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    Kif13a kinesin family member 13A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308173, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kif13aprovided by RGD
    Official Full Name
    kinesin family member 13Aprovided by RGD
    Primary source
    RGD:1307825
    See related
    EnsemblRapid:ENSRNOG00000001455 AllianceGenome:RGD:1307825
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including melanosome organization; plus-end-directed vesicle transport along microtubule; and protein transport. Predicted to be located in several cellular components, including centrosome; midbody; and trans-Golgi network membrane. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Orthologous to human KIF13A (kinesin family member 13A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 165.8), Muscle (RPKM 112.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kif13a in Genome Data Viewer
    Location:
    17p14
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (17972227..18154763)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (17766597..17948517)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (18151582..18335027)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor interacting Ras-like 1, pseudogene 1 Neighboring gene uncharacterized LOC108348531 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482696 Neighboring gene uncharacterized LOC134482695 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120097853 Neighboring gene ribosomal protein L27, pseudogene 4 Neighboring gene nucleoporin 153

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Polarized transport requires AP-1-mediated recruitment of KIF13A and KIF13B at the trans-Golgi. Montgomery AC, et al. Mol Biol Cell, 2024 May 1. PMID 38446634, Free PMC Article
    2. A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. Nakagawa T, et al. Cell, 2000 Nov 10. PMID 11106728
    3. AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis. Delevoye C, et al. J Cell Biol, 2009 Oct 19. PMID 19841138, Free PMC Article
    4. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Sagona AP, et al. Nat Cell Biol, 2010 Apr. PMID 20208530
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polarized transport requires AP-1-mediated recruitment of KIF13A and KIF13B at the trans-Golgi.
      Title: Polarized transport requires AP-1-mediated recruitment of KIF13A and KIF13B at the trans-Golgi.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in melanosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plus-end-directed vesicle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle cargo loading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF13A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107462.1 → NP_001100932.1  kinesin-like protein KIF13A

      See identical proteins and their annotated locations for NP_001100932.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473977
      UniProtKB/TrEMBL
      A6J709, D3ZM20
      Related
      ENSRNOP00000099796.1, ENSRNOT00000164569.1
      Conserved Domains (6) summary
      smart00129
      Location:9 → 296
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:383 → 480
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl22853
      Location:3 → 296
      Motor_domain; Myosin and Kinesin motor domain
      pfam12423
      Location:685 → 729
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1148 → 1207
      DUF3694; Kinesin protein
      pfam16183
      Location:293 → 405
      Kinesin_assoc; Kinesin-associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      17972227..18154763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276527.1 → XP_063132597.1  kinesin-like protein KIF13A isoform X1

    2. XM_063276529.1 → XP_063132599.1  kinesin-like protein KIF13A isoform X3

    3. XM_063276531.1 → XP_063132601.1  kinesin-like protein KIF13A isoform X5

    4. XM_063276533.1 → XP_063132603.1  kinesin-like protein KIF13A isoform X7

    5. XM_063276528.1 → XP_063132598.1  kinesin-like protein KIF13A isoform X2

    6. XM_063276530.1 → XP_063132600.1  kinesin-like protein KIF13A isoform X4

    7. XM_063276536.1 → XP_063132606.1  kinesin-like protein KIF13A isoform X10

    8. XM_063276532.1 → XP_063132602.1  kinesin-like protein KIF13A isoform X6

      Related
      ENSRNOP00000102070.1, ENSRNOT00000150235.1

    9. XM_063276535.1 → XP_063132605.1  kinesin-like protein KIF13A isoform X9

      Related
      ENSRNOP00000106511.1, ENSRNOT00000172992.1

    10. XM_063276538.1 → XP_063132608.1  kinesin-like protein KIF13A isoform X12

    11. XM_063276534.1 → XP_063132604.1  kinesin-like protein KIF13A isoform X8

    12. XM_063276539.1 → XP_063132609.1  kinesin-like protein KIF13A isoform X13

      Related
      ENSRNOP00000060386.3, ENSRNOT00000066447.3

    13. XM_063276537.1 → XP_063132607.1  kinesin-like protein KIF13A isoform X11

    14. XM_063276540.1 → XP_063132610.1  kinesin-like protein KIF13A isoform X14

      Related
      ENSRNOP00000104042.1, ENSRNOT00000158825.1
    Nucleotide Protein Strain
    Heading Accession and Version

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