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    ZNF618 zinc finger protein 618 [ Homo sapiens (human) ]

    Gene ID: 114991, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ZNF618provided by HGNC
    Official Full Name
    zinc finger protein 618provided by HGNC
    Primary source
    HGNC:HGNC:29416
    See related
    Ensembl:ENSG00000157657 MIM:617077; AllianceGenome:HGNC:29416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEDD10; FP13169
    Summary
    Enables identical protein binding activity and transcription coregulator binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in pericentric heterochromatin. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 1.9), kidney (RPKM 1.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF618 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113876309..114056593)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (126074898..126255263)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116638589..116818873)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene KIAA1586 pseudogene Neighboring gene programmed cell death 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116636012-116636512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116636513-116637013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116697421-116697921 Neighboring gene VISTA enhancer hs641 Neighboring gene Sharpr-MPRA regulatory region 15709 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:116751538-116752038 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:116768395-116768894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116770304-116770804 Neighboring gene uncharacterized LOC107987120 Neighboring gene alpha-1-microglobulin/bikunin precursor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader. Liu Y, et al. J Biol Chem, 2016 Jun 24. PMID 27129234, Free PMC Article
    2. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. Letra A, et al. Am J Med Genet A, 2010 Jul. PMID 20583170, Free PMC Article
    3. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. Yoshida T, et al. Int J Mol Med, 2009 Oct. PMID 19724895
    4. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. Nagase T, et al. DNA Res, 2001 Dec 31. PMID 11853319
    5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. Oguri M, et al. Am J Hypertens, 2010 Jan. PMID 19851296

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study suggests that ZNF618 is a key protein that regulates UHRF2 function as a specific 5hmC reader in vivo.
      Title: Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 618
    Names
    neural precursor cell expressed, developmentally down-regulated 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318040.2 → NP_001304969.1  zinc finger protein 618 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is longer than isoform 1.
      Source sequence(s)
      AJ420454, AL137850, BC036039, BC136287
      Consensus CDS
      CCDS83403.1
      UniProtKB/Swiss-Prot
      Q5T7W0
      Related
      ENSP00000483198.1, ENST00000615615.4
      Conserved Domains (2) summary
      pfam09595
      Location:250 → 358
      Metaviral_G; Metaviral_G glycoprotein
      sd00017
      Location:117 → 137
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001318041.2 → NP_001304970.1  zinc finger protein 618 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is longer than isoform 1.
      Source sequence(s)
      AJ420454, AL137850, BC036039, BC143826
      UniProtKB/Swiss-Prot
      Q5T7W0
      Conserved Domains (2) summary
      pfam09595
      Location:250 → 359
      Metaviral_G; Metaviral_G glycoprotein
      sd00017
      Location:117 → 137
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001318042.2 → NP_001304971.1  zinc finger protein 618 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is longer than isoform 1.
      Source sequence(s)
      AJ420454, AL137850, BC036039
      Consensus CDS
      CCDS83402.1
      UniProtKB/Swiss-Prot
      B9EG82, Q4G0X6, Q5T7W0, Q5T7W1, Q6ZT53, Q7Z6B9, Q8TF49, Q96E49
      Related
      ENSP00000363241.5, ENST00000374126.10
      Conserved Domains (2) summary
      pfam09595
      Location:282 → 391
      Metaviral_G; Metaviral_G glycoprotein
      sd00017
      Location:149 → 169
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_133374.3 → NP_588615.2  zinc finger protein 618 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1).
      Source sequence(s)
      AJ420454, AL137850, BC053892, BI463128
      Consensus CDS
      CCDS48008.1
      UniProtKB/Swiss-Prot
      Q5T7W0
      Related
      ENSP00000288466.7, ENST00000288466.11
      Conserved Domains (2) summary
      COG5189
      Location:107 → 175
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:117 → 137
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      113876309..114056593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005251692.4 → XP_005251749.1  zinc finger protein 618 isoform X1

      Conserved Domains (1) summary
      sd00017
      Location:149 → 169
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_017014242.3 → XP_016869731.1  zinc finger protein 618 isoform X4

    3. XM_017014241.3 → XP_016869730.1  zinc finger protein 618 isoform X2

    4. XM_017014243.3 → XP_016869732.1  zinc finger protein 618 isoform X5

    5. XM_017014248.3 → XP_016869737.1  zinc finger protein 618 isoform X26

    6. XM_047422732.1 → XP_047278688.1  zinc finger protein 618 isoform X29

    7. XM_017014249.3 → XP_016869738.1  zinc finger protein 618 isoform X27

    8. XM_017014250.3 → XP_016869739.1  zinc finger protein 618 isoform X30

    9. XM_011518201.3 → XP_011516503.1  zinc finger protein 618 isoform X6

      Conserved Domains (1) summary
      sd00017
      Location:149 → 169
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. XM_047422717.1 → XP_047278673.1  zinc finger protein 618 isoform X7

