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    Dus1l dihydrouridine synthase 1 like [ Mus musculus (house mouse) ]

    Gene ID: 68730, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dus1lprovided by MGI
    Official Full Name
    dihydrouridine synthase 1 likeprovided by MGI
    Primary source
    MGI:MGI:1915980
    See related
    Ensembl:ENSMUSG00000025155 AllianceGenome:MGI:1915980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110032N12Rik
    Summary
    Predicted to enable tRNA dihydrouridine synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. Orthologous to human DUS1L (dihydrouridine synthase 1 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 37.4), testis adult (RPKM 31.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dus1l in Genome Data Viewer
    Location:
    11 E2; 11 84.54 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120678385..120687254, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120787559..120796427, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31367 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120637476-120637735 Neighboring gene NADPH-dependent carbonyl reductase pseudogene Neighboring gene STARR-seq mESC enhancer starr_31368 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120657732-120657915 Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene G protein pathway suppressor 1 Neighboring gene fatty acid synthase Neighboring gene STARR-positive B cell enhancer ABC_E9039 Neighboring gene coiled-coil domain containing 57 Neighboring gene STARR-seq mESC enhancer starr_31373 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120794121-120794304

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-dihydrouridine16 synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-dihydrouridine17 synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA dihydrouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA dihydrouridine synthesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
    NP_001404854.1
    NP_001404855.1
    NP_001404856.1
    NP_001404857.1
    NP_001404858.1
    NP_001404859.1
    NP_081100.2
    XP_011247517.1
    XP_011247518.1
    XP_017170221.1
    XP_036012830.1
    XP_036012833.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417925.1 → NP_001404854.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL663090
      UniProtKB/Swiss-Prot
      Q8C2P3, Q8VCN7, Q9D124
      Related
      ENSMUSP00000101741.2, ENSMUST00000106135.8

    2. NM_001417926.1 → NP_001404855.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL663090

    3. NM_001417927.1 → NP_001404856.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL663090
      UniProtKB/Swiss-Prot
      Q8C2P3, Q8VCN7, Q9D124

    4. NM_001417928.1 → NP_001404857.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL663090
      UniProtKB/Swiss-Prot
      Q8C2P3, Q8VCN7, Q9D124

    5. NM_001417929.1 → NP_001404858.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL663090

    6. NM_001417930.1 → NP_001404859.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL663090

    7. NM_026824.5 → NP_081100.2  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

      See identical proteins and their annotated locations for NP_081100.2

      Status: VALIDATED

      Source sequence(s)
      AL663090
      Consensus CDS
      CCDS49012.1
      UniProtKB/Swiss-Prot
      Q8C2P3, Q8VCN7, Q9D124
      UniProtKB/TrEMBL
      B1ATU5
      Related
      ENSMUSP00000132516.2, ENSMUST00000167023.8
      Conserved Domains (2) summary
      TIGR01623
      Location:396 → 431
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cd02801
      Location:18 → 250
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

    RNA

    1. NR_184653.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL663090

    2. NR_184654.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL663090

    3. NR_184655.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL663090

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120678385..120687254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156937.1 → XP_036012830.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X4

      UniProtKB/TrEMBL
      B1ATU5
      Conserved Domains (2) summary
      TIGR01623
      Location:379 → 414
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cd02801
      Location:18 → 233
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

    2. XM_011249215.4 → XP_011247517.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X3

      UniProtKB/TrEMBL
      B1ATU5
      Conserved Domains (2) summary
      TIGR01623
      Location:395 → 430
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cd02801
      Location:34 → 249
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

    3. XM_036156940.1 → XP_036012833.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

      Conserved Domains (3) summary
      TIGR01623
      Location:212 → 247
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cl21457
      Location:3 → 66
      TIM; TIM-like beta/alpha barrel domains
      cl40685
      Location:3 → 132
      DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]

    4. XM_011249216.3 → XP_011247518.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

      See identical proteins and their annotated locations for XP_011247518.1

      Conserved Domains (3) summary
      TIGR01623
      Location:212 → 247
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cl21457
      Location:3 → 66
      TIM; TIM-like beta/alpha barrel domains
      cl40685
      Location:3 → 132
      DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]

    5. XM_017314732.3 → XP_017170221.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

      UniProtKB/TrEMBL
      B1ATU5
      Conserved Domains (2) summary
      TIGR01623
      Location:412 → 447
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cd02801
      Location:34 → 266
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C2P3.1 GenPept UniProtKB/Swiss-Prot:Q8C2P3

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