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    SOX5 SRY-box transcription factor 5 [ Homo sapiens (human) ]

    Gene ID: 6660, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SOX5provided by HGNC
    Official Full Name
    SRY-box transcription factor 5provided by HGNC
    Primary source
    HGNC:HGNC:11201
    See related
    Ensembl:ENSG00000134532 MIM:604975; AllianceGenome:HGNC:11201
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L-SOX5; LAMSHF; L-SOX5B; L-SOX5F
    Summary
    This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 2.2), brain (RPKM 1.6) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SOX5 in Genome Data Viewer
    Location:
    12p12.1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (23529504..24562650, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (23401301..24433529, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (23682438..24715425, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6100 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:22778539-22779228 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:22852449-22852990 Neighboring gene long intergenic non-protein coding RNA 2955 Neighboring gene MPRA-validated peak1602 silencer Neighboring gene ethanolamine kinase 1 Neighboring gene ribosomal protein S27 pseudogene 22 Neighboring gene MPRA-validated peak1603 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:23178329-23179078 Neighboring gene VISTA enhancer hs1603 Neighboring gene MPRA-validated peak1605 silencer Neighboring gene Sharpr-MPRA regulatory region 9485 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:23627288-23627862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:23627863-23628437 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:23662216-23662400 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26611 Neighboring gene NANOG hESC enhancer GRCh37_chr12:23695058-23695588 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:23738604-23739190 Neighboring gene uncharacterized LOC105369697 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:23793632-23794207 Neighboring gene Sharpr-MPRA regulatory region 8728 Neighboring gene NANOG hESC enhancer GRCh37_chr12:23909365-23909887 Neighboring gene MPRA-validated peak1610 silencer Neighboring gene MPRA-validated peak1611 silencer Neighboring gene MPRA-validated peak1613 silencer Neighboring gene Sharpr-MPRA regulatory region 3652 Neighboring gene Sharpr-MPRA regulatory region 12792 Neighboring gene VISTA enhancer hs895 Neighboring gene MPRA-validated peak1614 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:24369389-24370015 Neighboring gene Sharpr-MPRA regulatory region 6359 Neighboring gene SOX5 antisense RNA 1 Neighboring gene microRNA 920 Neighboring gene NANOG hESC enhancer GRCh37_chr12:24744672-24745173 Neighboring gene uncharacterized LOC105369698 Neighboring gene long intergenic non-protein coding RNA 477 Neighboring gene lysine rich nucleolar protein 1 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 102

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Preferential expression and frequent IgG responses of a tumor antigen, SOX5, in glioma patients. Ueda R, et al. Int J Cancer, 2007 Apr 15. PMID 17230535
    2. DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer. Ma S, et al. Int J Cancer, 2009 May 15. PMID 19173284
    3. Widening of the genetic and clinical spectrum of Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency. Zawerton A, et al. Genet Med, 2020 Mar. PMID 31578471, Free PMC Article
    4. Identification of the SOX5 gene as a novel IGH-involved translocation partner in BCL2-negative follicular lymphoma with t(12;14)(p12.2;q32). Shiseki M, et al. Int J Hematol, 2015 Nov. PMID 26115875
    5. High levels of SOX5 decrease proliferative capacity of human B cells, but permit plasmablast differentiation. Rakhmanov M, et al. PLoS One, 2014. PMID 24945754, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lamb-Shaffer syndrome: 20 Spanish patients and literature review expands the view of neurodevelopmental disorders caused by SOX5 haploinsufficiency.
      Title: Lamb-Shaffer syndrome: 20 Spanish patients and literature review expands the view of neurodevelopmental disorders caused by SOX5 haploinsufficiency.
    2. EGR1/LINC00839/SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells.
      Title: EGR1/LINC00839/SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells.
    3. circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance and Inhibits the Development of Gastric Cancer with Cisplatin Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition.
      Title: circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance and Inhibits the Development of Gastric Cancer with Cisplatin Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition.
    4. SOX5 promotes cell growth and migration through modulating the DNMT1/p21 pathway in bladder cancer.
      Title: SOX5 promotes cell growth and migration through modulating the DNMT1/p21 pathway in bladder cancer.
    5. LINC00520 up-regulates SOX5 to promote cell proliferation and invasion by miR-4516 in human hepatocellular carcinoma.
      Title: LINC00520 up-regulates SOX5 to promote cell proliferation and invasion by miR-4516 in human hepatocellular carcinoma.
    6. miR-23a-3p regulated by LncRNA SNHG5 suppresses the chondrogenic differentiation of human adipose-derived stem cells via targeting SOX6/SOX5.
      Title: miR-23a-3p regulated by LncRNA SNHG5 suppresses the chondrogenic differentiation of human adipose-derived stem cells via targeting SOX6/SOX5.
    7. LncRNA UCC promotes epithelial-mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer.
      Title: LncRNA UCC promotes epithelial-mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer.
    8. Clinical spectrum and follow-up in six individuals with Lamb-Shaffer syndrome (SOX5).
      Title: Clinical spectrum and follow-up in six individuals with Lamb-Shaffer syndrome (SOX5).
    9. Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human melanocytes.
      Title: Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human melanocytes.
    10. High expression levels and localization of Sox5 in dilated cardiomyopathy.
      Title: High expression levels and localization of Sox5 in dilated cardiomyopathy.
    Submit: New GeneRIF Correction See all GeneRIFs (61)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Lamb-Shaffer syndrome
    MedGen: C4225202 OMIM: 616803 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2016-08-19)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2016-08-19)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
    EBI GWAS Catalog
    A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
    EBI GWAS Catalog
    Genome-wide association of lipid-lowering response to statins in combined study populations.
    EBI GWAS Catalog
    Genome-wide association study of PR interval.
    EBI GWAS Catalog
    Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).
    EBI GWAS Catalog
    Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
    EBI GWAS Catalog
    Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC35153

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asymmetric neuroblast division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cartilage condensation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cartilage development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to transforming growth factor beta stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chondrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cartilage development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of chondrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of chondrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of mesenchymal stem cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor SOX-5
    Names
    SRY (sex determining region Y)-box 5
    SRY-box 5

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029612.2 RefSeqGene

      Range
      617777..1037943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001261414.3 → NP_001248343.1  transcription factor SOX-5 isoform d

      See identical proteins and their annotated locations for NP_001248343.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AB081589, AC087244, BC060773, BM988193, BX098902, DA343699
      Consensus CDS
      CCDS58216.1
      UniProtKB/Swiss-Prot
      P35711
      Related
      ENSP00000493866.1, ENST00000646273.1
      Conserved Domains (1) summary
      cd01388
      Location:434 → 505
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

    2. NM_001261415.3 → NP_001248344.1  transcription factor SOX-5 isoform e

      See identical proteins and their annotated locations for NP_001248344.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate first exon compared to variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AB081589, AC087244, AK303970, BM988193, BX098902
      Consensus CDS
      CCDS58217.1
      UniProtKB/Swiss-Prot
      P35711
      Related
      ENSP00000443520.1, ENST00000545921.5
      Conserved Domains (1) summary
      cd01388
      Location:545 → 616
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    3. NM_001330785.2 → NP_001317714.1  transcription factor SOX-5 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (f) is shorter but has the same N- and C-termini compared to isoform a.
      Source sequence(s)
      AB081588, AC087244, BM988193, BX098902, DR003434
      Consensus CDS
      CCDS81672.1
      UniProtKB/TrEMBL
      F5H0I3
      Related
      ENSP00000439832.1, ENST00000537393.5
      Conserved Domains (1) summary
      cd01388
      Location:520 → 591
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    4. NM_006940.6 → NP_008871.3  transcription factor SOX-5 isoform a

      See identical proteins and their annotated locations for NP_008871.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a, also called L-SOX5A).
      Source sequence(s)
      AB081589, AC087244, BM988193, BX098902
      Consensus CDS
      CCDS8699.1
      UniProtKB/Swiss-Prot
      B7Z8V0, F5H5B0, P35711, Q86UK8, Q8J017, Q8J018, Q8J019, Q8J020, Q8N1D9, Q8N7E0, Q8TEA4
      Related
      ENSP00000398273.2, ENST00000451604.7
      Conserved Domains (1) summary
      cd01388
      Location:555 → 626
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    5. NM_152989.5 → NP_694534.1  transcription factor SOX-5 isoform b

      See identical proteins and their annotated locations for NP_694534.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b, also called L-SOX5B) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AB081588, AC087244, BC060773, BM988193, BX098902, DA343699
      UniProtKB/TrEMBL
      T2CYZ2
      Conserved Domains (1) summary
      cd01388
      Location:542 → 613
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    6. NM_178010.4 → NP_821078.1  transcription factor SOX-5 isoform c

      See identical proteins and their annotated locations for NP_821078.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate first exon in place of much of the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AB081589, AC087244, AK098610, BM988193, BX098902
      Consensus CDS
      CCDS41761.1
      UniProtKB/TrEMBL
      Q53EV3
      Related
      ENSP00000379328.2, ENST00000396007.6
      Conserved Domains (1) summary
      cd01388
      Location:169 → 240
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      23529504..24562650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449159.2 → XP_024304927.1  transcription factor SOX-5 isoform X10

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    2. XM_024449158.2 → XP_024304926.1  transcription factor SOX-5 isoform X10

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    3. XM_047429458.1 → XP_047285414.1  transcription factor SOX-5 isoform X10

    4. XM_017019891.2 → XP_016875380.1  transcription factor SOX-5 isoform X10

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    5. XM_047429461.1 → XP_047285417.1  transcription factor SOX-5 isoform X10

    6. XM_017019892.2 → XP_016875381.1  transcription factor SOX-5 isoform X10

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    7. XM_047429457.1 → XP_047285413.1  transcription factor SOX-5 isoform X10

    8. XM_024449157.2 → XP_024304925.1  transcription factor SOX-5 isoform X10

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    9. XM_017019893.2 → XP_016875382.1  transcription factor SOX-5 isoform X10

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    10. XM_024449154.2 → XP_024304922.1  transcription factor SOX-5 isoform X10

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    11. XM_011520835.3 → XP_011519137.1  transcription factor SOX-5 isoform X10

      See identical proteins and their annotated locations for XP_011519137.1

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    12. XM_017019890.2 → XP_016875379.1  transcription factor SOX-5 isoform X10

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    13. XM_047429459.1 → XP_047285415.1  transcription factor SOX-5 isoform X10

    14. XM_024449153.2 → XP_024304921.1  transcription factor SOX-5 isoform X10

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    15. XM_047429460.1 → XP_047285416.1  transcription factor SOX-5 isoform X10

    16. XM_024449150.2 → XP_024304918.1  transcription factor SOX-5 isoform X10

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    17. XM_047429456.1 → XP_047285412.1  transcription factor SOX-5 isoform X10

    18. XM_024449151.2 → XP_024304919.1  transcription factor SOX-5 isoform X10

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    19. XM_017019894.2 → XP_016875383.1  transcription factor SOX-5 isoform X10

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    20. XM_047429462.1 → XP_047285418.1  transcription factor SOX-5 isoform X10

    21. XM_047429465.1 → XP_047285421.1  transcription factor SOX-5 isoform X13

      Related
      ENSP00000515823.1, ENST00000704299.1

    22. XM_047429464.1 → XP_047285420.1  transcription factor SOX-5 isoform X12

    23. XM_011520833.3 → XP_011519135.1  transcription factor SOX-5 isoform X7

      See identical proteins and their annotated locations for XP_011519135.1

      Conserved Domains (1) summary
      cd01388
      Location:546 → 617
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    24. XM_047429455.1 → XP_047285411.1  transcription factor SOX-5 isoform X9

    25. XM_047429454.1 → XP_047285410.1  transcription factor SOX-5 isoform X8

    26. XM_047429453.1 → XP_047285409.1  transcription factor SOX-5 isoform X6

    27. XM_047429452.1 → XP_047285408.1  transcription factor SOX-5 isoform X5

    28. XM_017019889.2 → XP_016875378.1  transcription factor SOX-5 isoform X4

    29. XM_017019888.2 → XP_016875377.1  transcription factor SOX-5 isoform X3

    30. XM_047429451.1 → XP_047285407.1  transcription factor SOX-5 isoform X2

    31. XM_011520832.3 → XP_011519134.2  transcription factor SOX-5 isoform X1

    32. XM_047429463.1 → XP_047285419.1  transcription factor SOX-5 isoform X11

      UniProtKB/TrEMBL
      T2CYZ2

    33. XM_017019895.2 → XP_016875384.1  transcription factor SOX-5 isoform X10

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    34. XM_011520837.3 → XP_011519139.1  transcription factor SOX-5 isoform X10

      See identical proteins and their annotated locations for XP_011519139.1

      Conserved Domains (1) summary
      cd01388
      Location:543 → 614
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    35. XM_017019903.2 → XP_016875392.2  transcription factor SOX-5 isoform X15

      Related
      ENSP00000515822.1, ENST00000704298.1

    36. XM_017019902.2 → XP_016875391.2  transcription factor SOX-5 isoform X14

    37. XM_047429466.1 → XP_047285422.1  transcription factor SOX-5 isoform X16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      23401301..24433529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373061.1 → XP_054229036.1  transcription factor SOX-5 isoform X10

    2. XM_054373073.1 → XP_054229048.1  transcription factor SOX-5 isoform X10

    3. XM_054373070.1 → XP_054229045.1  transcription factor SOX-5 isoform X10

    4. XM_054373069.1 → XP_054229044.1  transcription factor SOX-5 isoform X10

    5. XM_054373064.1 → XP_054229039.1  transcription factor SOX-5 isoform X10

    6. XM_054373068.1 → XP_054229043.1  transcription factor SOX-5 isoform X10

    7. XM_054373075.1 → XP_054229050.1  transcription factor SOX-5 isoform X10

    8. XM_054373067.1 → XP_054229042.1  transcription factor SOX-5 isoform X10

    9. XM_054373071.1 → XP_054229046.1  transcription factor SOX-5 isoform X10

    10. XM_054373060.1 → XP_054229035.1  transcription factor SOX-5 isoform X10

    11. XM_054373072.1 → XP_054229047.1  transcription factor SOX-5 isoform X10

    12. XM_054373065.1 → XP_054229040.1  transcription factor SOX-5 isoform X10

    13. XM_054373074.1 → XP_054229049.1  transcription factor SOX-5 isoform X10

    14. XM_054373062.1 → XP_054229037.1  transcription factor SOX-5 isoform X10

    15. XM_054373066.1 → XP_054229041.1  transcription factor SOX-5 isoform X10

    16. XM_054373063.1 → XP_054229038.1  transcription factor SOX-5 isoform X10

    17. XM_054373076.1 → XP_054229051.1  transcription factor SOX-5 isoform X10

    18. XM_054373054.1 → XP_054229029.1  transcription factor SOX-5 isoform X4

    19. XM_054373053.1 → XP_054229028.1  transcription factor SOX-5 isoform X3

    20. XM_054373052.1 → XP_054229027.1  transcription factor SOX-5 isoform X2

    21. XM_054373081.1 → XP_054229056.1  transcription factor SOX-5 isoform X13

    22. XM_054373080.1 → XP_054229055.1  transcription factor SOX-5 isoform X12

    23. XM_054373057.1 → XP_054229032.1  transcription factor SOX-5 isoform X7

    24. XM_054373059.1 → XP_054229034.1  transcription factor SOX-5 isoform X9

    25. XM_054373058.1 → XP_054229033.1  transcription factor SOX-5 isoform X8

    26. XM_054373056.1 → XP_054229031.1  transcription factor SOX-5 isoform X6

    27. XM_054373055.1 → XP_054229030.1  transcription factor SOX-5 isoform X5

    28. XM_054373051.1 → XP_054229026.1  transcription factor SOX-5 isoform X1

    29. XM_054373079.1 → XP_054229054.1  transcription factor SOX-5 isoform X11

      UniProtKB/TrEMBL
      T2CYZ2

    30. XM_054373078.1 → XP_054229053.1  transcription factor SOX-5 isoform X10

    31. XM_054373077.1 → XP_054229052.1  transcription factor SOX-5 isoform X10

    32. XM_054373083.1 → XP_054229058.1  transcription factor SOX-5 isoform X15

    33. XM_054373082.1 → XP_054229057.1  transcription factor SOX-5 isoform X14

    34. XM_054373084.1 → XP_054229059.1  transcription factor SOX-5 isoform X16

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35711.3 GenPept UniProtKB/Swiss-Prot:P35711

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