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    MSR1 macrophage scavenger receptor 1 [ Homo sapiens (human) ]

    Gene ID: 4481, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MSR1provided by HGNC
    Official Full Name
    macrophage scavenger receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:7376
    See related
    Ensembl:ENSG00000038945 MIM:153622; AllianceGenome:HGNC:7376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SRA; SR-A; CD204; SR-AI; phSR1; phSR2; SCARA1; SR-AII; SR-AIII
    Summary
    This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lung (RPKM 26.5), gall bladder (RPKM 9.7) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MSR1 in Genome Data Viewer
    Location:
    8p22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (16107881..16192651, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (16374329..16459913, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (15965390..16050160, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene tumor suppressor candidate 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:15714775-15714991 Neighboring gene MPRA-validated peak6918 silencer Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1A pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:15851888-15852590 Neighboring gene ribosomal protein L32 pseudogene 19 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:16060074-16060578 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:16141012-16141954 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:16141955-16142895 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:16152188-16152760 Neighboring gene uncharacterized LOC101929028 Neighboring gene chaperonin containing TCP1 subunit 3 pseudogene 1 Neighboring gene mitochondrial ribosomal protein L49 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Interferon-α priming promotes lipid uptake and macrophage-derived foam cell formation: a novel link between interferon-α and atherosclerosis in lupus. Li J, et al. Arthritis Rheum, 2011 Feb. PMID 21280004
    2. Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA. Limmon GV, et al. FASEB J, 2008 Jan. PMID 17709607
    3. MSR1 variants and the risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China. Hsing AW, et al. Carcinogenesis, 2007 Dec. PMID 17768178
    4. Association between genetic polymorphisms of macrophage scavenger receptor 1 gene and risk of prostate cancer in the health professionals follow-up study. Chen YC, et al. Cancer Epidemiol Biomarkers Prev, 2008 Apr. PMID 18398045
    5. Conserved domains of the class A scavenger receptors: evolution and function. Bowdish DM, et al. Immunol Rev, 2009 Jan. PMID 19120472

    See all (145) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Detailed role of SR-A1 and SR-E3 in tumor biology, progression, and therapy.
      Title: Detailed role of SR-A1 and SR-E3 in tumor biology, progression, and therapy.
    2. Role of macrophage scavenger receptor 1 in the progression of dyslipidemia in acne vulgaris patients.
      Title: Role of macrophage scavenger receptor 1 in the progression of dyslipidemia in acne vulgaris patients.
    3. Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen.
      Title: Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen.
    4. Scavenger receptor a mediates glycated LDL transcytosis across endothelial cells to promote atherosclerosis.
      Title: Scavenger receptor a mediates glycated LDL transcytosis across endothelial cells to promote atherosclerosis.
    5. Comprehensive analysis of immune cell infiltration and role of MSR1 expression in aneurysmal subarachnoid haemorrhage.
      Title: Comprehensive analysis of immune cell infiltration and role of MSR1 expression in aneurysmal subarachnoid haemorrhage.
    6. Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis.
      Title: Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis.
    7. MSR1 characterized by chromatin accessibility mediates M2 macrophage polarization to promote gastric cancer progression.
      Title: MSR1 characterized by chromatin accessibility mediates M2 macrophage polarization to promote gastric cancer progression.
    8. Comprehensive analysis of the prognostic and role in immune cell infiltration of MSR1 expression in lower-grade gliomas.
      Title: Comprehensive analysis of the prognostic and role in immune cell infiltration of MSR1 expression in lower-grade gliomas.
    9. MSR1 and NEP Are Correlated with Alzheimer's Disease Amyloid Pathology and Apolipoprotein Alterations.
      Title: MSR1 and NEP Are Correlated with Alzheimer's Disease Amyloid Pathology and Apolipoprotein Alterations.
    10. Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis.
      Title: Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis.
    Submit: New GeneRIF Correction See all GeneRIFs (101)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Barrett esophagus
    MedGen: C0004763 OMIM: 614266 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amyloid-beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cargo receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables low-density lipoprotein particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low-density lipoprotein particle binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables scavenger receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amyloid-beta clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipoprotein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in plasma lipoprotein particle clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma lipoprotein particle clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of cholesterol storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cholesterol storage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of macrophage derived foam cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in receptor-mediated endocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    macrophage scavenger receptor types I and II
    Names
    macrophage acetylated LDL receptor I and II
    macrophage scavenger receptor type III
    scavenger receptor class A member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012102.1 RefSeqGene

