CTNND1 catenin delta 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CTNND1provided by HGNC
Official Full Name: catenin delta 1provided by HGNC
Primary source: HGNC:HGNC:2515
See related: Ensembl:ENSG00000198561 MIM:601045; AllianceGenome:HGNC:2515
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAS; p120; BCDS2; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN)
Summary: This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]
Expression: Ubiquitous expression in esophagus (RPKM 79.1), skin (RPKM 62.3) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q12.1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (57761802..57819540)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (57712138..57769885)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (57529274..57587012)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions.
Title: CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions.
Tag, you're it: G-ICAT identifies p120-cysteine glutathionylation triggering E-cadherin destabilization.
Title: Tag, you're it: G-ICAT identifies p120-cysteine glutathionylation triggering E-cadherin destabilization.
The E3 ubiquitin ligase MIB1 suppresses breast cancer cell migration through regulating CTNND1 protein level.
Title: The E3 ubiquitin ligase MIB1 suppresses breast cancer cell migration through regulating CTNND1 protein level.
p120 regulates E-cadherin expression in nasal epithelial cells in chronic rhinosinusitis.
Title: p120 regulates E-cadherin expression in nasal epithelial cells in chronic rhinosinusitis.
CTNND1 variants cause familial exudative vitreoretinopathy through the Wnt/cadherin axis.
Title: CTNND1 variants cause familial exudative vitreoretinopathy through the Wnt/cadherin axis.
Downregulated circular RNA hsa_circ_0005797 inhibits endometrial cancer by modulating microRNA-298/Catenin delta 1 signaling.
Title: Downregulated circular RNA hsa_circ_0005797 inhibits endometrial cancer by modulating microRNA-298/Catenin delta 1 signaling.
Nuclear p120 catenin is a component of the perichromosomal layer and coordinates sister chromatid segregation during mitosis in lung cancer cells.
Title: Nuclear p120 catenin is a component of the perichromosomal layer and coordinates sister chromatid segregation during mitosis in lung cancer cells.
Cytoplasmic P120ctn Promotes Gefitinib Resistance in Lung Cancer Cells by Activating PAK1 and ERK Pathway.
Title: Cytoplasmic P120ctn Promotes Gefitinib Resistance in Lung Cancer Cells by Activating PAK1 and ERK Pathway.
p-120 Catenin is a Useful Diagnostic Biomarker for Distinguishing Plasmacytoid and Sarcomatoid Variants From Conventional Urothelial Carcinoma.
Title: p-120 Catenin is a Useful Diagnostic Biomarker for Distinguishing Plasmacytoid and Sarcomatoid Variants From Conventional Urothelial Carcinoma.
PLEKHA7, an Apical Adherens Junction Protein, Suppresses Inflammatory Breast Cancer in the Context of High E-Cadherin and p120-Catenin Expression.
Title: PLEKHA7, an Apical Adherens Junction Protein, Suppresses Inflammatory Breast Cancer in the Context of High E-Cadherin and p120-Catenin Expression.

Submit: New GeneRIF Correction See all GeneRIFs (187)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Blepharocheilodontic syndrome 2 MedGen: C4540127 OMIM: 617681 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S4004 (e-PCR)
- UniSTS:19071

GDB:451855 (e-PCR)
- UniSTS:157384

RH47458 (e-PCR)
- UniSTS:51418

STS-H97485 (e-PCR)
- UniSTS:63219

Readthrough TMX2-CTNND1

Readthrough gene: TMX2-CTNND1, Included gene: TMX2

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	HDA more info	PubMed
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IDA Inferred from Direct Assay more info	PubMed
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein sequestering activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
part_of catenin complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in hippocampal mossy fiber to CA3 synapse	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density, intracellular component	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone cytoplasmic component	IEA Inferred from Electronic Annotation more info
located_in zonula adherens	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: catenin delta-1

Names: cadherin-associated Src substrate; catenin (cadherin-associated protein), delta 1; p120 catenin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029078.2 RefSeqGene

Range

5002..62740

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001085458.2 → NP_001078927.1 catenin delta-1 isoform 1ABC

See identical proteins and their annotated locations for NP_001078927.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the longest variant and it encodes the longest protein (isoform 1ABC). This variant has also been called hp120ctn-1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS44604.1

