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    Zmpste24 zinc metallopeptidase STE24 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313564, updated on 28-Oct-2024

    Summary

    Official Symbol
    Zmpste24provided by RGD
    Official Full Name
    zinc metallopeptidase STE24provided by RGD
    Primary source
    RGD:1305570
    See related
    EnsemblRapid:ENSRNOG00000012054 AllianceGenome:RGD:1305570
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable double-stranded DNA binding activity and metalloendopeptidase activity. Predicted to be involved in CAAX-box protein processing. Predicted to act upstream of or within several processes, including heart development; regulation of gene expression; and regulation of intracellular signal transduction. Predicted to be located in membrane and nuclear envelope. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Kidney (RPKM 300.5), Adrenal (RPKM 237.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zmpste24 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (139912395..139945532, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (134627218..134660360, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (139982404..140015541, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10A like 3 Neighboring gene collagen type IX alpha 2 chain Neighboring gene uncharacterized LOC108351024 Neighboring gene transmembrane and coiled-coil domains 2 Neighboring gene uncharacterized LOC134486986

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in CAAX-box protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within CAMKK-AMPK signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion import into sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac ventricle development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epidermis development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epigenetic regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within growth plate cartilage development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hair follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inflammatory cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within kidney morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within maintenance of rDNA ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nuclear envelope organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear envelope organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nucleus organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression via chromosomal CpG island demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within prenylated protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of blood circulation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of mitotic cell cycle DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of stress-activated protein kinase signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of termination of RNA polymerase I transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within thymus development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ventricular cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CAAX prenyl protease 1 homolog
    Names
    zinc metallopeptidase, STE24 homolog
    zinc metalloproteinase, STE24 homolog
    NP_001101444.1
    XP_017448887.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107974.1NP_001101444.1  CAAX prenyl protease 1 homolog

      See identical proteins and their annotated locations for NP_001101444.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6IS04, D4A5K6
      Related
      ENSRNOP00000016410.4, ENSRNOT00000016410.7
      Conserved Domains (1) summary
      cd07343
      Location:22471
      M48A_Zmpste24p_like; Peptidase M48 subfamily A, a type 1 CaaX endopeptidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      139912395..139945532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593398.3XP_017448887.1  CAAX prenyl protease 1 homolog isoform X1