      Range
      5141..89911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001363744.1 → NP_001350673.1  macrophage scavenger receptor types I and II isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC023396, AK293217, BC063878
      Consensus CDS
      CCDS87581.1
      UniProtKB/TrEMBL
      B4DDJ5
      Related
      ENSP00000405453.2, ENST00000445506.6
      Conserved Domains (4) summary
      pfam01391
      Location:298 → 352
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:368 → 468
      SR; Scavenger receptor Cys-rich
      pfam03523
      Location:139 → 187
      Macscav_rec; Macrophage scavenger receptor
      cl26252
      Location:122 → 287
      AAA_13; AAA domain

    2. NM_002445.4 → NP_002436.1  macrophage scavenger receptor types I and II isoform type 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (SR-AII), also known as phSR2, uses two alternative exons and also lacks two downstream exons compared to variant SR-AI. These differences causes an alternate 3' end in the coding region, and has a distinct 3' UTR. It encodes isoform type 2 that is shorter and has a different C-terminus than isoform type 1.
      Source sequence(s)
      AC023396, D90188
      Consensus CDS
      CCDS5997.1
      UniProtKB/Swiss-Prot
      P21757
      Related
      ENSP00000371428.4, ENST00000381998.8
      Conserved Domains (2) summary
      pfam01391
      Location:280 → 334
      Collagen; Collagen triple helix repeat (20 copies)
      pfam03523
      Location:121 → 169
      Macscav_rec; Macrophage scavenger receptor

    3. NM_138715.3 → NP_619729.1  macrophage scavenger receptor types I and II isoform type 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (SR-AI), also known as phSR1, encodes the longest isoform.
      Source sequence(s)
      AC023396, D90187, DA995755
      Consensus CDS
      CCDS5995.1
      UniProtKB/Swiss-Prot
      D3DSP3, O60505, P21757, P21759, Q45F10
      Related
      ENSP00000262101.5, ENST00000262101.10
      Conserved Domains (4) summary
      pfam01391
      Location:280 → 334
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:350 → 450
      SR; Scavenger receptor Cys-rich
      pfam03523
      Location:121 → 169
      Macscav_rec; Macrophage scavenger receptor
      cl26252
      Location:104 → 269
      AAA_13; AAA domain

    4. NM_138716.3 → NP_619730.1  macrophage scavenger receptor types I and II isoform type 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (SR-AIII) lacks an exon in the coding region, but maintains the same reading frame, as compared to variant SR-AI. It encodes an isoform type 3 that lacks 63 internal amino acids compared to isoform type 1.
      Source sequence(s)
      AC023396, D90187, DA995755
      Consensus CDS
      CCDS5996.1
      UniProtKB/Swiss-Prot
      P21757
      Related
      ENSP00000262100.3, ENST00000350896.3
      Conserved Domains (4) summary
      pfam01391
      Location:280 → 334
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:346 → 387
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:318 → 387
      SRCR; Scavenger receptor cysteine-rich domain
      pfam03523
      Location:121 → 169
      Macscav_rec; Macrophage scavenger receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      16107881..16192651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447161.2 → XP_024302929.1  macrophage scavenger receptor types I and II isoform X1

      Conserved Domains (3) summary
      pfam01391
      Location:298 → 352
      Collagen; Collagen triple helix repeat (20 copies)
      pfam03523
      Location:139 → 187
      Macscav_rec; Macrophage scavenger receptor
      cl26252
      Location:122 → 287
      AAA_13; AAA domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      16374329..16459913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360498.1 → XP_054216473.1  macrophage scavenger receptor types I and II isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21757.1 GenPept UniProtKB/Swiss-Prot:P21757

    Gene LinkOut

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