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    Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 26921, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Map4k4provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 4provided by MGI
    Primary source
    MGI:MGI:1349394
    See related
    Ensembl:ENSMUSG00000026074 AllianceGenome:MGI:1349394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HGK; Nik; 9430080K19Rik
    Summary
    Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell-substrate junction organization; positive regulation of intracellular signal transduction; and positive regulation of keratinocyte migration. Located in focal adhesion. Is expressed in several structures, including genitourinary system; molar; nervous system; neural retina; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E14 (RPKM 64.6), CNS E11.5 (RPKM 64.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Map4k4 in Genome Data Viewer
    Location:
    1 B; 1 18.53 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (39939806..40065470)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (39900902..40026310)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700066B17 gene Neighboring gene STARR-seq mESC enhancer starr_00730 Neighboring gene predicted gene, 35600 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39952403-39952658 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39953411-39953598 Neighboring gene STARR-seq mESC enhancer starr_00731 Neighboring gene STARR-seq mESC enhancer starr_00732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39991996-39992105 Neighboring gene STARR-positive B cell enhancer ABC_E9463 Neighboring gene VISTA enhancer mm1333 Neighboring gene STARR-positive B cell enhancer mm9_chr1:40142581-40142881 Neighboring gene predicted gene, 16894 Neighboring gene STARR-seq mESC enhancer starr_00736 Neighboring gene interleukin 1 receptor, type II Neighboring gene predicted gene, 35741

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons. Larhammar M, et al. J Neurosci, 2017 Nov 15. PMID 28993483, Free PMC Article
    2. MAP4K4 deletion inhibits proliferation and activation of CD4(+) T cell and promotes T regulatory cell generation in vitro. Huang H, et al. Cell Immunol, 2014 May-Jun. PMID 24681727
    3. Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia. Roth Flach RJ, et al. J Biol Chem, 2016 Jul 29. PMID 27226575, Free PMC Article
    4. Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity. Roth Flach RJ, et al. Am J Physiol Endocrinol Metab, 2017 Sep 1. PMID 28611026, Free PMC Article
    5. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Aouadi M, et al. Nature, 2009 Apr 30. PMID 19407801, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways.
      Title: Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways.
    2. MAP4K4 is involved in the neuronal development of retinal photoreceptors.
      Title: MAP4K4 is involved in the neuronal development of retinal photoreceptors.
    3. Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity.
      Title: Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity.
    4. These studies highlight a MAP4K4-initiated signaling cascade that induces motor neuron degeneration.
      Title: MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis.
    5. TLR4-MAP4K4 pathway can regulate retinal neovascularization.
      Title: Role of TLR4-MAP4K4 signaling pathway in models of oxygen-induced retinopathy.
    6. Study identified a novel splicing network composed of RBM4a, SRSF3, and MAP4K4 in brown adipogenesis and subsequently manipulating the effect of downstream JNK signaling which contributes to insulin resistance and reduced metabolism.
      Title: RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis.
    7. the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta/smad signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells.
      Title: FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway.
    8. Blood endothelial Map4k4 promotes vascular dysfunction and impairs glucose homeostasis in adult animals, lymphatic endothelial Map4k4 is required to maintain lymphatic vascular integrity and regulate immune cell trafficking in obesity.
      Title: Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity.
    9. Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate.
      Title: Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function.
    10. These results demonstrate that protein kinase Map4k4 drives obesity-induced hyperinsulinemia and insulin resistance in part by promoting insulin secretion from beta cells in mice.
      Title: Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (4) 
    • Gene trapped (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP kinase kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables creatine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron projection regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ARF protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of focal adhesion disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of keratinocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 4
    Names
    HPK/GCK-like kinase HGK
    MAPK/ERK kinase kinase kinase 4
    MEK kinase kinase 4
    MEKKK 4
    NCK interacting kinase
    nck-interacting kinase
    NP_001239129.1
    NP_001239130.1
    NP_001239131.1
    NP_032722.2
    XP_006496104.1
    XP_006496105.1
    XP_006496106.1
    XP_006496108.1
    XP_006496109.1
    XP_011236832.1
    XP_017176483.1
    XP_017176487.1
    XP_017176490.1
    XP_017176491.1
    XP_017176493.1
    XP_017176499.1
    XP_017176500.1
    XP_017176502.1
    XP_017176507.1
    XP_017176510.1
    XP_030110570.1
    XP_030110580.1
    XP_036021388.1
    XP_036021391.1
    XP_036021394.1
    XP_036021398.1
    XP_036021400.1
    XP_036021407.1
    XP_036021415.1
    XP_036021418.1
    XP_036021421.1
    XP_036021424.1
    XP_036021426.1
    XP_036021430.1
    XP_036021432.1
    XP_036021435.1
    XP_036021436.1
    XP_036021440.1
    XP_036021441.1
    XP_036021442.1
    XP_036021443.1
    XP_036021445.1
    XP_036021446.1
    XP_036021449.1
    XP_036021450.1
    XP_036021454.1
    XP_036021456.1
    XP_036021458.1
    XP_036021460.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252200.1 → NP_001239129.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK159799, AV445090, BB651050, BC145390, BF721981, BQ571658, CJ142598, U88984
      Consensus CDS
      CCDS78573.1
      UniProtKB/TrEMBL
      A0A0A6YW53, B7ZNR8
      Related
      ENSMUSP00000141400.2, ENSMUST00000195860.6
      Conserved Domains (3) summary
      smart00036
      Location:970 → 1268
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001252201.1 → NP_001239130.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 3

