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    Ncoa7 nuclear receptor coactivator 7 [ Mus musculus (house mouse) ]

    Gene ID: 211329, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ncoa7provided by MGI
    Official Full Name
    nuclear receptor coactivator 7provided by MGI
    Primary source
    MGI:MGI:2444847
    See related
    Ensembl:ENSMUSG00000039697 AllianceGenome:MGI:2444847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030406N13Rik
    Summary
    Predicted to enable nuclear receptor binding activity and nuclear receptor coactivator activity. Acts upstream of or within negative regulation of cellular response to oxidative stress and negative regulation of peptidyl-cysteine S-nitrosylation. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human NCOA7 (nuclear receptor coactivator 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 9.0), cortex adult (RPKM 6.3) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ncoa7 in Genome Data Viewer
    Location:
    10 A4; 10 17.11 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (30521578..30683401, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (30645582..30807700, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:30320514-30320623 Neighboring gene STARR-positive B cell enhancer ABC_E6828 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:30338273-30338456 Neighboring gene predicted gene, 20300 Neighboring gene STARR-seq mESC enhancer starr_26197 Neighboring gene histidine triad nucleotide binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_26199 Neighboring gene STARR-seq mESC enhancer starr_26200 Neighboring gene STARR-positive B cell enhancer ABC_E5123 Neighboring gene STARR-seq mESC enhancer starr_26202 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8861 Neighboring gene STARR-seq mESC enhancer starr_26204 Neighboring gene nuclear encoded tRNA glutamic acid 9 (anticodon CTC) Neighboring gene predicted gene, 30618

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NCOA7 Regulates Growth and Metastasis of Clear Cell Renal Cell Carcinoma via MAPK/ERK Signaling Pathway. Guo J, et al. Int J Mol Sci, 2023 Jul 18. PMID 37511343, Free PMC Article
    2. Interaction of Estrogen Receptor Associated Protein (ERAP) 140 with ER beta decreases but its expression increases in aging mouse cerebral cortex. Paramanik V, et al. Cell Mol Neurobiol, 2010 Aug. PMID 20446107
    3. Targeted deletion of the Ncoa7 gene results in incomplete distal renal tubular acidosis in mice. Merkulova M, et al. Am J Physiol Renal Physiol, 2018 Jul 1. PMID 29384414, Free PMC Article
    4. Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells. Gargaro M, et al. Front Immunol, 2019. PMID 31481962, Free PMC Article
    5. Molecular characterization and bioinformatics analysis of Ncoa7B, a novel ovulation-associated and reproduction system-specific Ncoa7 isoform. Shkolnik K, et al. Reproduction, 2008 Mar. PMID 18299425

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NCOA7 Regulates Growth and Metastasis of Clear Cell Renal Cell Carcinoma via MAPK/ERK Signaling Pathway.
      Title: NCOA7 Regulates Growth and Metastasis of Clear Cell Renal Cell Carcinoma via MAPK/ERK Signaling Pathway.
    2. The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour.
      Title: The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour.
    3. Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells.
      Title: Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells.
    4. Ncoa7 is involved in collecting duct intercalated cells function and urine acidification in mice in vivo, likely through modulating the abundance of V-ATPase and other key acid-base regulators in the renal medulla.
      Title: Targeted deletion of the Ncoa7 gene results in incomplete distal renal tubular acidosis in mice.
    5. ERAP 140 interacts with ER beta and its interaction decreases but its expression increases with age in mouse cerebral cortex.
      Title: Interaction of Estrogen Receptor Associated Protein (ERAP) 140 with ER beta decreases but its expression increases in aging mouse cerebral cortex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of peptidyl-cysteine S-nitrosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor coactivator 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111267.2 → NP_001104737.1  nuclear receptor coactivator 7 isoform 2

      See identical proteins and their annotated locations for NP_001104737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 5' coding region and 5' UTR, and lacks much of the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct and shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      BC080742, EF602028
      Consensus CDS
      CCDS48530.1
      UniProtKB/TrEMBL
      A9Q6S9
      Related
      ENSMUSP00000150981.2, ENSMUST00000216172.2
      Conserved Domains (1) summary
      smart00584
      Location:59 → 221
      TLDc; domain in TBC and LysM domain containing proteins

    2. NM_001358841.1 → NP_001345770.1  nuclear receptor coactivator 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125532, BB870337, BC076623, BC080742, CV556753
      Consensus CDS
      CCDS87979.1
      UniProtKB/TrEMBL
      B9EIW5
      Related
      ENSMUSP00000149957.2, ENSMUST00000213836.2
      Conserved Domains (2) summary
      smart00584
      Location:770 → 932
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:119 → 161
      LysM; LysM domain

    3. NM_001358842.1 → NP_001345771.1  nuclear receptor coactivator 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC125532, BB870337, BC076623, BC080742
      Consensus CDS
      CCDS87978.1
      UniProtKB/TrEMBL
      A0A1L1SSS4
      Related
      ENSMUSP00000150021.2, ENSMUST00000215926.2
      Conserved Domains (2) summary
      smart00584
      Location:732 → 894
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:119 → 156
      LysM; LysM domain

    4. NM_172495.6 → NP_766083.3  nuclear receptor coactivator 7 isoform 1

      See identical proteins and their annotated locations for NP_766083.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AC125532, BB870337, BC076623, BC080742
      Consensus CDS
      CCDS23765.1
      UniProtKB/Swiss-Prot
      Q3TAR1, Q3UNB3, Q66K05, Q6DFV7, Q6ZQM4, Q8BJ15, Q8BJ39
      Related
      ENSMUSP00000066741.5, ENSMUST00000068567.5
      Conserved Domains (3) summary
      smart00584
      Location:781 → 943
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:91 → 161
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:119 → 161
      LysM; LysM domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      30521578..30683401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243155.4 → XP_011241457.1  nuclear receptor coactivator 7 isoform X3

      Conserved Domains (2) summary
      smart00584
      Location:791 → 883
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:119 → 161
      LysM; LysM domain

    2. XM_011243153.4 → XP_011241455.1  nuclear receptor coactivator 7 isoform X1

      Conserved Domains (2) summary
      smart00584
      Location:791 → 953
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:119 → 161
      LysM; LysM domain

    3. XM_011243154.4 → XP_011241456.1  nuclear receptor coactivator 7 isoform X2

      Conserved Domains (2) summary
      smart00584
      Location:780 → 942
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:119 → 161
      LysM; LysM domain

    4. XM_036155720.1 → XP_036011613.1  nuclear receptor coactivator 7 isoform X4

      Conserved Domains (2) summary
      smart00584
      Location:781 → 873
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:119 → 161
      LysM; LysM domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DFV7.2 GenPept UniProtKB/Swiss-Prot:Q6DFV7

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