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    GSN gelsolin [ Homo sapiens (human) ]

    Gene ID: 2934, updated on 3-Nov-2024

    Summary

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    Official Symbol
    GSNprovided by HGNC
    Official Full Name
    gelsolinprovided by HGNC
    Primary source
    HGNC:HGNC:4620
    See related
    Ensembl:ENSG00000148180 MIM:137350; AllianceGenome:HGNC:4620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADF; AGEL; AMYLD4
    Summary
    The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 444.2), heart (RPKM 172.6) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GSN in Genome Data Viewer
    Location:
    9q33.2
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (121201483..121332842)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (133397510..133528852)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (123963761..124095120)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene complement C5 Neighboring gene uncharacterized LOC124902261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28914 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:123836497-123836693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28917 Neighboring gene NANOG hESC enhancer GRCh37_chr9:123883693-123884194 Neighboring gene centriolin Neighboring gene uncharacterized LOC124902357 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20231 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:123963761-123964260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28920 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:123983210-123983860 Neighboring gene RNA, 7SL, cytoplasmic 181, pseudogene Neighboring gene RAB14, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28921 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124023585-124024084 Neighboring gene ATPase H+ transporting V1 subunit B2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20233 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:124043752-124044951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124047035-124047535 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:124048350-124049549 Neighboring gene Sharpr-MPRA regulatory region 178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124056667-124057289 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124061747-124062407 Neighboring gene GSN antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124089303-124090216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28922 Neighboring gene uncharacterized LOC102723324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124132533-124133493 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:124148517-124149463 Neighboring gene stomatin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124215525-124216026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124216027-124216526 Neighboring gene NANOG hESC enhancer GRCh37_chr9:124234601-124235163 Neighboring gene glycoprotein alpha-galactosyltransferase 1 (inactive) Neighboring gene RNA, 7SL, cytoplasmic 187, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Multifunctional roles of gelsolin in health and diseases. Li GH, et al. Med Res Rev, 2012 Sep. PMID 22886630
    2. Inactivation of endotoxin by human plasma gelsolin. Bucki R, et al. Biochemistry, 2005 Jul 19. PMID 16008344
    3. Gelsolin affects the migratory ability of human colon adenocarcinoma and melanoma cells. Litwin M, et al. Life Sci, 2012 Jun 6. PMID 22552326
    4. Functional characterization of alternatively spliced GSN in head and neck squamous cell carcinoma. Kelley DZ, et al. Transl Res, 2018 Dec. PMID 30118659, Free PMC Article
    5. ATP competes with PIP2 for binding to gelsolin. Szatmári D, et al. PLoS One, 2018. PMID 30086165, Free PMC Article

    See all (362) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteomic Analysis Identifies GSN as a Noninvasive Circulating Serum Biomarker for Predicting Early Recurrence of Hepatocellular Carcinoma.
      Title: Proteomic Analysis Identifies GSN as a Noninvasive Circulating Serum Biomarker for Predicting Early Recurrence of Hepatocellular Carcinoma.
    2. The regulation of plasma gelsolin by DNA methylation in ovarian cancer chemo-resistance.
      Title: The regulation of plasma gelsolin by DNA methylation in ovarian cancer chemo-resistance.
    3. Gelsolin, an Actin-Binding Protein: Bioinformatic Analysis and Functional Significance in Urothelial Bladder Carcinoma.
      Title: Gelsolin, an Actin-Binding Protein: Bioinformatic Analysis and Functional Significance in Urothelial Bladder Carcinoma.
    4. mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.
      Title: mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.
    5. GSN gene frameshift mutations in Alzheimer's disease.
      Title: GSN gene frameshift mutations in Alzheimer's disease.
    6. Role and therapeutic potential of gelsolin in atherosclerosis.
      Title: Role and therapeutic potential of gelsolin in atherosclerosis.
    7. Fusion of the High-mobility Group AT-Hook 2 (HMGA2) and the Gelsolin (GSN) Genes in Lipomas With t(9;12)(q33;q14) Chromosomal Translocation.
      Title: Fusion of the High-mobility Group AT-Hook 2 (HMGA2) and the Gelsolin (GSN) Genes in Lipomas With t(9;12)(q33;q14) Chromosomal Translocation.
    8. HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein.
      Title: HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein.
    9. Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance.
      Title: Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance.
    10. Emerging roles of plasma gelsolin in tumorigenesis and modulating the tumor microenvironment.
      Title: Emerging roles of plasma gelsolin in tumorigenesis and modulating the tumor microenvironment.
    Submit: New GeneRIF Correction See all GeneRIFs (177)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Finnish type amyloidosis
    MedGen: C1622345 OMIM: 105120 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of gelsolin by siRNA inhibits early HIV-1 infection and HIV-1 Env (gp120/gp41)-mediated membrane fusion in permissive lymphocytes PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Gelsolin overexpression impairs HIV-1 gp120-induced cortical F-actin reorganization and capping and gp120-mediated CD4-CCR5 and CD4-CXCR4 redistribution in permissive lymphocytes PubMed
    Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of gelsolin (GSN) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    vpr The G5 domain of gelsolin inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp313L0718

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables myosin II binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatidylinositol 3-kinase catalytic subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament capping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament capping ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament severing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament severing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amyloid fibril formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiac muscle cell contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hepatocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of viral entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of actin nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of keratinocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein processing in phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment of T cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of plasma membrane raft polarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in relaxation of cardiac muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in renal protein absorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to muscle stretch ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in sequestering of actin monomers IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in striated muscle atrophy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cap IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in blood microparticle HDA PubMed 
    colocalizes_with cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    gelsolin
    Names
    actin-depolymerizing factor
    brevin
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012872.2 RefSeqGene

      Range
      72081..136761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000177.5 → NP_000168.1  gelsolin isoform a precursor

      See identical proteins and their annotated locations for NP_000168.1

      Status: REVIEWED

      Source sequence(s)
      BC026033, DB250757
      Consensus CDS
      CCDS6828.1
      UniProtKB/Swiss-Prot
      A2A418, A8MUD1, A8MYN7, B7Z373, B7Z5V1, F5H1A8, P06396, Q5T0I2, Q8WVV7
      UniProtKB/TrEMBL
      A0A384MEF1, B7Z9A0
      Related
      ENSP00000362924.4, ENST00000373818.8
      Conserved Domains (6) summary
      cd11288
      Location:561 → 649
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:186 → 275
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:59 → 171
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:666 → 764
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:295 → 395
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:439 → 539
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    2. NM_001127662.2 → NP_001121134.1  gelsolin isoform b

      See identical proteins and their annotated locations for NP_001121134.1

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491, DA450851
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    3. NM_001127663.2 → NP_001121135.2  gelsolin isoform f

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491, DA294394, DA394782
      Consensus CDS
      CCDS75890.1
      UniProtKB/TrEMBL
      A0A0A0MT01, B7Z6N2
      Related
      ENSP00000409358.2, ENST00000449733.7
      Conserved Domains (6) summary
      cd11288
      Location:546 → 634
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:171 → 260
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:44 → 156
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:651 → 749
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:280 → 380
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:424 → 524
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    4. NM_001127664.2 → NP_001121136.1  gelsolin isoform b

      See identical proteins and their annotated locations for NP_001121136.1

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491, DA294394, DB170452
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    5. NM_001127665.2 → NP_001121137.1  gelsolin isoform b

      See identical proteins and their annotated locations for NP_001121137.1

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491, DC370937
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    6. NM_001127666.2 → NP_001121138.1  gelsolin isoform c

      See identical proteins and their annotated locations for NP_001121138.1

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491, DC341948
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Related
      ENSP00000362914.3, ENST00000373808.8
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    7. NM_001127667.2 → NP_001121139.1  gelsolin isoform c

      See identical proteins and their annotated locations for NP_001121139.1

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491, DC316173
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    8. NM_001258029.2 → NP_001244958.1  gelsolin isoform d

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS75891.1
      UniProtKB/TrEMBL
      A0A0A0MS51, B7Z992
      Related
      ENSP00000377882.3, ENST00000394353.7
      Conserved Domains (6) summary
      cd11288
      Location:527 → 615
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:152 → 241
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:25 → 137
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:632 → 730
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:261 → 361
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:405 → 505
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    9. NM_001258030.2 → NP_001244959.1  gelsolin isoform e

      Status: REVIEWED

      Source sequence(s)
      AK295572, AK299453, AL513122, BC017491, DC378873
      Consensus CDS
      CCDS65118.1
      UniProtKB/TrEMBL
      B7Z992
      Related
      ENSP00000445823.1, ENST00000545652.6
      Conserved Domains (6) summary
      cd11288
      Location:518 → 606
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:143 → 232
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:16 → 128
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:623 → 721
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:252 → 352
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:396 → 496
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    10. NM_001353053.1 → NP_001339982.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL137068, AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    11. NM_001353054.1 → NP_001339983.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL137068, AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Related
      ENSP00000362929.2, ENST00000373823.7
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    12. NM_001353055.2 → NP_001339984.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    13. NM_001353056.2 → NP_001339985.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    14. NM_001353057.2 → NP_001339986.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    15. NM_001353058.2 → NP_001339987.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    16. NM_001353059.2 → NP_001339988.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    17. NM_001353060.2 → NP_001339989.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    18. NM_001353061.2 → NP_001339990.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    19. NM_001353062.1 → NP_001339991.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    20. NM_001353063.2 → NP_001339992.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    21. NM_001353064.2 → NP_001339993.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    22. NM_001353065.2 → NP_001339994.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    23. NM_001353066.2 → NP_001339995.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    24. NM_001353067.2 → NP_001339996.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    25. NM_001353068.2 → NP_001339997.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    26. NM_001353069.2 → NP_001339998.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    27. NM_001353070.2 → NP_001339999.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    28. NM_001353071.2 → NP_001340000.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    29. NM_001353072.2 → NP_001340001.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    30. NM_001353073.2 → NP_001340002.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    31. NM_001353074.2 → NP_001340003.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    32. NM_001353075.1 → NP_001340004.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    33. NM_001353076.2 → NP_001340005.1  gelsolin isoform g

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS94475.1
      UniProtKB/TrEMBL
      A0A8V8TND7, B7Z9A0
      Related
      ENSP00000514432.1, ENST00000699558.1
      Conserved Domains (6) summary
      cd11288
      Location:534 → 622
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:159 → 248
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:32 → 144
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:639 → 737
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:268 → 368
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:412 → 512
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    34. NM_001353077.1 → NP_001340006.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    35. NM_001353078.2 → NP_001340007.1  gelsolin isoform h

      Status: REVIEWED

      Source sequence(s)
      AL513122
      UniProtKB/TrEMBL
      B3KS49
      Conserved Domains (4) summary
      cd11288
      Location:292 → 380
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:397 → 495
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:26 → 126
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:170 → 270
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    36. NM_198252.3 → NP_937895.1  gelsolin isoform b

      See identical proteins and their annotated locations for NP_937895.1

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Related
      ENSP00000404226.2, ENST00000432226.7
      Conserved Domains (6) summary
      cd11288
      Location:510 → 598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135 → 224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388 → 488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      121201483..121332842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423273.1 → XP_047279229.1  gelsolin isoform X5

    2. XM_047423267.1 → XP_047279223.1  gelsolin isoform X4

    3. XM_047423268.1 → XP_047279224.1  gelsolin isoform X4

    4. XM_047423272.1 → XP_047279228.1  gelsolin isoform X5

    5. XM_047423265.1 → XP_047279221.1  gelsolin isoform X1

    6. XM_017014645.2 → XP_016870134.1  gelsolin isoform X3

      UniProtKB/TrEMBL
      B7Z9A0
      Conserved Domains (6) summary
      cd11288
      Location:531 → 619
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:156 → 245
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:29 → 141
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:636 → 734
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:265 → 365
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:409 → 509
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    7. XM_047423271.1 → XP_047279227.1  gelsolin isoform X4

    8. XM_011518585.2 → XP_011516887.1  gelsolin isoform X2

      UniProtKB/TrEMBL
      B7Z9A0
      Conserved Domains (6) summary
      cd11288
      Location:540 → 628
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:165 → 254
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:38 → 150
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:645 → 743
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:274 → 374
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:418 → 518
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    9. XM_047423270.1 → XP_047279226.1  gelsolin isoform X4

    10. XM_047423266.1 → XP_047279222.1  gelsolin isoform X3

    11. XM_047423269.1 → XP_047279225.1  gelsolin isoform X4

    12. XM_005251944.2 → XP_005252001.1  gelsolin isoform X4

      See identical proteins and their annotated locations for XP_005252001.1

      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146 → 235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19 → 131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626 → 724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255 → 355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399 → 499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    13. XM_011518594.2 → XP_011516896.1  gelsolin isoform X6

      Conserved Domains (5) summary
      cd11288
      Location:352 → 440
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:457 → 555
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:86 → 186
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:230 → 330
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:12 → 66
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      133397510..133528852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362811.1 → XP_054218786.1  gelsolin isoform X1

    2. XM_054362812.1 → XP_054218787.1  gelsolin isoform X1

    3. XM_054362815.1 → XP_054218790.1  gelsolin isoform X3

    4. XM_054362818.1 → XP_054218793.1  gelsolin isoform X4

    5. XM_054362813.1 → XP_054218788.1  gelsolin isoform X2

    6. XM_054362817.1 → XP_054218792.1  gelsolin isoform X4

    7. XM_054362814.1 → XP_054218789.1  gelsolin isoform X3

    8. XM_054362816.1 → XP_054218791.1  gelsolin isoform X4

    9. XM_054362819.1 → XP_054218794.1  gelsolin isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06396.1 GenPept UniProtKB/Swiss-Prot:P06396

    Gene LinkOut

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