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    ST7 suppression of tumorigenicity 7 [ Homo sapiens (human) ]

    Gene ID: 7982, updated on 3-Nov-2024

    Summary

    Official Symbol
    ST7provided by HGNC
    Official Full Name
    suppression of tumorigenicity 7provided by HGNC
    Primary source
    HGNC:HGNC:11351
    See related
    Ensembl:ENSG00000004866 MIM:600833; AllianceGenome:HGNC:11351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HELG; RAY1; SEN4; TSG7; ETS7q; FAM4A; FAM4A1
    Summary
    The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 11.1), lung (RPKM 10.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ST7 in Genome Data Viewer
    Location:
    7q31.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (116953501..117230176)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (118268670..118545512)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116593555..116870230)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene uncharacterized LOC124901857 Neighboring gene greater CFTR locus negative regulatory element CR9 Neighboring gene Sharpr-MPRA regulatory region 2110 Neighboring gene uncharacterized LOC105375465 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18564 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:116593626-116594549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18567 Neighboring gene RNA, 5S ribosomal pseudogene 239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18568 Neighboring gene NANOG hESC enhancer GRCh37_chr7:116609424-116609981 Neighboring gene ST7 antisense RNA 1 Neighboring gene ST7 overlapping transcript 4 Neighboring gene tropomyosin 3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18569 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:116659304-116660503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26542 Neighboring gene microRNA 6132 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:116716803-116717302 Neighboring gene greater CFTR locus negative regulatory element NR4 Neighboring gene uncharacterized LOC124901732 Neighboring gene ST7 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26543 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:116794856-116795649 Neighboring gene greater CFTR locus negative regulatory element CR10 Neighboring gene greater CFTR locus negative regulatory element CR11 Neighboring gene ST7 overlapping transcript 3 Neighboring gene uncharacterized LOC105375466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26545 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 like 2 pseudogene Neighboring gene MT-ND2 pseudogene 37

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp762O2113

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    suppressor of tumorigenicity 7 protein
    Names
    family with sequence similarity 4, subfamily A, member 1
    suppression of tumorigenicity 7 (breast)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047088.1 RefSeqGene

      Range
      5175..281850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001369598.1NP_001356527.1  suppressor of tumorigenicity 7 protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS94182.1
      UniProtKB/TrEMBL
      A8K8K7, H7BXS2
      Related
      ENSP00000325673.3, ENST00000323984.8
      Conserved Domains (1) summary
      pfam04184
      Location:19576
      ST7; ST7 protein
    2. NM_001369599.1NP_001356528.1  suppressor of tumorigenicity 7 protein isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS94185.1
      UniProtKB/TrEMBL
      A8K8K7, B7Z4L1
      Related
      ENSP00000377093.4, ENST00000393447.8
      Conserved Domains (1) summary
      cd11557
      Location:11498
      ST7; Suppression of tumorigenicity 7
    3. NM_001369600.1NP_001356529.1  suppressor of tumorigenicity 7 protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS94186.1
      UniProtKB/TrEMBL
      A8K8K7, G3XAH9
      Related
      ENSP00000377090.3, ENST00000393444.7
      Conserved Domains (1) summary
      cd11557
      Location:11475
      ST7; Suppression of tumorigenicity 7
    4. NM_001369601.1NP_001356530.1  suppressor of tumorigenicity 7 protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS94181.1
      UniProtKB/TrEMBL
      A8K8K7, E7EPD9
      Related
      ENSP00000377095.1, ENST00000393449.5
      Conserved Domains (1) summary
      pfam04184
      Location:19571
      ST7; ST7 protein
    5. NM_001369602.1NP_001356531.1  suppressor of tumorigenicity 7 protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS94183.1
      UniProtKB/TrEMBL
      A8K8K7, B7Z4U3
      Related
      ENSP00000411118.1, ENST00000432298.5
      Conserved Domains (1) summary
      cd11557
      Location:8495
      ST7; Suppression of tumorigenicity 7
    6. NM_001369603.1NP_001356532.1  suppressor of tumorigenicity 7 protein isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS94184.1
      UniProtKB/TrEMBL
      A8K8K7, E7EPW5
      Related
      ENSP00000414031.1, ENST00000422922.5
      Conserved Domains (1) summary
      cd11557
      Location:8472
      ST7; Suppression of tumorigenicity 7
    7. NM_001369604.1NP_001356533.1  suppressor of tumorigenicity 7 protein isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC106873
      UniProtKB/TrEMBL
      B7Z573
      Conserved Domains (1) summary
      pfam04184
      Location:19525
      ST7; ST7 protein
    8. NM_001369606.1NP_001356535.1  suppressor of tumorigenicity 7 protein isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      UniProtKB/TrEMBL
      A8K8K7
      Related
      ENSP00000377089.1, ENST00000393443.5
      Conserved Domains (1) summary
      cd11557
      Location:4491
      ST7; Suppression of tumorigenicity 7
    9. NM_001369607.1NP_001356536.1  suppressor of tumorigenicity 7 protein isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      UniProtKB/TrEMBL
      A8K8K7
      Conserved Domains (1) summary
      cd11557
      Location:4468
      ST7; Suppression of tumorigenicity 7
    10. NM_018412.4NP_060882.2  suppressor of tumorigenicity 7 protein isoform 5

      See identical proteins and their annotated locations for NP_060882.2

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
      Consensus CDS
      CCDS5769.1
      UniProtKB/TrEMBL
      A8K8K7
      Related
      ENSP00000377097.3, ENST00000393451.7
      Conserved Domains (1) summary
      pfam04184
      Location:19553
      ST7; ST7 protein
    11. NM_021908.3NP_068708.1  suppressor of tumorigenicity 7 protein isoform 8

      See identical proteins and their annotated locations for NP_068708.1

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC106873
      Consensus CDS
      CCDS5770.1
      UniProtKB/Swiss-Prot
      A4D0V2, Q5CZ72, Q7LE31, Q7LE32, Q8NA32, Q8NEJ8, Q8TDI9, Q9BWX3, Q9BWX4, Q9NRC1, Q9NRC2, Q9NXZ7
      UniProtKB/TrEMBL
      B7Z573, X5DRA0
      Related
      ENSP00000265437.5, ENST00000265437.9
      Conserved Domains (1) summary
      pfam04184
      Location:19548
      ST7; ST7 protein

    RNA

    1. NR_161418.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873, HY033462
    2. NR_161419.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873, HY033462
    3. NR_161420.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873, HY033462
    4. NR_161421.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873, HY033462
    5. NR_161422.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873
    6. NR_161423.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002542, AC003987, AC106873

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      116953501..117230176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      118268670..118545512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)