UniProtKB/Swiss-Prot

A8K939, O15088, O60713, O60714, O60715, O60716, O60935, Q6DHZ7, Q6RBX8, Q9UP71, Q9UP72, Q9UP73

UniProtKB/TrEMBL

C9JZR2, E9PN49

Related

ENSP00000382004.5, ENST00000399050.10

Conserved Domains (2) summary

cd00020
Location:363 → 481

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:368 → 393

ARM; armadillo repeat [structural motif]
NM_001085459.2 → NP_001078928.1 catenin delta-1 isoform 1AB

See identical proteins and their annotated locations for NP_001078928.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment in the coding region, compared to variant 1. The resulting protein (isoform 1AB) is shorter than isoform 1ABC. This variant is also called hp120ctn-1AB.

Source sequence(s)

AP001931

Consensus CDS

CCDS44605.1

UniProtKB/TrEMBL

C9JZR2, E9PN49

Related

ENSP00000354823.4, ENST00000361332.8

Conserved Domains (2) summary

cd00020
Location:363 → 481

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:368 → 393

ARM; armadillo repeat [structural motif]
NM_001085460.2 → NP_001078929.1 catenin delta-1 isoform 1A

See identical proteins and their annotated locations for NP_001078929.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses a different splice site in the 5' UTR and lacks two alternate in-frame segments in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-1A with variants 5 and 6. Variants 4, 5, and 6 encode the same protein (isoform 1A), which is shorter than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS44606.1

UniProtKB/TrEMBL

C9JZR2, E9PN49

Related

ENSP00000351527.6, ENST00000358694.10

Conserved Domains (2) summary

cd00020
Location:363 → 481

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:368 → 393

ARM; armadillo repeat [structural motif]
NM_001085461.2 → NP_001078930.1 catenin delta-1 isoform 1A

See identical proteins and their annotated locations for NP_001078930.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two alternate in-frame segments in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-1A with variants 4 and 6. Variants 4, 5, and 6 encode the same protein (isoform 1A), which is shorter than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS44606.1

UniProtKB/TrEMBL

C9JZR2, E9PN49

Related

ENSP00000500962.1, ENST00000673683.1

Conserved Domains (2) summary

cd00020
Location:363 → 481

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:368 → 393

ARM; armadillo repeat [structural motif]
NM_001085462.2 → NP_001078931.1 catenin delta-1 isoform 1A

See identical proteins and their annotated locations for NP_001078931.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses a different splice site in the 5' UTR, lacks an alternate segment in the 5' UTR, and lacks two alternate in-frame segments in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-1A with variants 4 and 5. Variants 4, 5, and 6 encode the same protein (isoform 1A), which is shorter than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS44606.1

UniProtKB/TrEMBL

C9JZR2, E9PN49

Related

ENSP00000413586.2, ENST00000428599.6

Conserved Domains (2) summary

cd00020
Location:363 → 481

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:368 → 393

ARM; armadillo repeat [structural motif]
NM_001085463.2 → NP_001078932.1 catenin delta-1 isoform 3ABC

See identical proteins and their annotated locations for NP_001078932.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) has multiple differences and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3ABC) has a shorter N-terminus, compared to isoform 1ABC. This variant is also called hp120ctn-3ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS44608.1

UniProtKB/TrEMBL

Q96FS1

Related

ENSP00000403518.2, ENST00000415361.6

Conserved Domains (2) summary

cd00020
Location:262 → 380

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:267 → 292

ARM; armadillo repeat [structural motif]
NM_001085464.2 → NP_001078933.1 catenin delta-1 isoform 3AB

See identical proteins and their annotated locations for NP_001078933.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) has multiple differences and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3AB) has a shorter N-terminus, compared to isoform 1ABC. This variant is also called hp120ctn-3AB.

Source sequence(s)

AP001931

Consensus CDS

CCDS53633.1

UniProtKB/TrEMBL

Q96FS1

Related

ENSP00000437327.1, ENST00000530094.5

Conserved Domains (2) summary

cd00020
Location:262 → 380

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:267 → 292

ARM; armadillo repeat [structural motif]
NM_001085465.2 → NP_001078934.1 catenin delta-1 isoform 3B

See identical proteins and their annotated locations for NP_001078934.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) has multiple differences and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3B) is shorter when it is compared to isoform 1ABC. This variant is also called hp120ctn-3B.

