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    STK38 serine/threonine kinase 38 [ Homo sapiens (human) ]

    Gene ID: 11329, updated on 28-Oct-2024

    Summary

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    Official Symbol
    STK38provided by HGNC
    Official Full Name
    serine/threonine kinase 38provided by HGNC
    Primary source
    HGNC:HGNC:17847
    See related
    Ensembl:ENSG00000112079 MIM:606964; AllianceGenome:HGNC:17847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NDR; NDR1
    Summary
    This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 16.7), colon (RPKM 16.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STK38 in Genome Data Viewer
    Location:
    6p21.31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36493892..36547479, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36314555..36368143, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36461669..36515256, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17114 Neighboring gene ETV7 and PTX1 antisense RNA 1 Neighboring gene peroxisomal testis enriched protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24427 Neighboring gene PXT1 intron CAGE-defined low expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24429 Neighboring gene RNA, 7SL, cytoplasmic 502, pseudogene Neighboring gene potassium channel tetramerization domain containing 20 Neighboring gene uncharacterized LOC124901558 Neighboring gene RNA, 7SL, cytoplasmic 748, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36514791-36515314 Neighboring gene MPRA-validated peak5783 silencer Neighboring gene MPRA-validated peak5784 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36544382-36545325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24430 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36561915-36562596 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36564442-36564942 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36564943-36565443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36567225-36567726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36567727-36568226 Neighboring gene MPRA-validated peak5786 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24432 Neighboring gene serine and arginine rich splicing factor 3 Neighboring gene microRNA 3925

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. STK38 is a PPARγ-interacting protein promoting adipogenesis. Qian K, et al. Adipocyte, 2021 Dec. PMID 34670478, Free PMC Article
    2. Asiatic acid promotes p21(WAF1/CIP1) protein stability through attenuation of NDR1/2 dependent phosphorylation of p21(WAF1/ CIP1) in HepG2 human hepatoma cells. Chen JY, et al. Asian Pac J Cancer Prev, 2014. PMID 24568526
    3. Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling. Hergovich A. Cell Biosci, 2013 Aug 28. PMID 23985307, Free PMC Article
    4. The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition. Enomoto A, et al. Eur J Cancer, 2013 Nov. PMID 23886587
    5. STK38 promotes ATM activation by acting as a reader of histone H4 ufmylation. Qin B, et al. Sci Adv, 2020 Jun. PMID 32537488, Free PMC Article

    See all (155) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.
      Title: Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.
    2. Prognostic and Immunological Role of STK38 across Cancers: Friend or Foe?
      Title: Prognostic and Immunological Role of STK38 across Cancers: Friend or Foe?
    3. NDR1 increases NOTCH1 signaling activity by impairing Fbw7 mediated NICD degradation to enhance breast cancer stem cell properties.
      Title: NDR1 increases NOTCH1 signaling activity by impairing Fbw7 mediated NICD degradation to enhance breast cancer stem cell properties.
    4. STK38 is a PPARgamma-interacting protein promoting adipogenesis.
      Title: STK38 is a PPARγ-interacting protein promoting adipogenesis.
    5. The STK38-XPO1 axis, a new actor in physiology and cancer.
      Title: The STK38-XPO1 axis, a new actor in physiology and cancer.
    6. our results reveal STK38 as an activator of XPO1, behaving as a gatekeeper of nuclear export. These observations establish a novel mechanism of XPO1-dependent cargo export regulation by phosphorylation of XPO1's C-terminal auto-inhibitory domain.
      Title: STK38 kinase acts as XPO1 gatekeeper regulating the nuclear export of autophagy proteins and other cargoes.
    7. The activation segment of NDR1 influences interaction with MST1/MST2 and Furry.
      Title: Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
    8. Relied on its interaction with serine/threonine-protein kinase 38 (Stk38) to inhibit ubiquitination.
      Title: Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling.
    9. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop.
      Title: Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop.
    10. Study provides evidence for an inhibitory role of SOCS2 in TNFalpha induced NF-kappa B activation, identifies NDR1 as a novel substrate of SOCS2, and demonstrates that SOCS2 and TNFalpha induced NF-kappa B signaling are linked through NDR1.
      Title: The ubiquitin ligase Cullin5(SOCS2) regulates NDR1/STK38 stability and NF-κB transactivation.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Two related serine-threonine kinases, nuclear Dbf2 related 1 (NDR1) and NDR2, are incorporated into HIV-1 particles and are cleaved by the HIV-1 protease (PR), both within virions and within producer cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ38018

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UFM1-modified protein reader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cadherin binding HDA PubMed 
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone reader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mitogen-activated protein kinase kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-like protein reader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein modification process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 38
    Names
    NDR1 protein kinase
    Ndr Ser/Thr kinase-like protein
    nuclear Dbf2-related kinase 1
    NP_001292031.1
    NP_009202.1
    XP_016865715.1
    XP_047274095.1
    XP_047274096.1
    XP_047274097.1
    XP_047274098.1
    XP_047274099.1
    XP_047274100.1
    XP_054210120.1
    XP_054210121.1
    XP_054210122.1
    XP_054210123.1
    XP_054210124.1
    XP_054210125.1
    XP_054210126.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305102.2 → NP_001292031.1  serine/threonine-protein kinase 38

      See identical proteins and their annotated locations for NP_001292031.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC012085, BC095413, CB852856, DA459946
      Consensus CDS
      CCDS4822.1
      UniProtKB/Swiss-Prot
      Q15208, Q503A1
      UniProtKB/TrEMBL
      B2R6F9
      Conserved Domains (1) summary
      cd05628
      Location:87 → 462
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

    2. NM_007271.4 → NP_009202.1  serine/threonine-protein kinase 38

      See identical proteins and their annotated locations for NP_009202.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC012085, CB852856, DA459946
      Consensus CDS
      CCDS4822.1
      UniProtKB/Swiss-Prot
      Q15208, Q503A1
      UniProtKB/TrEMBL
      B2R6F9
      Related
      ENSP00000229812.7, ENST00000229812.8
      Conserved Domains (1) summary
      cd05628
      Location:87 → 462
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      36493892..36547479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010226.2 → XP_016865715.1  serine/threonine-protein kinase 38 isoform X2

      UniProtKB/TrEMBL
      B2R6F9
      Conserved Domains (2) summary
      smart00220
      Location:89 → 382
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:87 → 424
      PKc_like; Protein Kinases, catalytic domain

    2. XM_047418142.1 → XP_047274098.1  serine/threonine-protein kinase 38 isoform X2

    3. XM_047418140.1 → XP_047274096.1  serine/threonine-protein kinase 38 isoform X1

      UniProtKB/Swiss-Prot
      Q15208, Q503A1

    4. XM_047418143.1 → XP_047274099.1  serine/threonine-protein kinase 38 isoform X2

    5. XM_047418141.1 → XP_047274097.1  serine/threonine-protein kinase 38 isoform X1

      UniProtKB/Swiss-Prot
      Q15208, Q503A1

    6. XM_047418139.1 → XP_047274095.1  serine/threonine-protein kinase 38 isoform X1

      UniProtKB/Swiss-Prot
      Q15208, Q503A1

    7. XM_047418144.1 → XP_047274100.1  serine/threonine-protein kinase 38 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      36314555..36368143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354149.1 → XP_054210124.1  serine/threonine-protein kinase 38 isoform X2

    2. XM_054354148.1 → XP_054210123.1  serine/threonine-protein kinase 38 isoform X2

    3. XM_054354146.1 → XP_054210121.1  serine/threonine-protein kinase 38 isoform X1

      UniProtKB/Swiss-Prot
      Q15208, Q503A1

    4. XM_054354150.1 → XP_054210125.1  serine/threonine-protein kinase 38 isoform X2

    5. XM_054354147.1 → XP_054210122.1  serine/threonine-protein kinase 38 isoform X1

      UniProtKB/Swiss-Prot
      Q15208, Q503A1

    6. XM_054354145.1 → XP_054210120.1  serine/threonine-protein kinase 38 isoform X1

      UniProtKB/Swiss-Prot
      Q15208, Q503A1

    7. XM_054354151.1 → XP_054210126.1  serine/threonine-protein kinase 38 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15208.1 GenPept UniProtKB/Swiss-Prot:Q15208

    Gene LinkOut

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