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    GPR18 G protein-coupled receptor 18 [ Homo sapiens (human) ]

    Gene ID: 2841, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPR18provided by HGNC
    Official Full Name
    G protein-coupled receptor 18provided by HGNC
    Primary source
    HGNC:HGNC:4472
    See related
    Ensembl:ENSG00000125245 MIM:602042; AllianceGenome:HGNC:4472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRV2
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway and positive regulation of Rho protein signal transduction. Predicted to act upstream of or within T cell differentiation; negative regulation of leukocyte chemotaxis; and negative regulation of tumor necrosis factor production. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lymph node (RPKM 11.0), testis (RPKM 4.7) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR18 in Genome Data Viewer
    Location:
    13q32.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (99254739..99258379, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (98464982..98489443, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99906993..99910633, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:99857838-99858338 Neighboring gene RN7SK pseudogene 9 Neighboring gene UBA domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7932 Neighboring gene H2A.Z histone pseudogene 3 Neighboring gene uncharacterized LOC124903198 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:99914553-99914775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:99955752-99956300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:99956301-99956847 Neighboring gene G protein-coupled receptor 183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain. Fabisiak A, et al. Neurogastroenterol Motil, 2021 Mar. PMID 33058313
    2. Towards A Molecular Understanding of The Cannabinoid Related Orphan Receptor GPR18: A Focus on Its Constitutive Activity. Sotudeh N, et al. Int J Mol Sci, 2019 May 9. PMID 31075933, Free PMC Article
    3. GPR18 expression on PMNs as biomarker for outcome in patient with sepsis. Zhang L, et al. Life Sci, 2019 Jan 15. PMID 30503722
    4. Lipoxin and Resolvin Receptors Transducing the Resolution of Inflammation in Cardiovascular Disease. Pirault J, et al. Front Pharmacol, 2018. PMID 30487747, Free PMC Article
    5. Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Flegel C, et al. Sci Rep, 2016 Aug 30. PMID 27572937, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice.
      Title: The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice.
    2. Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain.
      Title: Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain.
    3. molecular dynamics simulations of wild-type (WT) GPR18 and the A3.39N mutant in fully hydrated (POPC) phophatidylcholine lipid bilayers, are reported.
      Title: Towards A Molecular Understanding of The Cannabinoid Related Orphan Receptor GPR18: A Focus on Its Constitutive Activity.
    4. GPR18 interacts with cannabinoid CB2 but not with CB1 receptors.
      Title: Molecular and functional interaction between GPR18 and cannabinoid CB(2) G-protein-coupled receptors. Relevance in neurodegenerative diseases.
    5. Lipopolysaccharides-Toll-like receptor (TLR)4 signaling mediated the GPR18 expression on polymorphonuclear neutrophils. These results indicate that decreased percentage GPR18-positive polymorphonuclear neutrophils is associated with increased severity and poorer outcome of sepsis.
      Title: GPR18 expression on PMNs as biomarker for outcome in patient with sepsis.
    6. Results indicate that G protein-coupled receptor 18 (GPR18) might be involved in physiological processes of spermatozoa, suggesting GPR18 to be a potential player in sperm physiology.
      Title: Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18.
    7. A novel RvD2-GPR18 resolution axis stimulates human and mouse phagocyte functions to control bacterial infections and promote organ protection.
      Title: Identification of resolvin D2 receptor mediating resolution of infections and organ protection.
    8. the results presented herein provide further evidence for GPR18 as a candidate cannabinoid receptor
      Title: Activation of GPR18 by cannabinoid compounds: a tale of biased agonism.
    9. REVIEW: functional properties and in vivo biology
      Title: EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors.
    10. GPR18, the most abundantly overexpressed orphan G-protein-coupled receptor in all melanoma metastases, is constitutively active and inhibits apoptosis, indicating an important role for GPR18 in tumor cell survival.
      Title: Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CD8-positive, alpha-beta intraepithelial T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CD8-positive, gamma-delta intraepithelial T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of leukocyte chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    N-arachidonyl glycine receptor
    Names
    NAGly receptor
    resolvin D2 receptor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098200.2 → NP_001091670.1  N-arachidonyl glycine receptor

      See identical proteins and their annotated locations for NP_001091670.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA825595, BC008569
      Consensus CDS
      CCDS9491.1
      UniProtKB/Swiss-Prot
      Q14330, Q6GTM3, Q96HI6, Q9H2L2
      UniProtKB/TrEMBL
      H9NIM1
      Related
      ENSP00000380610.2, ENST00000397470.5
      Conserved Domains (1) summary
      cd15166
      Location:23 → 297
      7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_005292.4 → NP_005283.1  N-arachidonyl glycine receptor

      See identical proteins and their annotated locations for NP_005283.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL160155, BC050646, BI770379
      Consensus CDS
      CCDS9491.1
      UniProtKB/Swiss-Prot
      Q14330, Q6GTM3, Q96HI6, Q9H2L2
      UniProtKB/TrEMBL
      H9NIM1
      Related
      ENSP00000380613.2, ENST00000397473.7
      Conserved Domains (1) summary
      cd15166
      Location:23 → 297
      7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      99254739..99258379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      98464982..98489443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374477.1 → XP_054230452.1  N-arachidonyl glycine receptor isoform X1

      UniProtKB/Swiss-Prot
      Q14330, Q6GTM3, Q96HI6, Q9H2L2
      UniProtKB/TrEMBL
      H9NIM1

    2. XM_054374478.1 → XP_054230453.1  N-arachidonyl glycine receptor isoform X1

      UniProtKB/Swiss-Prot
      Q14330, Q6GTM3, Q96HI6, Q9H2L2
      UniProtKB/TrEMBL
      H9NIM1

    3. XM_054374479.1 → XP_054230454.1  N-arachidonyl glycine receptor isoform X1

      UniProtKB/Swiss-Prot
      Q14330, Q6GTM3, Q96HI6, Q9H2L2
      UniProtKB/TrEMBL
      H9NIM1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14330.2 GenPept UniProtKB/Swiss-Prot:Q14330

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