      See identical proteins and their annotated locations for NP_001239130.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the presence and absence of in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AK159799, AV445090, BB651050, BC141109, BC145390, BF721981, BQ571658, CJ142598, U88984
      Consensus CDS
      CCDS78576.1
      UniProtKB/Swiss-Prot
      P97820
      UniProtKB/TrEMBL
      B2RUE8
      Related
      ENSMUSP00000141862.2, ENSMUST00000193682.6
      Conserved Domains (3) summary
      smart00036
      Location:903 → 1201
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001252202.1 → NP_001239131.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 4

      See identical proteins and their annotated locations for NP_001239131.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks multiple in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (4), compared to isoform 1.
      Source sequence(s)
      AK159799, AV445090, BB651050, BC145390, BC145391, BF721981, BQ571658, CJ142598, U88984
      Consensus CDS
      CCDS78575.1
      UniProtKB/TrEMBL
      B7ZNR9, F8VPL5
      Related
      ENSMUSP00000142056.2, ENSMUST00000195259.6
      Conserved Domains (3) summary
      smart00036
      Location:890 → 1188
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    4. NM_008696.2 → NP_032722.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform 2

      See identical proteins and their annotated locations for NP_032722.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AC132909, AC166238, AK138966, CF531764, U88984
      Consensus CDS
      CCDS35546.1
      UniProtKB/Swiss-Prot
      P97820
      UniProtKB/TrEMBL
      A0A0A6YWR8
      Related
      ENSMUSP00000141665.2, ENSMUST00000192509.6
      Conserved Domains (3) summary
      smart00036
      Location:916 → 1214
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      39939806..40065470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496041.3 → XP_006496104.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1

      UniProtKB/TrEMBL
      B7ZNR8
      Conserved Domains (2) summary
      smart00036
      Location:1065 → 1363
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    2. XM_011238530.3 → XP_011236832.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X15

      UniProtKB/TrEMBL
      B7ZNR8
      Conserved Domains (2) summary
      smart00036
      Location:1001 → 1299
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    3. XM_017321001.3 → XP_017176490.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X4

      UniProtKB/TrEMBL
      E9PVG7
      Conserved Domains (2) summary
      smart00036
      Location:1062 → 1360
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    4. XM_017321010.3 → XP_017176499.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X16

      UniProtKB/TrEMBL
      E9PVG7
      Conserved Domains (2) summary
      smart00036
      Location:998 → 1296
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    5. XM_017320994.3 → XP_017176483.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X2

      UniProtKB/TrEMBL
      B7ZNR8
      Conserved Domains (2) summary
      smart00036
      Location:1064 → 1362
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    6. XM_017320998.3 → XP_017176487.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X3

      UniProtKB/TrEMBL
      B7ZNR8
      Conserved Domains (2) summary
      smart00036
      Location:1063 → 1361
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    7. XM_036165495.1 → XP_036021388.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X5

      UniProtKB/TrEMBL
      B7ZNR8
      Conserved Domains (2) summary
      smart00036
      Location:1062 → 1360
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    8. XM_017321011.3 → XP_017176500.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X17

      UniProtKB/TrEMBL
      F8VPL5
      Conserved Domains (2) summary
      smart00036
      Location:988 → 1286
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    9. XM_036165549.1 → XP_036021442.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X34

      UniProtKB/TrEMBL
      F8VPL5
      Conserved Domains (2) summary
      smart00036
      Location:924 → 1222
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    10. XM_036165525.1 → XP_036021418.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X19

      UniProtKB/TrEMBL
      F8VPL5
      Conserved Domains (2) summary
      smart00036
      Location:985 → 1283
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    11. XM_036165522.1 → XP_036021415.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X18

      UniProtKB/TrEMBL
      F8VPL5
      Conserved Domains (2) summary
      smart00036
      Location:987 → 1285
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    12. XM_006496042.3 → XP_006496105.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X11

      UniProtKB/TrEMBL
      Q6ZQ68
      Conserved Domains (2) summary
      smart00036
      Location:1011 → 1309
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    13. XM_036165537.1 → XP_036021430.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X26

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:947 → 1245
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    14. XM_030254710.2 → XP_030110570.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X12

      UniProtKB/TrEMBL
      Q6ZQ68
      Conserved Domains (2) summary
      smart00036
      Location:1010 → 1308
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    15. XM_036165539.1 → XP_036021432.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X27

