Tamm41 TAM41 mitochondrial translocator assembly and maintenance homolog [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Tamm41provided by RGD
Full Name: TAM41 mitochondrial translocator assembly and maintenance homologprovided by RGD
Primary source: RGD:1586150
See related: EnsemblRapid:ENSRNOG00000007874 AllianceGenome:RGD:1586150
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TAM41
Summary: Enables phosphatidate cytidylyltransferase activity. Predicted to be involved in CDP-diacylglycerol biosynthetic process and cardiolipin biosynthetic process. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 56. Orthologous to human TAMM41 (TAM41 mitochondrial translocator assembly and maintenance homolog). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Thymus (RPKM 90.3), Spleen (RPKM 69.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (149743216..149776388, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (148070388..148103728, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (146922085..146954159, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDS activity present in mitochondria is mainly due to TAMM41, which is required for normal mitochondrial function.
Title: Mitochondrial CDP-diacylglycerol synthase activity is due to the peripheral protein, TAMM41 and not due to the integral membrane protein, CDP-diacylglycerol synthase 1.

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General gene information

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Markers

D4Rat141 (e-PCR)
- UniSTS:118817

RH139416 (e-PCR)
- UniSTS:221502

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidate cytidylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate cytidylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in cardiolipin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: phosphatidate cytidylyltransferase, mitochondrial

Names: CDP-DAG synthase; CDP-diacylglycerol synthase; MMP37-like protein, mitochondrial; TAM41, mitochondrial translocator assembly and maintenance protein, homolog; mitochondrial translocator assembly and maintenance protein 41 homolog

NP_001102112.1

EC 2.7.7.41

XP_038963787.1

EC 2.7.7.41

XP_038963788.1

EC 2.7.7.41

XP_038963789.2

EC 2.7.7.41

XP_063142375.1

EC 2.7.7.41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108642.1 → NP_001102112.1 phosphatidate cytidylyltransferase, mitochondrial

See identical proteins and their annotated locations for NP_001102112.1

Status: PROVISIONAL

Source sequence(s)

CH473964

UniProtKB/Swiss-Prot

D3ZKT0

Related

ENSRNOP00000102152.1, ENSRNOT00000166481.1

Conserved Domains (1) summary

pfam09139
Location:13 → 327

Mmp37; Mitochondrial matrix Mmp37

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

149743216..149776388 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107859.2 → XP_038963787.1 phosphatidate cytidylyltransferase, mitochondrial isoform X2

Conserved Domains (1) summary

pfam09139
Location:13 → 312

Mmp37; Mitochondrial matrix Mmp37
XM_063286305.1 → XP_063142375.1 phosphatidate cytidylyltransferase, mitochondrial isoform X1
XM_039107861.2 → XP_038963789.2 phosphatidate cytidylyltransferase, mitochondrial isoform X4
XM_039107860.2 → XP_038963788.1 phosphatidate cytidylyltransferase, mitochondrial isoform X3

Conserved Domains (1) summary

pfam09139
Location:13 → 188

Mmp37; Mitochondrial matrix Mmp37