FSTL3 follistatin like 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FSTL3provided by HGNC
Official Full Name: follistatin like 3provided by HGNC
Primary source: HGNC:HGNC:3973
See related: Ensembl:ENSG00000070404 MIM:605343; AllianceGenome:HGNC:3973
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FLRG; FSRP
Summary: Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
Expression: Biased expression in placenta (RPKM 92.4), testis (RPKM 32.9) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (676392..683385)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (630475..637473)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (676392..683385)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stroma-associated FSTL3 is a factor of calcium channel-derived tumor fibrosis.
Title: Stroma-associated FSTL3 is a factor of calcium channel-derived tumor fibrosis.
Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon Cancer: Clinicopathologic Study.
Title: Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon Cancer: Clinicopathologic Study.
Follistatin and follistatin-like 3 in metabolic disorders.
Title: Follistatin and follistatin-like 3 in metabolic disorders.
FSTL3 partially mediates the association of increased nonalcoholic fatty liver disease fibrosis risk with acute myocardial infarction in patients with type 2 diabetes mellitus.
Title: FSTL3 partially mediates the association of increased nonalcoholic fatty liver disease fibrosis risk with acute myocardial infarction in patients with type 2 diabetes mellitus.
The cytoplasmic expression of FSTL3 correlates with colorectal cancer progression, metastasis status and prognosis.
Title: The cytoplasmic expression of FSTL3 correlates with colorectal cancer progression, metastasis status and prognosis.
FSTL3 is highly expressed in adipose tissue of individuals with overweight or obesity and is associated with inflammation.
Title: FSTL3 is highly expressed in adipose tissue of individuals with overweight or obesity and is associated with inflammation.
Regulation of follistatin-like 3 expression by miR-486-5p modulates gastric cancer cell proliferation, migration and tumor progression.
Title: Regulation of follistatin-like 3 expression by miR-486-5p modulates gastric cancer cell proliferation, migration and tumor progression.
Follistatin-Like 3 Correlates With Lymph Node Metastasis and Serves as a Biomarker of Extracellular Matrix Remodeling in Colorectal Cancer.
Title: Follistatin-Like 3 Correlates With Lymph Node Metastasis and Serves as a Biomarker of Extracellular Matrix Remodeling in Colorectal Cancer.
Alterations in activin A-myostatin-follistatin system associate with disease activity in inflammatory myopathies.
Title: Alterations in activin A-myostatin-follistatin system associate with disease activity in inflammatory myopathies.
[Expression Level of FLRG in Colon Cancer Tissue and Its Clinical Significance].
Title: [Expression Level of FLRG in Colon Cancer Tissue and Its Clinical Significance].

Submit: New GeneRIF Correction See all GeneRIFs (47)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH16457 (e-PCR)
- UniSTS:86076

REU1903 (e-PCR)
- UniSTS:257088

RH139332 (e-PCR)
- UniSTS:221418

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info
enables activin binding	IPI Inferred from Physical Interaction more info	PubMed
enables fibronectin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in hematopoietic progenitor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of activin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: follistatin-related protein 3

Names: follistatin-like 3 (secreted glycoprotein); follistatin-like protein 3; follistatin-related gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005860.3 → NP_005851.1 follistatin-related protein 3 precursor

See identical proteins and their annotated locations for NP_005851.1

Status: REVIEWED

Source sequence(s)

AY358917, BX439786

Consensus CDS

CCDS12040.1

UniProtKB/Swiss-Prot

A8K7E3, O95633

Related

ENSP00000166139.3, ENST00000166139.9

Conserved Domains (2) summary

smart00280
Location:120 → 167

KAZAL; Kazal type serine protease inhibitors

cl00097
Location:171 → 231

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...