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:946 → 1244
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    16. XM_017321004.3 → XP_017176493.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X13

      UniProtKB/TrEMBL
      Q6ZQ68
      Conserved Domains (2) summary
      smart00036
      Location:1009 → 1307
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    17. XM_036165542.1 → XP_036021435.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X28

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:945 → 1243
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    18. XM_036165514.1 → XP_036021407.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X14

      UniProtKB/TrEMBL
      Q6ZQ68
      Conserved Domains (2) summary
      smart00036
      Location:1008 → 1306
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    19. XM_036165543.1 → XP_036021436.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X29

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:944 → 1242
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    20. XM_017321018.3 → XP_017176507.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X30

      UniProtKB/TrEMBL
      F8VPL5
      Conserved Domains (2) summary
      smart00036
      Location:934 → 1232
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    21. XM_036165557.1 → XP_036021450.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X40

      UniProtKB/TrEMBL
      F8VPL5
      Conserved Domains (2) summary
      smart00036
      Location:870 → 1168
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    22. XM_017321021.3 → XP_017176510.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X32

      UniProtKB/TrEMBL
      F8VPL5
      Conserved Domains (2) summary
      smart00036
      Location:931 → 1229
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    23. XM_036165563.1 → XP_036021456.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X42

      UniProtKB/TrEMBL
      F8VPL5
      Conserved Domains (2) summary
      smart00036
      Location:867 → 1165
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    24. XM_036165547.1 → XP_036021440.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X31

      UniProtKB/TrEMBL
      F8VPL5
      Conserved Domains (2) summary
      smart00036
      Location:933 → 1231
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    25. XM_036165561.1 → XP_036021454.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X41

      UniProtKB/TrEMBL
      F8VPL5
      Conserved Domains (2) summary
      smart00036
      Location:869 → 1167
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    26. XM_036165548.1 → XP_036021441.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X33

      UniProtKB/TrEMBL
      F8VPL5
      Conserved Domains (2) summary
      smart00036
      Location:930 → 1228
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    27. XM_017321002.3 → XP_017176491.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X6

      UniProtKB/TrEMBL
      B7ZNR8
      Conserved Domains (2) summary
      smart00036
      Location:1034 → 1332
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    28. XM_036165505.1 → XP_036021398.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X9

      UniProtKB/TrEMBL
      E9PVG7
      Conserved Domains (2) summary
      smart00036
      Location:1031 → 1329
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    29. XM_036165533.1 → XP_036021426.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X24

      UniProtKB/TrEMBL
      E9PVG7
      Related
      ENSMUSP00000126961.3, ENSMUST00000163854.9
      Conserved Domains (2) summary
      smart00036
      Location:967 → 1265
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    30. XM_036165498.1 → XP_036021391.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X7

      UniProtKB/TrEMBL
      B7ZNR8
      Conserved Domains (2) summary
      smart00036
      Location:1033 → 1331
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    31. XM_036165501.1 → XP_036021394.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X8

      UniProtKB/TrEMBL
      B7ZNR8
      Conserved Domains (2) summary
      smart00036
      Location:1032 → 1330
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    32. XM_036165507.1 → XP_036021400.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X10

      UniProtKB/TrEMBL
      E9PVG7
      Conserved Domains (2) summary
      smart00036
      Location:1029 → 1327
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    33. XM_006496045.3 → XP_006496108.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X39

      UniProtKB/TrEMBL
      F8VPL5
      Conserved Domains (2) summary
      smart00036
      Location:893 → 1191
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    34. XM_006496043.3 → XP_006496106.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X25

      UniProtKB/TrEMBL
      A0A0A6YWM8, F8VPL5
      Related
      ENSMUSP00000141613.2, ENSMUST00000195636.6
      Conserved Domains (2) summary
      smart00036
      Location:954 → 1252
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    35. XM_017321013.3 → XP_017176502.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X20

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:980 → 1278
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    36. XM_030254720.2 → XP_030110580.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X22

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:977 → 1275
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    37. XM_036165552.1 → XP_036021445.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X36

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:913 → 1211
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    38. XM_036165528.1 → XP_036021421.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X21

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:979 → 1277
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    39. XM_036165550.1 → XP_036021443.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X35

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:915 → 1213
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    40. XM_036165531.1 → XP_036021424.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X23

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:976 → 1274
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    41. XM_036165565.1 → XP_036021458.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X43

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:839 → 1137
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    42. XM_036165556.1 → XP_036021449.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X38

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:900 → 1198
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    43. XM_036165567.1 → XP_036021460.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X45

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:836 → 1134
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    44. XM_036165553.1 → XP_036021446.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X37

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:902 → 1200
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    45. XM_006496046.3 → XP_006496109.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X44

      UniProtKB/Swiss-Prot
      P97820
      Conserved Domains (2) summary
      smart00036
      Location:838 → 1136
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8 → 289
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_001784729.3 RNA Sequence

    2. XR_003955681.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97820.1 GenPept UniProtKB/Swiss-Prot:P97820

    Gene LinkOut

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