    11. XM_017014244.3 → XP_016869733.1  zinc finger protein 618 isoform X13

    12. XM_017014252.3 → XP_016869741.1  zinc finger protein 618 isoform X34

      Conserved Domains (1) summary
      sd00017
      Location:149 → 169
      ZF_C2H2; C2H2 Zn finger [structural motif]

    13. XM_047422733.1 → XP_047278689.1  zinc finger protein 618 isoform X31

    14. XM_005251699.4 → XP_005251756.1  zinc finger protein 618 isoform X35

      Conserved Domains (1) summary
      sd00017
      Location:149 → 169
      ZF_C2H2; C2H2 Zn finger [structural motif]

    15. XM_011518200.3 → XP_011516502.1  zinc finger protein 618 isoform X3

      Conserved Domains (1) summary
      sd00017
      Location:149 → 169
      ZF_C2H2; C2H2 Zn finger [structural motif]

    16. XM_047422718.1 → XP_047278674.1  zinc finger protein 618 isoform X8

    17. XM_047422719.1 → XP_047278675.1  zinc finger protein 618 isoform X9

    18. XM_047422731.1 → XP_047278687.1  zinc finger protein 618 isoform X28

    19. XM_047422720.1 → XP_047278676.1  zinc finger protein 618 isoform X11

    20. XM_047422723.1 → XP_047278679.1  zinc finger protein 618 isoform X16

    21. XM_047422738.1 → XP_047278694.1  zinc finger protein 618 isoform X38

    22. XM_011518203.4 → XP_011516505.1  zinc finger protein 618 isoform X10

      Conserved Domains (1) summary
      sd00017
      Location:117 → 137
      ZF_C2H2; C2H2 Zn finger [structural motif]

    23. XM_017014245.3 → XP_016869734.1  zinc finger protein 618 isoform X15

    24. XM_047422721.1 → XP_047278677.1  zinc finger protein 618 isoform X12

    25. XM_017014246.3 → XP_016869735.1  zinc finger protein 618 isoform X17

    26. XM_047422734.1 → XP_047278690.1  zinc finger protein 618 isoform X32

    27. XM_047422737.1 → XP_047278693.1  zinc finger protein 618 isoform X37

    28. XM_047422735.1 → XP_047278691.1  zinc finger protein 618 isoform X33

    29. XM_011518204.4 → XP_011516506.1  zinc finger protein 618 isoform X18

      Conserved Domains (1) summary
      sd00017
      Location:117 → 137
      ZF_C2H2; C2H2 Zn finger [structural motif]

    30. XM_047422724.1 → XP_047278680.1  zinc finger protein 618 isoform X19

    31. XM_047422739.1 → XP_047278695.1  zinc finger protein 618 isoform X39

    32. XM_047422745.1 → XP_047278701.1  zinc finger protein 618 isoform X45

    33. XM_047422740.1 → XP_047278696.1  zinc finger protein 618 isoform X40

    34. XM_047422746.1 → XP_047278702.1  zinc finger protein 618 isoform X46

    35. XM_047422722.1 → XP_047278678.1  zinc finger protein 618 isoform X14

    36. XM_047422725.1 → XP_047278681.1  zinc finger protein 618 isoform X20

    37. XM_047422726.1 → XP_047278682.1  zinc finger protein 618 isoform X21

    38. XM_047422741.1 → XP_047278697.1  zinc finger protein 618 isoform X41

    39. XM_047422736.1 → XP_047278692.1  zinc finger protein 618 isoform X36

    40. XM_047422742.1 → XP_047278698.1  zinc finger protein 618 isoform X42

    41. XM_047422727.1 → XP_047278683.1  zinc finger protein 618 isoform X22

    42. XM_047422729.1 → XP_047278685.1  zinc finger protein 618 isoform X24

    43. XM_047422728.1 → XP_047278684.1  zinc finger protein 618 isoform X23

    44. XM_047422730.1 → XP_047278686.1  zinc finger protein 618 isoform X25

    45. XM_047422743.1 → XP_047278699.1  zinc finger protein 618 isoform X43

    46. XM_047422744.1 → XP_047278700.1  zinc finger protein 618 isoform X44

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      126074898..126255263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361896.1 → XP_054217871.1  zinc finger protein 618 isoform X1