Source sequence(s)

AP001931

Consensus CDS

CCDS53634.1

UniProtKB/TrEMBL

Q96FS1

Related

ENSP00000434949.1, ENST00000532787.5

Conserved Domains (2) summary

cd00020
Location:262 → 380

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:267 → 292

ARM; armadillo repeat [structural motif]
NM_001085466.2 → NP_001078935.1 catenin delta-1 isoform 3AC

See identical proteins and their annotated locations for NP_001078935.1

Status: REVIEWED

Description

Transcript Variant: This variant (10) has multiple differences, compared to variant 1. The resulting protein (isoform 3AC) is shorter than isoform 1ABC. This variant is also called hp120ctn-3AC.

Source sequence(s)

AP001931

Consensus CDS

CCDS53632.1

UniProtKB/TrEMBL

Q96FS1

Related

ENSP00000435266.1, ENST00000528232.5

Conserved Domains (2) summary

cd00020
Location:262 → 380

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:267 → 292

ARM; armadillo repeat [structural motif]
NM_001085467.2 → NP_001078936.1 catenin delta-1 isoform 3A

See identical proteins and their annotated locations for NP_001078936.1

Status: REVIEWED

Description

Transcript Variant: This variant (11) lacks multiple alternate segments in the 5' UTR and in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-3A with variants 12 and 13. Variants 11, 12, and 13 encode the same protein (isoform 3A), which is shorter than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS44609.1

UniProtKB/TrEMBL

Q96FS1

Related

ENSP00000409930.2, ENST00000426142.6

Conserved Domains (2) summary

cd00020
Location:262 → 380

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:267 → 292

ARM; armadillo repeat [structural motif]
NM_001085468.2 → NP_001078937.1 catenin delta-1 isoform 3A

See identical proteins and their annotated locations for NP_001078937.1

Status: REVIEWED

Description

Transcript Variant: This variant (12) lacks multiple alternate segments in the 5' UTR and in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-3A with variants 11 and 13. Variants 11, 12, and 13 encode the same protein (isoform 3A), which is shorter than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS44609.1

UniProtKB/TrEMBL

Q96FS1

Related

ENSP00000437156.1, ENST00000529986.5

Conserved Domains (2) summary

cd00020
Location:262 → 380

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:267 → 292

ARM; armadillo repeat [structural motif]
NM_001085469.2 → NP_001078938.1 catenin delta-1 isoform 3A

See identical proteins and their annotated locations for NP_001078938.1

Status: REVIEWED

Description

Transcript Variant: This variant (13) lacks multiple alternate segments in the 5' UTR and in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-3A with variants 11 and 12. Variants 11, 12, and 13 encode the same protein (isoform 3A), which is shorter than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS44609.1

UniProtKB/TrEMBL

Q96FS1

Related

ENSP00000434017.1, ENST00000532245.5

Conserved Domains (2) summary

cd00020
Location:262 → 380

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:267 → 292

ARM; armadillo repeat [structural motif]
NM_001206883.2 → NP_001193812.1 catenin delta-1 isoform 2ABC

See identical proteins and their annotated locations for NP_001193812.1

Status: REVIEWED

Description

Transcript Variant: This variant (14) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2ABC) has a shorter N-terminus than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS55763.1

UniProtKB/TrEMBL

C9JZR2, E9PN49

Related

ENSP00000433276.1, ENST00000532844.5

Conserved Domains (2) summary

cd00020
Location:309 → 427

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:314 → 339

ARM; armadillo repeat [structural motif]
NM_001206884.2 → NP_001193813.1 catenin delta-1 isoform 2AC

See identical proteins and their annotated locations for NP_001193813.1

Status: REVIEWED

Description

Transcript Variant: This variant (15) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2AC) is shorter than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS55764.1

UniProtKB/TrEMBL

C9JZR2, E9PN49

Related

ENSP00000436744.1, ENST00000530748.5

Conserved Domains (2) summary

cd00020
Location:309 → 427

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:314 → 339

ARM; armadillo repeat [structural motif]
NM_001206885.2 → NP_001193814.1 catenin delta-1 isoform 1AC

See identical proteins and their annotated locations for NP_001193814.1

Status: REVIEWED

Description

Transcript Variant: This variant (16) lacks an in-frame exon in the 3_ coding region, compared to variant 1. This results in a shorter protein (isoform 1AC), compared to isoform 1ABC).

