WNT10A Wnt family member 10A [Homo sapiens (human)] - Gene

Summary

Official Symbol: WNT10Aprovided by HGNC
Official Full Name: Wnt family member 10Aprovided by HGNC
Primary source: HGNC:HGNC:13829
See related: Ensembl:ENSG00000135925 MIM:606268; AllianceGenome:HGNC:13829
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OODD; SSPS; ECTD16; STHAG4
Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]
Expression: Broad expression in skin (RPKM 3.0), placenta (RPKM 1.8) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q35

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (218874116..218893928)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (219362519..219382296)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (219745574..219758650)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression.
Title: SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression.
Compound heterozygous WNT10A missense variations exacerbated the tooth agenesis caused by hypohidrotic ectodermal dysplasia.
Title: Compound heterozygous WNT10A missense variations exacerbated the tooth agenesis caused by hypohidrotic ectodermal dysplasia.
Short anagen hair syndrome: association with mono- and biallelic variants in WNT10A and a genetic overlap with male pattern hair loss.
Title: Short anagen hair syndrome: association with mono- and biallelic variants in WNT10A and a genetic overlap with male pattern hair loss.
The investigation of WNT6 and WNT10A single nucleotide polymorphisms as potential biomarkers for dental pulp calcification in orthodontic patients.
Title: The investigation of WNT6 and WNT10A single nucleotide polymorphisms as potential biomarkers for dental pulp calcification in orthodontic patients.
Phenotypic characteristics of taurodontism and a novel WNT10A variant in non-syndromic oligodontia family.
Title: Phenotypic characteristics of taurodontism and a novel WNT10A variant in non-syndromic oligodontia family.
Novel Dental Anomaly-associated Mutations in WNT10A Protein Binding Sites.
Title: Novel Dental Anomaly-associated Mutations in WNT10A Protein Binding Sites.
WNT10A variants: following the pattern of inheritance in tooth agenesis and self-reported family history of cancer.
Title: WNT10A variants: following the pattern of inheritance in tooth agenesis and self-reported family history of cancer.
Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer.
Title: Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer.
WNT10A induces apoptosis of senescent synovial resident stem cells through Wnt/calcium pathway-mediated HDAC5 phosphorylation in OA joints.
Title: WNT10A induces apoptosis of senescent synovial resident stem cells through Wnt/calcium pathway-mediated HDAC5 phosphorylation in OA joints.
Functional Effects of WNT10A Rare Variants Associated with Tooth Agenesis.
Title: Functional Effects of WNT10A Rare Variants Associated with Tooth Agenesis.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Odonto-onycho-dermal dysplasia MedGen: C0796093 OMIM: 257980 GeneReviews: Not available	not available
SchC6pf-Schulz-Passarge syndrome MedGen: C1857069 OMIM: 224750 GeneReviews: Not available	not available
Tooth agenesis, selective, 4 MedGen: C1835492 OMIM: 150400 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Common variants in the trichohyalin gene are associated with straight hair in Europeans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Web-based, participant-driven studies yield novel genetic associations for common traits. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in epidermis morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair follicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
involved_in sebaceous gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skin development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tongue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-10a

Names: wingless-type MMTV integration site family, member 10A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012179.1 RefSeqGene

Range

5320..18396

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_025216.3 → NP_079492.2 protein Wnt-10a precursor

See identical proteins and their annotated locations for NP_079492.2

Status: REVIEWED

Source sequence(s)

AC073128

Consensus CDS

CCDS2426.1

UniProtKB/Swiss-Prot

Q53S44, Q96TA7, Q9GZT5, Q9H7S8

UniProtKB/TrEMBL

A0A2H4GYZ1, A0A2K8FR47

Related

ENSP00000258411.3, ENST00000258411.8

Conserved Domains (1) summary

cl38924
Location:58 → 417

Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

218874116..218893928

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011511929.3 → XP_011510231.1 protein Wnt-10a isoform X1

UniProtKB/TrEMBL

A0A2H4GYZ1

Conserved Domains (1) summary

pfam00110
Location:35 → 385

wnt; wnt family
XM_011511930.2 → XP_011510232.1 protein Wnt-10a isoform X2

Conserved Domains (1) summary

cl19568
Location:67 → 127

wnt; wnt family