LOC111832671 albumin (ALB) 5' regulatory region [Homo sapiens (human)] - Gene

Summary

Gene symbol: LOC111832671
Gene description: albumin (ALB) 5' regulatory region
Gene type: biological region
Feature type(s): protein_bind
regulatory: TATA_box, enhancer, promoter
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This region represents the promoter and associated upstream enhancers of the albumin (ALB) gene, which is relevant for COVID-19 prognosis. Activity of this region is stimulated by binding by HNF1 homeobox A and CCAAT/enhancer-binding protein, and is negatively regulated by tumor protein p53. An enhancer in this region may also regulate activity of the alpha fetoprotein promoter located approximately 30 kb downstream. [provided by RefSeq, Jun 2021]
Annotation information: Note: This locus has been reviewed for its involvement in coronavirus biology, and is involved in host gene regulation.
Orthologs: mouse all
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Genomic context

Location:: 4q13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (73397685..73404342)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (76741387..76748044)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (74263402..74270059)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.