U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    BOLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 [ Bos taurus (cattle) ]

    Gene ID: 282535, updated on 6-Jun-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    BOLA-DQA2
    Gene description
    major histocompatibility complex, class II, DQ alpha 2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    BoLA-DQA; BoLA-DQA1
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See BOLA-DQA2 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (25583031..25589201, complement)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene glial cells missing transcription factor 1 Neighboring gene ELOVL fatty acid elongase 5 Neighboring gene major histocompatibility complex, class II, DQ beta Neighboring gene major histocompatibility complex, class II, DQ alpha 5

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of splice variants, targeted microRNAs and functional single nucleotide polymorphisms of the BOLA-DQA2 gene in dairy cattle. Hou Q, et al. DNA Cell Biol, 2012 May. PMID 22084936, Free PMC Article
    2. Nucleotide sequence and the molecular evolution of a new A2 gene in the DQ subregion of the bovine major histocompatibility complex. Morooka A, et al. Biochem Biophys Res Commun, 1995 Jul 6. PMID 7611993
    3. Characterization of cattle cDNA sequences from two DQA loci. Russell GC, et al. Immunogenetics, 1997. PMID 9089108
    4. Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray. Ishiwata H, et al. Mol Reprod Dev, 2003 May. PMID 12658628
    5. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single nucleotide polymorphisms in BOLA-DQA2 gene is associated with mastitis resistance.
      Title: Identification of splice variants, targeted microRNAs and functional single nucleotide polymorphisms of the BOLA-DQA2 gene in dairy cattle.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC128231

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    major histocompatibility complex, class II, DQ alpha 2
    Names
    MHC class II DQA
    MHC class II antigen

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012681.1 → NP_001012699.1  major histocompatibility complex, class II, DQ alpha 2 precursor

      See identical proteins and their annotated locations for NP_001012699.1

      Status: PROVISIONAL

      Source sequence(s)
      D50048
      UniProtKB/TrEMBL
      O19334, O19335
      Conserved Domains (2) summary
      cd05767
      Location:112 → 204
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:30 → 107
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      25583031..25589201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059880592.1 → XP_059736575.1  major histocompatibility complex, class II, DQ alpha 2

      UniProtKB/TrEMBL
      Q30308
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials