Nnmt nicotinamide N-methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nnmtprovided by RGD
Official Full Name: nicotinamide N-methyltransferaseprovided by RGD
Primary source: RGD:1309606
See related: EnsemblRapid:ENSRNOG00000005930 AllianceGenome:RGD:1309606
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable nicotinamide N-methyltransferase activity. Involved in animal organ regeneration and response to xenobiotic stimulus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm. Orthologous to human NNMT (nicotinamide N-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 45.2), Adrenal (RPKM 26.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (57820156..57851301, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (48928663..48947734, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (52918437..52938172, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Progression of pulmonary hypertension is associated with the activation of the NNMT-1-methylnicotinamide pathway.
Title: Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension.
The downregulation of NNMT by PEITC is a novel finding that may represent an important mechanism for the cancer preventive effects of dietary PEITC.
Title: Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

BF406313 (e-PCR)
- UniSTS:248333

AU049445 (e-PCR)
- UniSTS:145892

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nicotinamide N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinamide N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables selenol Se-methyltransferase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within methylation	ISO Inferred from Sequence Orthology more info
involved_in nicotinamide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: nicotinamide N-methyltransferase

NP_001100289.1

EC 2.1.1.1

XP_038936990.1

EC 2.1.1.1

XP_038936991.1

EC 2.1.1.1

XP_038936993.1

EC 2.1.1.1

XP_038936994.1

EC 2.1.1.1

XP_038936995.1

EC 2.1.1.1

XP_063121183.1

EC 2.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106819.1 → NP_001100289.1 nicotinamide N-methyltransferase

See identical proteins and their annotated locations for NP_001100289.1

Status: PROVISIONAL

Source sequence(s)

CH473975

UniProtKB/TrEMBL

A6J4A4, D4A605

Conserved Domains (1) summary

pfam01234
Location:2 → 259

NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

57820156..57851301 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081062.2 → XP_038936990.1 nicotinamide N-methyltransferase isoform X2

Related

ENSRNOP00000086644.2, ENSRNOT00000117251.2

Conserved Domains (1) summary

pfam01234
Location:2 → 236

NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family
XM_063265113.1 → XP_063121183.1 nicotinamide N-methyltransferase isoform X1

UniProtKB/TrEMBL

A6J4A4, D4A605
XM_039081065.2 → XP_038936993.1 nicotinamide N-methyltransferase isoform X4

Conserved Domains (1) summary

cl17173
Location:18 → 164

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039081066.2 → XP_038936994.1 nicotinamide N-methyltransferase isoform X4

Conserved Domains (1) summary

cl17173
Location:18 → 164

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039081067.2 → XP_038936995.1 nicotinamide N-methyltransferase isoform X5

Conserved Domains (1) summary

cl17173
Location:2 → 121

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039081063.2 → XP_038936991.1 nicotinamide N-methyltransferase isoform X3

Conserved Domains (1) summary

cl17173
Location:2 → 136

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...