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    MIOX myo-inositol oxygenase [ Homo sapiens (human) ]

    Gene ID: 55586, updated on 2-Nov-2024

    Summary

    Official Symbol
    MIOXprovided by HGNC
    Official Full Name
    myo-inositol oxygenaseprovided by HGNC
    Primary source
    HGNC:HGNC:14522
    See related
    Ensembl:ENSG00000100253 MIM:606774; AllianceGenome:HGNC:14522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALDRL6
    Summary
    Enables ferric iron binding activity and inositol oxygenase activity. Involved in inositol catabolic process. Predicted to be located in cytoplasm and inclusion body. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward kidney (RPKM 162.3) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MIOX in Genome Data Viewer
    Location:
    22q13.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50486859..50490648)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50996041..50999830)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50925288..50929077)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50883030-50883876 Neighboring gene SET binding factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50910985-50911896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50911897-50912806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50913717-50914626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13982 Neighboring gene adrenomedullin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50955745-50956678 Neighboring gene lipase maturation factor 2 Neighboring gene non-SMC condensin II complex subunit H2 Neighboring gene synthesis of cytochrome C oxidase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC90217

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ferric iron binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol oxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol oxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol oxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in inositol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inositol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inositol catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in inclusion body ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    inositol oxygenase
    Names
    MI oxygenase
    aldehyde reductase (aldose reductase) like 6
    aldehyde reductase-like 6
    kidney-specific protein 32
    renal-specific oxidoreductase
    NP_060054.4
    XP_005261982.1
    XP_011529007.1
    XP_047297399.1
    XP_054181762.1
    XP_054181763.1
    XP_054181764.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017584.6NP_060054.4  inositol oxygenase

      See identical proteins and their annotated locations for NP_060054.4

      Status: VALIDATED

      Source sequence(s)
      AF197129, AL096767, BC012025, BC064395
      Consensus CDS
      CCDS14092.1
      UniProtKB/Swiss-Prot
      Q05DJ6, Q5S8C9, Q9BZZ1, Q9UGB7, Q9UHB8
      UniProtKB/TrEMBL
      A6PVH4
      Related
      ENSP00000216075.6, ENST00000216075.11
      Conserved Domains (1) summary
      pfam05153
      Location:37285
      MIOX; Myo-inositol oxygenase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      50486859..50490648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441443.1XP_047297399.1  inositol oxygenase isoform X3

      Related
      ENSP00000379082.3, ENST00000395733.7
    2. XM_011530705.3XP_011529007.1  inositol oxygenase isoform X2

      Conserved Domains (1) summary
      pfam05153
      Location:37113
      MIOX; Myo-inositol oxygenase
    3. XM_005261925.5XP_005261982.1  inositol oxygenase isoform X1

      UniProtKB/TrEMBL
      A6PVH4
      Conserved Domains (1) summary
      pfam05153
      Location:1239
      MIOX; Myo-inositol oxygenase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      50996041..50999830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325789.1XP_054181764.1  inositol oxygenase isoform X3

    2. XM_054325788.1XP_054181763.1  inositol oxygenase isoform X2

    3. XM_054325787.1XP_054181762.1  inositol oxygenase isoform X1