Lepr leptin receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Leprprovided by RGD
Official Full Name: leptin receptorprovided by RGD
Primary source: RGD:3001
See related: EnsemblRapid:ENSRNOG00000023664 AllianceGenome:RGD:3001
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fa
Summary: Enables peptide hormone binding activity and protein-hormone receptor activity. Involved in several processes, including gonad development; negative regulation of behavior; and positive regulation of cell communication. Located in extracellular space. Used to study several diseases, including chronic kidney disease; congestive heart failure (multiple); glucose metabolism disease (multiple); obesity; and renal fibrosis. Biomarker of pre-eclampsia and short bowel syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 91.8), Liver (RPKM 83.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (121409735..121593201)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (116294409..116477904)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (120503475..120682281)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leptin receptor gene deficiency minimally affects osseointegration in rats.
Title: Leptin receptor gene deficiency minimally affects osseointegration in rats.
The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility.
Title: The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility.
TNF-alpha Antagonizes the Effect of Leptin on Insulin Secretion through FOXO1-Dependent Transcriptional Suppression of LepRb in INS-1 Cells.
Title: TNF-α Antagonizes the Effect of Leptin on Insulin Secretion through FOXO1-Dependent Transcriptional Suppression of LepRb in INS-1 Cells.
activation of the leptin receptor obR is an important pathogenic mechanism of ulcerative colitis, and leptin receptor deficiency may provide resistance against TNBSinduced colitis by inhibiting the NFkappaB and RhoA signaling pathways.
Title: Elevated expression of the leptin receptor ob‑R may contribute to inflammation in patients with ulcerative colitis.
LepR expression is required for the full anorexic effect of amylin; however, the neuronal activation in the area postrema seems to depend on the type of LepR mutation.
Title: Rodent models of leptin receptor deficiency are less sensitive to amylin.
this study shows that leptin receptor is expressed by tissue mast cells
Title: Leptin receptor is expressed by tissue mast cells.
The aim of this study was to investigate the expression and the molecular and functional relationships between leptin, orexin/hypocretin and ghrelin receptors.
Title: Orexin A/Hypocretin Modulates Leptin Receptor-Mediated Signaling by Allosteric Modulations Mediated by the Ghrelin GHS-R1A Receptor in Hypothalamic Neurons.
Leptin receptor was detected sciatic nerve
Title: The leptin receptor mutation of the obese Zucker rat causes sciatic nerve demyelination with a centripetal pattern defect.
These results suggest that leptin and its receptor may serve significant roles in the pathogenesis of varicocele-induced testicular dysfunction.
Title: Role of leptin and the leptin receptor in the pathogenesis of varicocele-induced testicular dysfunction.
high gonadal and gonadal-white adipose tissue expression of leptin system was observed in the offspring of dams fed a high fat diet during pregnancy and lactation.
Title: Maternal High-Fat Diet During Pregnancy and Lactation has Opposite Effects on Gonadal Expression of Leptin and Leptin Receptor in Rat Dams and Their Offspring.

Submit: New GeneRIF Correction See all GeneRIFs (88)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lepr (e-PCR), detects polymorphism
- UniSTS:265233

AU048762 (e-PCR)
- UniSTS:145212

D5Wox37 (e-PCR)
- UniSTS:239941

D5Wox38 (e-PCR)
- UniSTS:239942

D5Wox39 (e-PCR)
- UniSTS:239943

D5Rhw23 (e-PCR)
- UniSTS:519042

RH129126 (e-PCR)
- UniSTS:212434

RH94807 (e-PCR)
- UniSTS:120053

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables leptin receptor activity	IEA Inferred from Electronic Annotation more info
enables leptin receptor activity	ISO Inferred from Sequence Orthology more info
enables leptin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-hormone receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone growth	IEA Inferred from Electronic Annotation more info
involved_in bone growth	ISO Inferred from Sequence Orthology more info
involved_in bone growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to acetate	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to butyrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	IEA Inferred from Electronic Annotation more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in generation of precursor metabolites and energy	NAS Non-traceable Author Statement more info	PubMed
involved_in glial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycogen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in leptin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in leptin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in leptin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of hydrolase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovulation from ovarian follicle	IEP Inferred from Expression Pattern more info	PubMed
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone remodeling	IEA Inferred from Electronic Annotation more info
involved_in regulation of bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of feeding behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of transport	ISO Inferred from Sequence Orthology more info
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to leptin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to leptin	ISO Inferred from Sequence Orthology more info
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in sexual reproduction	IEA Inferred from Electronic Annotation more info
involved_in sexual reproduction	ISO Inferred from Sequence Orthology more info
involved_in sexual reproduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leptin receptor

Names: LEP-R; Leptin receptor (fatty); OB receptor; OB-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429454.1 → NP_001416383.1 leptin receptor isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZQD9
NM_001429459.1 → NP_001416388.1 leptin receptor isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

F1M9F2
NM_001429460.1 → NP_001416389.1 leptin receptor isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

F1M9F2
NM_001429461.1 → NP_001416390.1 leptin receptor isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I6AJP1
NM_001429462.1 → NP_001416391.1 leptin receptor isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I6AJP1
NM_012596.3 → NP_036728.2 leptin receptor isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZQD9, A6JRP2

Related

ENSRNOP00000080721.1, ENSRNOT00000044131.9

Conserved Domains (4) summary

smart00060
Location:738 → 818

FN3; Fibronectin type 3 domain

cd00063
Location:236 → 328

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:327 → 418

Lep_receptor_Ig; Ig-like C2-type domain

pfam18589
Location:429 → 531

ObR_Ig; Obesity receptor immunoglobulin like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

121409735..121593201

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109265.2 → XP_038965193.1 leptin receptor isoform X1

UniProtKB/TrEMBL

A0A8I5ZQD9, A6JRP2

Conserved Domains (4) summary

smart00060
Location:738 → 818

FN3; Fibronectin type 3 domain

cd00063
Location:236 → 328

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:327 → 418

Lep_receptor_Ig; Ig-like C2-type domain

pfam18589
Location:429 → 531

ObR_Ig; Obesity receptor immunoglobulin like domain
XM_039109264.2 → XP_038965192.1 leptin receptor isoform X1

Conserved Domains (4) summary

smart00060
Location:738 → 818

FN3; Fibronectin type 3 domain

cd00063
Location:236 → 328

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:327 → 418

Lep_receptor_Ig; Ig-like C2-type domain

pfam18589
Location:429 → 531

ObR_Ig; Obesity receptor immunoglobulin like domain
XM_039109267.2 → XP_038965195.1 leptin receptor isoform X3

Related

ENSRNOP00000093122.1, ENSRNOT00000093574.3

Conserved Domains (4) summary

smart00060
Location:738 → 818

FN3; Fibronectin type 3 domain

cd00063
Location:236 → 328

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:327 → 418

Lep_receptor_Ig; Ig-like C2-type domain

pfam18589
Location:429 → 531

ObR_Ig; Obesity receptor immunoglobulin like domain
XM_063287158.1 → XP_063143228.1 leptin receptor isoform X3
XM_063287157.1 → XP_063143227.1 leptin receptor isoform X2
XM_039109266.2 → XP_038965194.1 leptin receptor isoform X2

Related

ENSRNOP00000045398.5, ENSRNOT00000050597.7

Conserved Domains (4) summary

smart00060
Location:738 → 818

FN3; Fibronectin type 3 domain

cd00063
Location:236 → 328

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:327 → 418

Lep_receptor_Ig; Ig-like C2-type domain

pfam18589
Location:429 → 531

ObR_Ig; Obesity receptor immunoglobulin like domain