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    CDC23 cell division cycle 23 [ Homo sapiens (human) ]

    Gene ID: 8697, updated on 2-Nov-2024

    Summary

    Official Symbol
    CDC23provided by HGNC
    Official Full Name
    cell division cycle 23provided by HGNC
    Primary source
    HGNC:HGNC:1724
    See related
    Ensembl:ENSG00000094880 MIM:603462; AllianceGenome:HGNC:1724
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APC8; CUT23; ANAPC8
    Summary
    The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 12.7), testis (RPKM 9.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CDC23 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (138187650..138213323, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (138713942..138739579, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137523339..137549012, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 888, pseudogene Neighboring gene MPRA-validated peak5489 silencer Neighboring gene NME/NM23 family member 5 Neighboring gene bromodomain containing 8 Neighboring gene Sharpr-MPRA regulatory region 11877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23195 Neighboring gene kinesin family member 20A Neighboring gene Sharpr-MPRA regulatory region 7870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137581186-137581778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23196 Neighboring gene MPRA-validated peak5491 silencer Neighboring gene MPRA-validated peak5492 silencer Neighboring gene GDNF family receptor alpha 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16388 Neighboring gene RPS27A pseudogene 18 Neighboring gene cell division cycle 25C Neighboring gene ReSE screen-validated silencer GRCh37_chr5:137642973-137643148 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:137666651-137667604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16389 Neighboring gene uncharacterized LOC100128966

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in metaphase/anaphase transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic metaphase chromosome alignment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein branched polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of exit from mitosis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of meiotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of anaphase-promoting complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    cell division cycle protein 23 homolog
    Names
    anaphase-promoting complex subunit 8
    cell division cycle 23 homolog
    cyclosome subunit 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004661.4NP_004652.2  cell division cycle protein 23 homolog

      See identical proteins and their annotated locations for NP_004652.2

      Status: REVIEWED

      Source sequence(s)
      AC106752, BC017713
      Consensus CDS
      CCDS4200.2
      UniProtKB/Swiss-Prot
      A8K6E5, B4E3A2, B7WP05, D3DQB7, O75433, Q53FN2, Q9BS73, Q9UJX2
      Related
      ENSP00000378350.2, ENST00000394886.7
      Conserved Domains (3) summary
      COG2956
      Location:214491
      YciM; Lipopolysaccharide biosynthesis regulator YciM, contains six TPR domains and a predicted metal-binding C-terminal domain [Cell wall/membrane/envelope biogenesis]
      sd00006
      Location:367393
      TPR; TPR repeat [structural motif]
      pfam04049
      Location:45148
      ANAPC8; Anaphase promoting complex subunit 8 / Cdc23

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      138187650..138213323 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      138713942..138739579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)