    2. XM_054361899.1 → XP_054217874.1  zinc finger protein 618 isoform X4

    3. XM_054361897.1 → XP_054217872.1  zinc finger protein 618 isoform X2

    4. XM_054361900.1 → XP_054217875.1  zinc finger protein 618 isoform X5

    5. XM_054361921.1 → XP_054217896.1  zinc finger protein 618 isoform X26

    6. XM_054361924.1 → XP_054217899.1  zinc finger protein 618 isoform X29

    7. XM_054361922.1 → XP_054217897.1  zinc finger protein 618 isoform X27

    8. XM_054361925.1 → XP_054217900.1  zinc finger protein 618 isoform X30

    9. XM_054361901.1 → XP_054217876.1  zinc finger protein 618 isoform X6

    10. XM_054361902.1 → XP_054217877.1  zinc finger protein 618 isoform X7

    11. XM_054361908.1 → XP_054217883.1  zinc finger protein 618 isoform X13

    12. XM_054361929.1 → XP_054217904.1  zinc finger protein 618 isoform X34

    13. XM_054361926.1 → XP_054217901.1  zinc finger protein 618 isoform X31

    14. XM_054361930.1 → XP_054217905.1  zinc finger protein 618 isoform X35

    15. XM_054361898.1 → XP_054217873.1  zinc finger protein 618 isoform X3

    16. XM_054361903.1 → XP_054217878.1  zinc finger protein 618 isoform X8

    17. XM_054361904.1 → XP_054217879.1  zinc finger protein 618 isoform X9

    18. XM_054361923.1 → XP_054217898.1  zinc finger protein 618 isoform X28

    19. XM_054361906.1 → XP_054217881.1  zinc finger protein 618 isoform X11

    20. XM_054361911.1 → XP_054217886.1  zinc finger protein 618 isoform X16

    21. XM_054361933.1 → XP_054217908.1  zinc finger protein 618 isoform X38

    22. XM_054361905.1 → XP_054217880.1  zinc finger protein 618 isoform X10

    23. XM_054361910.1 → XP_054217885.1  zinc finger protein 618 isoform X15

    24. XM_054361907.1 → XP_054217882.1  zinc finger protein 618 isoform X12

    25. XM_054361912.1 → XP_054217887.1  zinc finger protein 618 isoform X17

    26. XM_054361927.1 → XP_054217902.1  zinc finger protein 618 isoform X32

    27. XM_054361932.1 → XP_054217907.1  zinc finger protein 618 isoform X37

    28. XM_054361928.1 → XP_054217903.1  zinc finger protein 618 isoform X33

    29. XM_054361913.1 → XP_054217888.1  zinc finger protein 618 isoform X18

    30. XM_054361914.1 → XP_054217889.1  zinc finger protein 618 isoform X19

    31. XM_054361934.1 → XP_054217909.1  zinc finger protein 618 isoform X39

    32. XM_054361940.1 → XP_054217915.1  zinc finger protein 618 isoform X45

    33. XM_054361935.1 → XP_054217910.1  zinc finger protein 618 isoform X40

    34. XM_054361941.1 → XP_054217916.1  zinc finger protein 618 isoform X46

    35. XM_054361909.1 → XP_054217884.1  zinc finger protein 618 isoform X14

    36. XM_054361915.1 → XP_054217890.1  zinc finger protein 618 isoform X20

    37. XM_054361916.1 → XP_054217891.1  zinc finger protein 618 isoform X21

    38. XM_054361936.1 → XP_054217911.1  zinc finger protein 618 isoform X41

    39. XM_054361931.1 → XP_054217906.1  zinc finger protein 618 isoform X36

    40. XM_054361937.1 → XP_054217912.1  zinc finger protein 618 isoform X42

    41. XM_054361917.1 → XP_054217892.1  zinc finger protein 618 isoform X22

    42. XM_054361919.1 → XP_054217894.1  zinc finger protein 618 isoform X24

    43. XM_054361918.1 → XP_054217893.1  zinc finger protein 618 isoform X23

    44. XM_054361920.1 → XP_054217895.1  zinc finger protein 618 isoform X25

    45. XM_054361938.1 → XP_054217913.1  zinc finger protein 618 isoform X43

    46. XM_054361939.1 → XP_054217914.1  zinc finger protein 618 isoform X44

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001040063.1: Suppressed sequence

      Description
      NM_001040063.1: This RefSeq was permanently suppressed because it was primarily UTR sequence.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T7W0.1 GenPept UniProtKB/Swiss-Prot:Q5T7W0

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