Source sequence(s)

AP001931

Consensus CDS

CCDS73290.1

UniProtKB/TrEMBL

C9JZR2, E9PN49

Related

ENSP00000354907.5, ENST00000361796.9

Conserved Domains (2) summary

cd00020
Location:363 → 481

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:368 → 393

ARM; armadillo repeat [structural motif]
NM_001206886.2 → NP_001193815.1 catenin delta-1 isoform 2AB

See identical proteins and their annotated locations for NP_001193815.1

Status: REVIEWED

Description

Transcript Variant: This variant (17) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2AB) is shorter than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS55765.1

UniProtKB/TrEMBL

Q96FS1

Related

ENSP00000433334.1, ENST00000526357.5

Conserved Domains (2) summary

cd00020
Location:309 → 427

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:314 → 339

ARM; armadillo repeat [structural motif]
NM_001206887.2 → NP_001193816.1 catenin delta-1 isoform 2B

See identical proteins and their annotated locations for NP_001193816.1

Status: REVIEWED

Description

Transcript Variant: This variant (18) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2B) is shorter than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS55767.1

UniProtKB/TrEMBL

Q96FS1

Related

ENSP00000435494.1, ENST00000529873.5

Conserved Domains (2) summary

cd00020
Location:309 → 427

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:314 → 339

ARM; armadillo repeat [structural motif]
NM_001206888.2 → NP_001193817.1 catenin delta-1 isoform 2A

See identical proteins and their annotated locations for NP_001193817.1

Status: REVIEWED

Description

Transcript Variant: This variant (19) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2A) is shorter than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS55766.1

UniProtKB/TrEMBL

Q96FS1

Related

ENSP00000432243.1, ENST00000528621.5

Conserved Domains (2) summary

cd00020
Location:309 → 427

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:314 → 339

ARM; armadillo repeat [structural motif]
NM_001206889.2 → NP_001193818.1 catenin delta-1 isoform 2A

See identical proteins and their annotated locations for NP_001193818.1

Status: REVIEWED

Description

Transcript Variant: This variant (20) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2A) is shorter than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS55766.1

UniProtKB/TrEMBL

Q96FS1

Related

ENSP00000435379.1, ENST00000532649.5

Conserved Domains (2) summary

cd00020
Location:309 → 427

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:314 → 339

ARM; armadillo repeat [structural motif]
NM_001206890.2 → NP_001193819.1 catenin delta-1 isoform 3A

See identical proteins and their annotated locations for NP_001193819.1

Status: REVIEWED

Description

Transcript Variant: This variant (21) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (3A) is shorter than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS44609.1

UniProtKB/TrEMBL

Q96FS1

Related

ENSP00000432075.1, ENST00000532463.5

Conserved Domains (2) summary

cd00020
Location:262 → 380

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:267 → 292

ARM; armadillo repeat [structural motif]
NM_001206891.2 → NP_001193820.1 catenin delta-1 isoform 2A

See identical proteins and their annotated locations for NP_001193820.1

Status: REVIEWED

Description

Transcript Variant: This variant (22) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2A) is shorter than isoform 1ABC.

Source sequence(s)

AP001931

Consensus CDS

CCDS55766.1

UniProtKB/TrEMBL

Q96FS1

Related

ENSP00000436323.1, ENST00000529526.5

Conserved Domains (2) summary

cd00020
Location:309 → 427

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:314 → 339

ARM; armadillo repeat [structural motif]
NM_001331.3 → NP_001322.1 catenin delta-1 isoform 1B

See identical proteins and their annotated locations for NP_001322.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame segments in the coding region, compared to variant 1. The encoded protein (isoform 1B) is shorter than isoform 1ABC. Another name for this variant is hp120ctn-1B.

Source sequence(s)

AP001931

Consensus CDS

CCDS44607.1

UniProtKB/TrEMBL

A0A669KB62

Related

ENSP00000354785.6, ENST00000361391.10

Conserved Domains (2) summary

cd00020
Location:363 → 481

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:368 → 393

ARM; armadillo repeat [structural motif]