Epha5 Eph receptor A5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Epha5provided by MGI
Official Full Name: Eph receptor A5provided by MGI
Primary source: MGI:MGI:99654
See related: Ensembl:ENSMUSG00000029245 AllianceGenome:MGI:99654
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: bsk; Cek7; Ehk1; Els1; Hek7; Rek7
Summary: Enables GPI-linked ephrin receptor activity. Involved in several processes, including ephrin receptor signaling pathway; nervous system development; and regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus and cellular response to forskolin. Located in adherens junction and cell periphery. Is expressed in several structures, including alimentary system; future midbrain; genitourinary system; nervous system; and sensory organ. Orthologous to human EPHA5 (EPH receptor A5). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in CNS E18 (RPKM 9.2), frontal lobe adult (RPKM 7.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 43.0 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (84199024..84565677, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (84054761..84417818, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long noncoding RNA ZFAS1 suppresses osteogenic differentiation of bone marrow-derived mesenchymal stem cells by upregulating miR-499-EPHA5 axis.
Title: Long noncoding RNA ZFAS1 suppresses osteogenic differentiation of bone marrow-derived mesenchymal stem cells by upregulating miR-499-EPHA5 axis.
Observations suggest that ephrin-A5 plays a key role in the development and/or function of neural pathways mediating mouse maternal care and anxiety.
Title: Decreased maternal behavior and anxiety in ephrin-A5(-/-) mice.
methylation of only six of 98 CpG dinucleotides within the EphA5 promoter blocks its transactivation by KLF16 but enables transactivation by KLF2 and KLF15.
Title: Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells.
We examined the roles of ephrin-A2 and ephrin-A5 signaling in contralateral targeting and topographic ordering in the ventral cochlear nucleus
Title: Ephrin-A2 and ephrin-A5 guide contralateral targeting but not topographic mapping of ventral cochlear nucleus axons.
Expression of ephrinA5-Fc decreases a population of cephalic neural crest precursors in the dorsal midline of the dien- and mesencephalon.
Title: In vivo expression of ephrinA5-Fc in mice results in cephalic neural crest agenesis and craniofacial abnormalities.
ephrinA5/EphA3 triggers proteolysis of the neural cell adhesion molecule (NCAM) by the metalloprotease a disintegrin and metalloprotease (ADAM)10 to promote growth cone collapse in neurons from mouse neocortex.
Title: EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease.
Results demonstrated that the ephrinA5-EphA4/EphA5 system plays an important role in the direct pathway-dependent regulation of the SNr in cocaine responses and would provide valuable therapeutic targets of cocaine addiction.
Title: Pathway-specific engagement of ephrinA5-EphA4/EphA5 system of the substantia nigra pars reticulata in cocaine-induced responses.
ephrin-A5 and EphA5 signals play a necessary, activity-independent role in the initiation of the early phases of synaptogenesis
Title: Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development.
We characterized EphA5 protein during development and conclude that EphA5 function is not limited to the developing mouse brain and may play a role in synaptic plasticity in the adult.
Title: Distribution of EphA5 receptor protein in the developing and adult mouse nervous system.
EphA5 receptor may be involved in mediation of aggressive behavior regulated, in part, by hypothalamic serotonin
Title: Changes in attack behavior and activity in EphA5 knockout mice.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:495883 (e-PCR)
- UniSTS:495883

Epha5 (e-PCR), detects polymorphism
- UniSTS:495883

AI854630 (e-PCR)
- UniSTS:165404

Els1 (e-PCR), detects polymorphism
- UniSTS:166212

NoName (e-PCR)
- UniSTS:548481

Epha5 (e-PCR), detects polymorphism
- UniSTS:527336

UniSTS:266988 (e-PCR)
- UniSTS:266988

Epha5 (e-PCR), detects polymorphism
- UniSTS:266988

AW125296 (e-PCR)
- UniSTS:179191

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ephrin receptor activity	ISO Inferred from Sequence Orthology more info
enables ephrin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cAMP-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to forskolin	IDA Inferred from Direct Assay more info	PubMed
involved_in dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IDA Inferred from Direct Assay more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of CREB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in rough endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ephrin type-A receptor 5

Names: EPH homology kinase 1; brain-specific kinase; eck-like sequence 1

NP_001389678.1

EC 2.7.10.1

NP_001389679.1

EC 2.7.10.1

NP_001389680.1

EC 2.7.10.1

NP_001389681.1

EC 2.7.10.1

NP_001389682.1

EC 2.7.10.1

NP_001389683.1

EC 2.7.10.1

NP_001389684.1

EC 2.7.10.1

NP_001389685.1

EC 2.7.10.1

NP_001389686.1

EC 2.7.10.1

NP_001389687.1

EC 2.7.10.1

NP_001389688.1

EC 2.7.10.1

NP_001389689.1

EC 2.7.10.1

NP_001389690.1

EC 2.7.10.1

NP_031963.2

EC 2.7.10.1

XP_006534832.1

EC 2.7.10.1

XP_030109983.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001402749.1 → NP_001389678.1 ephrin type-A receptor 5 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC101956, AC114638, AC129220, AC132597

Related

ENSMUSP00000109033.2, ENSMUST00000113406.8
NM_001402750.1 → NP_001389679.1 ephrin type-A receptor 5 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC101956, AC114638, AC129220, AC132597

UniProtKB/TrEMBL

E9PUQ2

Related

ENSMUSP00000109026.2, ENSMUST00000113399.6
NM_001402751.1 → NP_001389680.1 ephrin type-A receptor 5 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC101956, AC114638, AC129220, AC132597
NM_001402752.1 → NP_001389681.1 ephrin type-A receptor 5 isoform 4

Status: VALIDATED

Source sequence(s)

AC101956, AC114638, AC129220, AC132597
NM_001402753.1 → NP_001389682.1 ephrin type-A receptor 5 isoform 5

Status: VALIDATED

Source sequence(s)

AC101956, AC114638, AC129220, AC132597
NM_001402754.1 → NP_001389683.1 ephrin type-A receptor 5 isoform 6

Status: VALIDATED

Source sequence(s)

AC101956, AC114638, AC129220, AC132597
NM_001402755.1 → NP_001389684.1 ephrin type-A receptor 5 isoform 7

Status: VALIDATED

Source sequence(s)

AC101956, AC114638, AC129220, AC132597

UniProtKB/TrEMBL

E9PUQ4

Related

ENSMUSP00000109025.2, ENSMUST00000113398.8
NM_001402756.1 → NP_001389685.1 ephrin type-A receptor 5 isoform 9

Status: VALIDATED

Source sequence(s)

AC101956, AC114638, AC129220, AC132597
NM_001402757.1 → NP_001389686.1 ephrin type-A receptor 5 isoform 10

Status: VALIDATED

Source sequence(s)

AC101956, AC114638, AC129220, AC132597
NM_001402758.1 → NP_001389687.1 ephrin type-A receptor 5 isoform 11 precursor

Status: VALIDATED

Source sequence(s)

AC101956, AC114638, AC129220, AC132597
NM_001402759.1 → NP_001389688.1 ephrin type-A receptor 5 isoform 12

Status: VALIDATED

Source sequence(s)

AC101956, AC114638, AC129220, AC132597
NM_001402760.1 → NP_001389689.1 ephrin type-A receptor 5 isoform 13

Status: VALIDATED

Source sequence(s)

AC101956, AC114638, AC129220, AC132597

UniProtKB/TrEMBL

Q6PFV6

Related

ENSMUSP00000109028.2, ENSMUST00000113401.4
NM_001402761.1 → NP_001389690.1 ephrin type-A receptor 5 isoform 14 precursor

Status: VALIDATED

Source sequence(s)

AC101956, AC129220, AC132597
NM_007937.3 → NP_031963.2 ephrin type-A receptor 5 isoform 8 precursor

See identical proteins and their annotated locations for NP_031963.2

Status: VALIDATED

Source sequence(s)

AC101956, AC114638, AC129220, AC132597

Consensus CDS

CCDS19376.1

UniProtKB/Swiss-Prot

E9QPV2, Q60629

UniProtKB/TrEMBL

E9PUP9

Related

ENSMUSP00000060646.9, ENSMUST00000053733.15

Conserved Domains (7) summary

cd09546
Location:804 → 869

SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors

smart00454
Location:808 → 866

SAM; Sterile alpha motif

cd00063
Location:307 → 397

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:509 → 775

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam07714
Location:514 → 771

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:417 → 509

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:62 → 234

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

84199024..84565677 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534769.3 → XP_006534832.1 ephrin type-A receptor 5 isoform X1

UniProtKB/TrEMBL

E9PUP9, E9PUQ0

Related

ENSMUSP00000109030.2, ENSMUST00000113403.8

Conserved Domains (5) summary

cd09546
Location:968 → 1033

SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors

cd00063
Location:471 → 561

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:673 → 939

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:581 → 673

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:62 → 234

EphR_LBD; Ligand Binding Domain of Ephrin Receptors
XM_030254123.2 → XP_030109983.1 ephrin type-A receptor 5 isoform X3

UniProtKB/TrEMBL

E9PUP9

Conserved Domains (5) summary

cd09546
Location:897 → 962

SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors

cd00063
Location:400 → 490

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:602 → 868

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:510 → 602

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 163

EphR_LBD; Ligand Binding Domain of Ephrin Receptors