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    LANCL1 LanC like glutathione S-transferase 1 [ Homo sapiens (human) ]

    Gene ID: 10314, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LANCL1provided by HGNC
    Official Full Name
    LanC like glutathione S-transferase 1provided by HGNC
    Primary source
    HGNC:HGNC:6508
    See related
    Ensembl:ENSG00000115365 MIM:604155; AllianceGenome:HGNC:6508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p40; GPR69A
    Summary
    This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
    Expression
    Ubiquitous expression in brain (RPKM 58.9), testis (RPKM 27.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LANCL1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (210431251..210477584, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (210912027..210958415, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (211295975..211341483, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124907972 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:211111447-211112014 Neighboring gene LANCL1 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:211225248-211226447 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:211229754-211230953 Neighboring gene myosin light chain 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:211294046-211295245 Neighboring gene NANOG hESC enhancer GRCh37_chr2:211307490-211308075 Neighboring gene NANOG hESC enhancer GRCh37_chr2:211346110-211346611 Neighboring gene NANOG hESC enhancer GRCh37_chr2:211405459-211406038 Neighboring gene CPS1 intron CAGE-defined high expression enhancer 1 Neighboring gene CPS1 intron CAGE-defined high expression enhancer 2 Neighboring gene carbamoyl-phosphate synthase 1 Neighboring gene CPS1 intronic transcript 1 Neighboring gene uncharacterized LOC107985978

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isolation, molecular characterization, and tissue-specific expression of a novel putative G protein-coupled receptor. Mayer H, et al. Biochim Biophys Acta, 1998 Feb 11. PMID 9512664
    2. Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes. Downey A, et al. Free Radic Biol Med, 2020 Dec. PMID 33049334
    3. LanCL1 protects prostate cancer cells from oxidative stress via suppression of JNK pathway. Wang J, et al. Cell Death Dis, 2018 Feb 7. PMID 29416001, Free PMC Article
    4. LanCL1 attenuates ischemia-induced oxidative stress by Sirt3-mediated preservation of mitochondrial function. Xie Z, et al. Brain Res Bull, 2018 Sep. PMID 30075199
    5. Organization and chromosomal localization of the human and mouse genes coding for LanC-like protein 1 (LANCL1). Mayer H, et al. Cytogenet Cell Genet, 2001. PMID 11474189

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress.
      Title: LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress.
    2. The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure.
      Title: The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure.
    3. LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1alpha/Sirt1 pathway.
      Title: LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway.
    4. Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes.
      Title: Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes.
    5. Results suggest that LanCL1 protects cells from oxidative stress, and promotes cell proliferation. LanCL1 reduces cell death via suppression of JNK signaling pathway.
      Title: LanCL1 protects prostate cancer cells from oxidative stress via suppression of JNK pathway.
    6. Oxygen and glucose deprivation (OGD) exposure induced a temporal increase and persistent decreases in the expression of LanCL1 at both mRNA and protein levels. Overexpression of LanCL1 by lentivirus transfection preserved cell viability, reduced lactate dehydrogenase release and attenuated apoptosis after OGD. LanCL1 stimulated mitochondrial enzyme activities and SOD2 deacetylation in a Sirt3-dependent manner.
      Title: LanCL1 attenuates ischemia-induced oxidative stress by Sirt3-mediated preservation of mitochondrial function.
    7. Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine beta-synthase: a target for neuronal antioxidant defense.
      Title: Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense.
    8. the crystal structures of human LanCL1, both free of and complexed with glutathione, revealing glutathione binding to a zinc ion at the putative active site formed by conserved GxxG motifs
      Title: Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables glutathione binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables low-density lipoprotein particle receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular detoxification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptide modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione S-transferase LANCL1
    Names
    40 kDa erythrocyte membrane protein
    G protein-coupled receptor 69A
    LanC (bacterial lantibiotic synthetase component C)-like 1
    LanC (bacterial lantibiotic synthetase component)
    LanC lantibiotic synthetase component C-like 1
    LanC like 1
    lanC-like protein 1
    NP_001130046.1
    NP_001130047.1
    NP_006046.1
    XP_005246300.1
    XP_054196149.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136574.2 → NP_001130046.1  glutathione S-transferase LANCL1

      See identical proteins and their annotated locations for NP_001130046.1

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC007970, BC028685, BX473106
      Consensus CDS
      CCDS2392.1
      UniProtKB/Swiss-Prot
      O43813
      UniProtKB/TrEMBL
      A0A024R453, B2R602, Q53TN2, Q6FHH6
      Related
      ENSP00000233714.4, ENST00000233714.8
      Conserved Domains (2) summary
      cd04794
      Location:62 → 395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:1 → 89
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    2. NM_001136575.2 → NP_001130047.1  glutathione S-transferase LANCL1

      See identical proteins and their annotated locations for NP_001130047.1

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC007970, AK312381, BX473106, DC321883
      Consensus CDS
      CCDS2392.1
      UniProtKB/Swiss-Prot
      O43813
      UniProtKB/TrEMBL
      A0A024R453, B2R602, Q53TN2, Q6FHH6
      Related
      ENSP00000397646.2, ENST00000431941.6
      Conserved Domains (2) summary
      cd04794
      Location:62 → 395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:1 → 89
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    3. NM_006055.3 → NP_006046.1  glutathione S-transferase LANCL1

      See identical proteins and their annotated locations for NP_006046.1

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC007970, BX473106, DC324843, Y11395
      Consensus CDS
      CCDS2392.1
      UniProtKB/Swiss-Prot
      O43813
      UniProtKB/TrEMBL
      A0A024R453, B2R602, Q53TN2, Q6FHH6
      Related
      ENSP00000393597.2, ENST00000450366.7
      Conserved Domains (2) summary
      cd04794
      Location:62 → 395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:1 → 89
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      210431251..210477584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246243.3 → XP_005246300.1  glutathione S-transferase LANCL1 isoform X1

      See identical proteins and their annotated locations for XP_005246300.1

      UniProtKB/TrEMBL
      B2R602, Q6FHH6
      Conserved Domains (2) summary
      cd04794
      Location:74 → 407
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:13 → 101
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      210912027..210958415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340174.1 → XP_054196149.1  glutathione S-transferase LANCL1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43813.1 GenPept UniProtKB/Swiss-Prot:O43813

    Gene LinkOut

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