NR_166123.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC243772

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      149782694..149800609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      148906840..148924747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12314.2 GenPept UniProtKB/Swiss-Prot:P12314

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous