ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZC3HAV1provided by HGNC
Official Full Name: zinc finger CCCH-type containing, antiviral 1provided by HGNC
Primary source: HGNC:HGNC:23721
See related: Ensembl:ENSG00000105939 MIM:607312; AllianceGenome:HGNC:23721
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2
Summary: This gene encodes a CCCH-type zinc finger protein. This antiviral protein inhibits viral replication by recruiting cellular RNA degradation machineries to degrade viral mRNAs. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses, including Ebola virus, HIV and SARS-CoV-2 (which causes COVID-19). [provided by RefSeq, Sep 2021]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Ubiquitous expression in bone marrow (RPKM 17.0), lymph node (RPKM 9.0) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q34

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (139043515..139109720, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (140356423..140423001, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (138728261..138794466, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endogenous ZAP affects Zika virus RNA interactome.
Title: Endogenous ZAP affects Zika virus RNA interactome.
Association of ZC3HAV1 single nucleotide polymorphisms with the susceptibility of Vogt-Koyanagi-Harada Disease.
Title: Association of ZC3HAV1 single nucleotide polymorphisms with the susceptibility of Vogt-Koyanagi-Harada Disease.
Expression of Zinc-Finger Antiviral Protein in hCMEC/D3 Human Cerebral Microvascular Endothelial Cells: Effect of a Toll-Like Receptor 3 Agonist.
Title: Expression of Zinc-Finger Antiviral Protein in hCMEC/D3 Human Cerebral Microvascular Endothelial Cells: Effect of a Toll-Like Receptor 3 Agonist.
ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition.
Title: ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition.
The low abundance of CpG in the SARS-CoV-2 genome is not an evolutionarily signature of ZAP.
Title: The low abundance of CpG in the SARS-CoV-2 genome is not an evolutionarily signature of ZAP.
Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
Title: Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
ZC3HAV1 promotes the proliferation and metastasis via regulating KRAS in pancreatic cancer.
Title: ZC3HAV1 promotes the proliferation and metastasis via regulating KRAS in pancreatic cancer.
The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts.
Title: The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts.
Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7.
Title: Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7.
The Interaction of Human and Epstein-Barr Virus miRNAs with Multiple Sclerosis Risk Loci.
Title: The Interaction of Human and Epstein-Barr Virus miRNAs with Multiple Sclerosis Risk Loci.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ZC3HAV1	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Cellular biotinylated zinc finger CCCH-type, antiviral 1 (ZC3HAV1) protein is incorporated into HIV-1 Gag virus-like particles	PubMed
	gag	Interaction of HIV-1 Gag with zinc finger CCCH-type, antiviral 1 (ZC3HAV1) is identified in a series of six affinity purification/mass spectrometry screens	PubMed
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human zinc finger CCCH-type, antiviral 1 (ZC3HAV1) at amino acid residues 260-261 by the HIV-1 protease	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S2505 (e-PCR), detects polymorphism
- UniSTS:76301

D7S2900 (e-PCR)
- UniSTS:6417

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-83458 (e-PCR)
- UniSTS:101948

GDB:1317546 (e-PCR)
- UniSTS:42828

ZAP_1348 (e-PCR)
- UniSTS:277873

ZAP_v431 (e-PCR)
- UniSTS:277873

RH45679 (e-PCR)
- UniSTS:4211

D1S1423 (e-PCR)
- UniSTS:149619

SHGC-67307 (e-PCR)
- UniSTS:89991

D7S2505 (e-PCR), detects polymorphism
- UniSTS:30095

SGC44417 (e-PCR)
- UniSTS:55441

D7S3188 (e-PCR)
- UniSTS:225970

D7S3189 (e-PCR)
- UniSTS:225971

RH18282 (e-PCR)
- UniSTS:17852

GDB:1317718 (e-PCR)
- UniSTS:74220

Clone Names

FLJ13288, MGC48898, DKFZp686F2052, DKFZp686H1869, DKFZp686O19171

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables NAD+ binding	IMP Inferred from Mutant Phenotype more info	PubMed
NOT enables NAD+-protein ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables NAD+-protein poly-ADP-ribosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA binding	HDA more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of RIG-I signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interferon-alpha production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interferon-beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type I interferon production	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in protein poly-ADP-ribosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger CCCH-type antiviral protein 1

Names: ADP-ribosyltransferase diphtheria toxin-like 13; inactive Poly [ADP-ribose] polymerase 13; zinc finger CCCH domain-containing protein 2; zinc finger CCCH-type, antiviral 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029457.1 RefSeqGene

Range

5000..71205

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001363491.2 → NP_001350420.1 zinc finger CCCH-type antiviral protein 1 isoform 3

Status: REVIEWED

Source sequence(s)

AC018644, AC083868, AI133088, BC040956, BU634030, BX571742, BX647974

Consensus CDS

CCDS94214.1

UniProtKB/TrEMBL

A8K9U6, C9J6P4

Related

ENSP00000418385.1, ENST00000464606.5

Conserved Domains (2) summary

smart00678
Location:729 → 811

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd01439
Location:906 → 1015

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
NM_020119.4 → NP_064504.2 zinc finger CCCH-type antiviral protein 1 isoform 1

See identical proteins and their annotated locations for NP_064504.2

Status: REVIEWED

Description

Transcript Variant: This variant encodes isoform 1.

Source sequence(s)

AC018644, AC083868, BC040956, BX571742, BX647974

Consensus CDS

CCDS5851.1

UniProtKB/Swiss-Prot

A4D1R2, A4D1S4, Q7Z2W4, Q8IW57, Q8TAJ3, Q96N79, Q9H8R9, Q9P0Y7

UniProtKB/TrEMBL

A8K9U6

Related

ENSP00000242351.5, ENST00000242351.10

Conserved Domains (3) summary

smart00678
Location:607 → 689

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd01439
Location:784 → 893

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

pfam00644
Location:727 → 893

PARP; Poly(ADP-ribose) polymerase catalytic domain
NM_024625.4 → NP_078901.3 zinc finger CCCH-type antiviral protein 1 isoform 2

See identical proteins and their annotated locations for NP_078901.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and lacks several downstream exons, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC018644

Consensus CDS

CCDS55171.1

UniProtKB/TrEMBL

A0A514C937

Related

ENSP00000419855.1, ENST00000471652.1

Conserved Domains (1) summary

smart00678
Location:607 → 689

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis