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    Gpa33 glycoprotein A33 transmembrane [ Mus musculus (house mouse) ]

    Gene ID: 59290, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gpa33provided by MGI
    Official Full Name
    glycoprotein A33 transmembraneprovided by MGI
    Primary source
    MGI:MGI:1891703
    See related
    Ensembl:ENSMUSG00000000544 AllianceGenome:MGI:1891703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mA33; 2010310L10Rik; 2210401D16Rik
    Summary
    Located in plasma membrane. Is expressed in several structures, including blastocyst; gut; sensory organ; skeleton; and urogenital sinus. Orthologous to human GPA33 (glycoprotein A33). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 349.7), large intestine adult (RPKM 252.6) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpa33 in Genome Data Viewer
    Location:
    1 H2.3; 1 73.49 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165957790..165994079)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (166130221..166166510)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm757 Neighboring gene predicted gene, 39693 Neighboring gene serine/threonine/tyrosine interacting like 2 Neighboring gene STARR-seq mESC enhancer starr_02920 Neighboring gene STARR-positive B cell enhancer ABC_E7772 Neighboring gene STARR-seq mESC enhancer starr_02926 Neighboring gene maelstrom spermatogenic transposon silencer Neighboring gene immunoglobulin-like domain containing receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A33 antigen-deficient mice have defective colonic mucosal repair. Pereira-Fantini PM, et al. Inflamm Bowel Dis, 2010 Apr. PMID 19856415
    2. Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease. Williams BB, et al. Dis Model Mech, 2015 Aug 1. PMID 26035389, Free PMC Article
    3. Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Orner GA, et al. Mutat Res, 2002 Sep 30. PMID 12351151
    4. The murine A33 antigen is expressed at two distinct sites during development, the ICM of the blastocyst and the intestinal epithelium. Abud HE, et al. Mech Dev, 2000 Nov. PMID 11044613
    5. Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells. Johnstone CN, et al. Am J Physiol Gastrointest Liver Physiol, 2000 Sep. PMID 10960348

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gpa33(-/-) mice provide a valuable model to study the mechanisms linking intestinal permeability and multiple inflammatory pathologies.
      Title: Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease.
    2. A33 antigen-deficient mice have defective colonic mucosal repair.
      Title: A33 antigen-deficient mice have defective colonic mucosal repair.
    3. cloning, chromosomal localizations, exon-intron structures and transcription start sites - target gene for the intestine-specific homeobox transcription factor, CDX1
      Title: Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Gene trapped (1) 
    • Targeted (9)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell surface A33 antigen
    Names
    A33 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360925.1 → NP_001347854.1  cell surface A33 antigen isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC034122, AC138358
      Conserved Domains (2) summary
      smart00408
      Location:46 → 110
      IGc2; Immunoglobulin C-2 Type
      pfam13908
      Location:123 → 154
      Shisa; Wnt and FGF inhibitory regulator

    2. NM_001360926.1 → NP_001347855.1  cell surface A33 antigen isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC138358, AK008784
      UniProtKB/TrEMBL
      Q9D7V7
      Related
      ENSMUST00000027847.7
      Conserved Domains (1) summary
      pfam07686
      Location:31 → 138
      V-set; Immunoglobulin V-set domain

    3. NM_021610.2 → NP_067623.1  cell surface A33 antigen isoform 1 precursor

      See identical proteins and their annotated locations for NP_067623.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC138358, AF247659
      Consensus CDS
      CCDS15447.1
      UniProtKB/Swiss-Prot
      Q922D5, Q9JKA5
      UniProtKB/TrEMBL
      A0A0R4J209
      Related
      ENSMUSP00000060147.8, ENSMUST00000060833.14
      Conserved Domains (4) summary
      smart00408
      Location:154 → 218
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:151 → 226
      IG_like; Immunoglobulin like
      pfam07686
      Location:31 → 138
      V-set; Immunoglobulin V-set domain
      pfam13908
      Location:240 → 262
      Shisa; Wnt and FGF inhibitory regulator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      165957790..165994079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JKA5.2 GenPept UniProtKB/Swiss-Prot:Q9JKA5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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