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    Mpdu1 mannose-P-dolichol utilization defect 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303244, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Mpdu1provided by RGD
    Official Full Name
    mannose-P-dolichol utilization defect 1provided by RGD
    Primary source
    RGD:1307699
    See related
    EnsemblRapid:ENSRNOG00000012162 AllianceGenome:RGD:1307699
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in oligosaccharide biosynthetic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation If. Orthologous to human MPDU1 (mannose-P-dolichol utilization defect 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Kidney (RPKM 188.9), Adrenal (RPKM 121.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mpdu1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54873467..54880536, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54374719..54380301, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56261636..56267213, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene sex hormone binding globulin Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene FMR1 autosomal homolog 2 Neighboring gene SRY-box transcription factor 15 Neighboring gene Cd68 molecule Neighboring gene eukaryotic translation initiation factor 4A1 Neighboring gene small nucleolar RNA, H/ACA box 67

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MPDU1 mutations underlie a novel human congenital disorder of glycosylation, designated type If. Schenk B, et al. J Clin Invest, 2001 Dec. PMID 11733564, Free PMC Article
    2. Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals. Anand M, et al. Mol Biol Cell, 2001 Feb. PMID 11179430, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mannose-P-dolichol utilization defect 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107011.1 → NP_001100481.1  mannose-P-dolichol utilization defect 1 protein

      See identical proteins and their annotated locations for NP_001100481.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HFS6, D3Z865
      Related
      ENSRNOP00000096276.1, ENSRNOT00000103993.2
      Conserved Domains (1) summary
      TIGR00951
      Location:40 → 235
      2A43; Lysosomal Cystine Transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54873467..54880536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597283.3 → XP_017452772.1  mannose-P-dolichol utilization defect 1 protein isoform X2

    2. XM_063269031.1 → XP_063125101.1  mannose-P-dolichol utilization defect 1 protein isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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